Mechanisms and consequences of casein kinase II and ankyrin-3 regulation of the epithelial Na⁺ channel

]]> Cardiovascular biology
Kidney
Neurophysiology
Membrane trafficking
Ion channels
Sodium channels
Kinases
Cellular neuroscience]]> Scientific Reports, Volume 11, Issue 1, July 2021, Article 14600]]> Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.]]> https://repository.nyitlibrary.org/files/original/3e3892ed56d7f3745aff88994ae5f4a0.pdf]]> https://doi.org/10.1038/s41598-021-94118-3]]> Abd El-Aziz, T. M., Soares, A. G., Mironova, E., Boiko, N., Kaur, A., Archer, C. R., Stockand, J. D., & Berman, J. M. (2021). Mechanisms and consequences of casein kinase II and ankyrin-3 regulation of the epithelial Na+ channel. In Scientific Reports (Vol. 11, Issue 1). Springer Science and Business Media LLC. https://doi.org/10.1038/s41598-021-94118-3]]> Family medicine
Health; lacrosse
Osteopathic medicine
Performance
Primary care
Sports medicine]]> Context: Comprehensive sports medicine care goes beyond the treatment of injuries resulting from athletic activities. Ultimately, it is a competence that includes knowledge in physical therapy, training, nutrition, coaching, motivation, competition, mentoring, psychology, and spirituality that allows the physician and patient to collaborate on promoting the patient's health goals. The current literature demonstrates a lack of knowledge in the Osteopathic Primary Care Sports Medicine Model's effectiveness in performance.

Objectives: To determine whether a comprehensive osteopathic primary care sports medicine approach can improve performance and health outcomes in collegiate athletes.

Methods: A randomized controlled trial commenced just prior to the start of the lacrosse season and concluded at the end of the season. All the New York Institute of Technology (NYIT) collegiate lacrosse players were educated first in a 1-day seminar of the core competencies, and all participants had access to ask questions on their own volition. Then they were randomized into two groups, either the experimental group receiving the direct osteopathic primary care sports medicine intervention (n=18) or the control group not having active intervention (n=19). Also, the overall team winning percentage for that season was computed and compared to that for the previous years and the following year. Participants were assessed before and after the intervention with the Patient Health Questionnaire (PHQ-9), the 36-Item Short Form Survey (SF-36), custom Osteopathic Primary Care Sports Medicine questionnaire, and body fat composition, and their changes were compared between the experimental group and the control group. Collected data were analyzed using the repeated-measures analysis of variance.

Results: Thirty-seven participants were enrolled in the study. After 14 participants were excluded due to being lost to follow-up, 23 athlete records were analyzed. The winning percentage of the team was highest during the year of the study period time than in the 3 previous years and the following year. The test group did not have any statistically significant change in the PHQ-9, SF-36, custom Osteopathic Primary Care Sports Medicine questionnaire, as well as in body fat composition.

Conclusions: When used during a collegiate lacrosse season, this Osteopathic Primary Care Sports Medicine intervention did not significantly improve health outcomes. This preliminary study, despite its limitations in compliance and study population size, did demonstrate improvement in overall team performance when comparing the intervention sport season to other seasons but was not statistically significantly. Therefore, further studies are warranted to improve the understanding in this approach to athlete health outcomes and performance.

