Inhibition of metastatic brain cancer in Sonic Hedgehog medulloblastoma using caged nitric oxide albumin nanoparticles
Title
Inhibition of metastatic brain cancer in Sonic Hedgehog medulloblastoma using caged nitric oxide albumin nanoparticles
Date
2023
Publisher
Frontiers Media SA
Subject
Neoplasms
Tumors
Oncology
Cancer
Carcinogens
Sonic Hedgehog
Hematogenous dissemination
Leptomeningeal dissemination
Medulloblastoma
Metastasis
Nitroxide
Tumors
Oncology
Cancer
Carcinogens
Sonic Hedgehog
Hematogenous dissemination
Leptomeningeal dissemination
Medulloblastoma
Metastasis
Nitroxide
Language
English
Abstract
Medulloblastoma is a tumor of the cerebellum that metastasizes to the leptomeninges of the central nervous system (CNS), including to forebrain and to spinal cord. The inhibitory effect of polynitroxylated albumin (PNA), a caged nitroxide nanoparticle, on leptomeningeal dissemination and metastatic tumor growth was studied in a Sonic Hedgehog transgenic mouse model. PNA treated mice showed an increased lifespan with a mean survival of 95 days (n = 6, P<0.05) compared with 71 days in controls. In primary tumors, proliferation was significantly reduced and differentiation was significantly increased (P<0.001) as shown by Ki-67+ and NeuN+ immunohistochemistry, while cells in spinal cord tumors appeared unaffected. Yet, histochemical analysis of metastatic tumor in spinal cord showed that the mean total number of cells in spinal cord was significantly reduced in mice treated with PNA compared to albumin vehicle (P<0.05). Examination of various levels of the spinal cord showed that PNA treated mice had significantly reduced metastatic cell density in the thoracic, lumbar and sacral spinal cord levels (P<0.05), while cell density in the cervical region was not significantly changed. The mechanism by which PNA may exert these effects on CNS tumors is discussed.
Source
Frontiers in Oncology, Volume 13, May 2023
Rights
Copyright © 2023 Soltys, Grausam, Messerli, Hsia and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Format
PDF
Type
Text
Identifier
Bibliographic Citation
Soltys, B. J., Grausam, K. B., Messerli, S. M., Hsia, C. J. C., & Zhao, H. (2023). Inhibition of metastatic brain cancer in Sonic Hedgehog medulloblastoma using caged nitric oxide albumin nanoparticles. In Frontiers in Oncology (Vol. 13). Frontiers Media SA. https://doi.org/10.3389/fonc.2023.1129533
Files
Collection
Citation
Soltys, B. J., Grausam, K. B., Messerli, S. M., Hsia, C. J. C., & Zhao, H., Inhibition of metastatic brain cancer in Sonic Hedgehog medulloblastoma using caged nitric oxide albumin nanoparticles. Frontiers in Oncology, Volume 13, May 2023, New York Tech Institutional Repository, accessed May 17, 2024, https://repository.nyitlibrary.org/items/show/3717
Position: 2196 (2 views)