Neuronal Yin Yang1 in the prefrontal cortex regulates transcriptional and behavioral responses to chronic stress in mice

Author(s)

Kwon, D. Y., Xu, B., Hu, P., Zhao, Y.-T., Beagan, J. A., Nofziger, J. H., Cui, Y., Phillips-Cremins, J. E., Blendy, J. A., Wu, H., & Zhou, Z.

Title

Date

2022

Publisher

Springer Science and Business Media LLC

Subject

Animals
Behavior, Animal
Chromatin
Epigenomics
Female
Gene Expression Regulation
Male
Metabolism
Mice
Mice, Inbred C57BL
Mice, Knockout
Neurons
Prefrontal Cortex
Stress, Physiological
YY1 Transcription Factor

Language

English

Abstract

Although the synaptic alterations associated with the stress-related mood disorder major depression has been well-documented, the underlying transcriptional mechanisms remain poorly understood. Here, we perform complementary bulk nuclei- and single-nucleus transcriptome profiling and map locus-specific chromatin interactions in mouse neocortex to identify the cell type-specific transcriptional changes associated with stress-induced behavioral maladaptation. We find that cortical excitatory neurons, layer 2/3 neurons in particular, are vulnerable to chronic stress and acquire signatures of gene transcription and chromatin structure associated with reduced neuronal activity and expression of Yin Yang 1 (YY1). Selective ablation of YY1 in cortical excitatory neurons enhances stress sensitivity in both male and female mice and alters the expression of stress-associated genes following an abbreviated stress exposure. These findings demonstrate how chronic stress impacts transcription in cortical excitatory neurons and identify YY1 as a regulator of stress-induced maladaptive behavior in mice.

Source

Nature Communication, Volume 13, Issue 1, January 2022, pages 1-19

Rights

The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology. This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/ by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

Format

PDF

Type

Text

Identifier

https://repository.nyitlibrary.org/files/original/23ef88aaa474cbaa9215f628d811729d.pdf

https://doi.org/10.1038/s41467-021-27571-3

Bibliographic Citation

Kwon, D. Y., Xu, B., Hu, P., Zhao, Y.-T., Beagan, J. A., Nofziger, J. H., Cui, Y., Phillips-Cremins, J. E., Blendy, J. A., Wu, H., & Zhou, Z. (2022). Neuronal Yin Yang1 in the prefrontal cortex regulates transcriptional and behavioral responses to chronic stress in mice. In Nature Communications (Vol. 13, Issue 1). Springer Science and Business Media LLC. https://doi.org/10.1038/s41467-021-27571-3

Files

Collection

NYITCOM - Faculty Publications

Tags

adult, animal, animal behavior, animal cell, animal experiment, animal model, animal tissue, Animals, area under the curve, article, behavior, bioassay, body weight, C57BL mouse, cell, cell component, chromatin, chromatin immunoprecipitation, chromatin structure, chronic stress, confocal microscopy, controlled study, differential gene expression, down regulation, elevated zero maze, epigenetics, Epigenomics, experimental behavioral test, female, food intake, gene expression, gene expression regulation, gene mapping, gene ontology, genetic regulation, genetic transcription, genetics, genome analysis, high throughput sequencing, in situ hybridization, Inbred C57BL, Knockout, knockout mouse, locomotion, male, metabolism, Mice, mouse, neocortex, nerve cell, nerve conduction, nervous system, nesting, Neurons, nonhuman, nucleus accumbens, open field assay, physical activity, Physiological, physiological stress, prefrontal cortex, protein expression, protein fingerprinting, protein folding, real time polymerase chain reaction, real time reverse transcription polymerase chain reaction, RNA sequencing, rodent, signal transduction, single nucleus RNA sequencing, Stress, sucrose preference test, tail suspension test, transcription factor YY1, transcriptomics, upregulation, Western blotting, Yy1 protein, YY1 Transcription Factor

Citation

Kwon, D. Y., Xu, B., Hu, P., Zhao, Y.-T., Beagan, J. A., Nofziger, J. H., Cui, Y., Phillips-Cremins, J. E., Blendy, J. A., Wu, H., & Zhou, Z. , Neuronal Yin Yang1 in the prefrontal cortex regulates transcriptional and behavioral responses to chronic stress in mice. Nature Communication, Volume 13, Issue 1, January 2022, pages 1-19, New York Tech Institutional Repository, accessed April 28, 2024, https://repository.nyitlibrary.org/items/show/3788

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