]]> Journal of Osteopathic Medicine, Volume 122, Issue 2, November 2021, pages 71-77]]> https://repository.nyitlibrary.org/files/original/5a126b18dce9e48bf5f1789d34af0825.pdf]]> https://doi.org/10.1515/jom-2021-0083]]> Rao, N. C., Zwibel, H., Berezanskaya, J., Pena, P., & Jung, M.-K. (2021). A comparative study of the effectiveness of an osteopathic primary care sports medicine led intervention on performance in men’s collegiate lacrosse players. In Journal of Osteopathic Medicine (Vol. 122, Issue 2, pp. 71–77). Walter de Gruyter GmbH. https://doi.org/10.1515/jom-2021-0083]]>
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Cetacean vertebrae
Failed predation
Harmful algal bloom
Miocene
Otodus megalodon
Seizure
Shear-compression fracture
Acid
Algal bloom
Cetacean
Compression
Fracture
Miocene
Pathology
Predation
Shark
Shear
Tooth
Toxicity]]>
A single megatoothed shark tooth from Otodus megalodon was found with the vertebra. It is not known if the tooth came to be there serendipitously, or if it was associated because it was lost as a result of the possible originating failed predation event, or during a final successful predation or subsequent scavenging event.

The fractures are severe and unlikely to have had an endogenous origin like convulsions, seizures, or spasms. Seizures can cause vertebral fractures in humans, including elderly adults with poor bone health as well as physically fit younger individuals. Seizures causing injuries of this magnitude have not been observed in cetaceans, though domoic acid toxicity from harmful algal blooms are known to cause seizures in cetaceans, and are implicated in the deaths of neonatal skim-feeding mysticetes. It is unlikely, but possible, that a large mysticete would be affected by domoic acid toxicity to the point of a spinal fracture-causing seizure. Similarly, protozoal infections are known to cause seizures in cetaceans, though physical diagnosis of this is impossible in a fossil. Partly healed bone fractures of the face from possible collisions with the seafloor have been reported from fossil mysticetes of shallower regions of this fauna, but a spinal fracture this far back in the spinal column seems unlikely to be the result of a seafloor collision. Even though the cause of the vertebral hyperflexion and resulting trauma is unknown, a plausible cause was a crushing ambush delivered by a macropredatory shark or macroraptorial physeteroid. In spite of extant cetaceans being subjected to anthropogenically-induced trauma, which include vessel-strike blunt force injuries of many different kinds, shear-compression fractures and periosteal reactions like the ones detailed here have not yet been reported in extant cetaceans. Therefore, we consider the fracture as likely due to an impact from a predator, such as Otodus megalodon, or possibly from seizures due to a harmful algal bloom and resulting domoic acid toxicity. In either scenario, the cetacean survived.]]> Palaeontologia Electronica, Article 25.3.a28, September 2022]]> https://repository.nyitlibrary.org/files/original/625ed29d2da781f30e49559144d0beca.pdf]]> https://doi.org/10.26879/1171]]> Anatomic Landmarks / anatomy & histology
Animals
Biological Evolution
Birds / anatomy & histology
Models, Anatomic
Phenotype
Reptiles
Skull]]> Integrative Organismal Biology, Volume 1, Issue 1, July 2019]]> © The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

]]> https://repository.nyitlibrary.org/files/original/0d49a32ca2112ca28ed0bda2ed7a8f85.pdf]]> https://doi.org/10.1093/iob/obz016]]> Bardua, C., Felice, R. N., Watanabe, A., Fabre, A.-C., & Goswami, A. (2019). A Practical Guide to Sliding and Surface Semilandmarks in Morphometric Analyses. In Integrative Organismal Biology (Vol. 1, Issue 1). Oxford University Press (OUP). https://doi.org/10.1093/iob/obz016]]> Journal of Vertebrate Paleontology, vol. 40, no. 1, Jan. 2020, pp. 1–21]]> This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.]]> https://repository.nyitlibrary.org/files/original/f67eee8af23a2dc21eb45398705ca87e.pdf

https://doi.org/10.1080/02724634.2020.1767638]]> Cossette, A. P., & Brochu, C. A. (2020). A systematic review of the giant alligatoroidDeinosuchusfrom the Campanian of North America and its implications for the relationships at the root of Crocodylia. In Journal of Vertebrate Paleontology (Vol. 40, Issue 1, p. e1767638). Informa UK Limited. https://doi.org/10.1080/02724634.2020.1767638]]>
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Elastic energy
Force
Locomotion
Power
Work]]> