Saliva microRNA Biomarkers of Cumulative Concussion

Author(s)

Hicks, S. D., Olympia, R. P., Onks, C., Kim, R. Y., Zhen, K. J., Fedorchak, G., DeVita, S., Rangnekar, A., Heller, M., Zwibel, H., Monteith, C., Gagnon, Z., McLoughlin, C. D., Randall, J., Madeira, M., Campbell, T. R., Fengler, E., Dretsch, M. N., Neville, C., & Middleton, F. A.

Title

Saliva microRNA Biomarkers of Cumulative Concussion

Date

2020

Publisher

MDPI AG

Subject

Biomarker
MicroRNA
Mild traumatic brain injury
Saliva
Sports-related concussion

Language

English

Abstract

Recurrent concussions increase risk for persistent post-concussion symptoms, and may lead to chronic neurocognitive deficits. Little is known about the molecular pathways that contribute to persistent concussion symptoms. We hypothesized that salivary measurement of microribonucleic acids (miRNAs), a class of epitranscriptional molecules implicated in concussion pathophysiology, would provide insights about the molecular cascade resulting from recurrent concussions. This hypothesis was tested in a case-control study involving 13 former professional football athletes with a history of recurrent concussion, and 18 age/sex-matched peers. Molecules of interest were further validated in a cross-sectional study of 310 younger individuals with a history of no concussion (n = 230), a single concussion (n = 56), or recurrent concussions (n = 24). There was no difference in neurocognitive performance between the former professional athletes and their peers, or among younger individuals with varying concussion exposures. However, younger individuals without prior concussion outperformed peers with prior concussion on three balance assessments. Twenty salivary miRNAs differed (adj. p < 0.05) between former professional athletes and their peers. Two of these (miR-28-3p and miR-339-3p) demonstrated relationships (p < 0.05) with the number of prior concussions reported by younger individuals. miR-28-3p and miR-339-5p may play a role in the pathophysiologic mechanism involved in cumulative concussion effects.

Source

International Journal of Molecular Sciences, Volume 21, Issue 20, October 2020, page 7758

Rights

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

Format

PDF

Type

Text

Bibliographic Citation

Hicks, S. D., Olympia, R. P., Onks, C., Kim, R. Y., Zhen, K. J., Fedorchak, G., DeVita, S., Rangnekar, A., Heller, M., Zwibel, H., Monteith, C., Gagnon, Z., McLoughlin, C. D., Randall, J., Madeira, M., Campbell, T. R., Fengler, E., Dretsch, M. N., Neville, C., & Middleton, F. A. (2020). Saliva microRNA Biomarkers of Cumulative Concussion. In International Journal of Molecular Sciences (Vol. 21, Issue 20, p. 7758). MDPI AG. https://doi.org/10.3390/ijms21207758

Files

ijms-21-07758-v2.pdf

Citation

Hicks, S. D., Olympia, R. P., Onks, C., Kim, R. Y., Zhen, K. J., Fedorchak, G., DeVita, S., Rangnekar, A., Heller, M., Zwibel, H., Monteith, C., Gagnon, Z., McLoughlin, C. D., Randall, J., Madeira, M., Campbell, T. R., Fengler, E., Dretsch, M. N., Neville, C., & Middleton, F. A., Saliva microRNA Biomarkers of Cumulative Concussion. International Journal of Molecular Sciences, Volume 21, Issue 20, October 2020, page 7758, New York Tech Institutional Repository, accessed September 14, 2024, https://repository.nyitlibrary.org/items/show/3724

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