ALT Positivity in Human Cancers: Prevalence and Clinical Insights
Title
ALT Positivity in Human Cancers: Prevalence and Clinical Insights
Date
2021
Publisher
MDPI AG
Subject
Alternative lengthening of telomeres
Cancers
ALT biomarkers
ATRX
DAXX
Cancers
ALT biomarkers
ATRX
DAXX
Language
English
Abstract
Many exciting advances in cancer-related telomere biology have been made in the past decade. Of these recent advances, great progress has also been made with respect to the Alternative Lengthening of Telomeres (ALT) pathway. Along with a better understanding of the molecular mechanism of this unique telomere maintenance pathway, many studies have also evaluated ALT activity in various cancer subtypes. We first briefly review and assess a variety of commonly used ALT biomarkers. Then, we provide both an update on ALT-positive (ALT+) tumor prevalence as well as a systematic clinical assessment of the presently studied ALT+ malignancies. Additionally, we discuss the pathogenetic alterations in ALT+ cancers, for example, the mutation status of ATRX and DAXX, and their correlations with the activation of the ALT pathway. Finally, we highlight important ALT+ clinical associations within each cancer subtype and subdivisions within, as well as their prognoses. We hope this alternative perspective will allow scientists, clinicians, and drug developers to have greater insight into the ALT cancers so that together, we may develop more efficacious treatments and improved management strategies to meet the urgent needs of cancer patients.
Source
Cancers, Volume 13, Issue 10, May 2021, Page 2384
Rights
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Format
PDF
Type
Text
Identifier
Bibliographic Citation
MacKenzie, D., Jr., Watters, A. K., To, J. T., Young, M. W., Muratori, J., Wilkoff, M. H., Abraham, R. G., Plummer, M. M., & Zhang, D. (2021). ALT Positivity in Human Cancers: Prevalence and Clinical Insights. In Cancers (Vol. 13, Issue 10, p. 2384). MDPI AG. https://doi.org/10.3390/cancers13102384
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Citation
MacKenzie, D., Jr., Watters, A. K., To, J. T., Young, M. W., Muratori, J., Wilkoff, M. H., Abraham, R. G., Plummer, M. M., & Zhang, D., ALT Positivity in Human Cancers: Prevalence and Clinical Insights. Cancers, Volume 13, Issue 10, May 2021, Page 2384, New York Tech Institutional Repository, accessed April 27, 2024, https://repository.nyitlibrary.org/items/show/3776
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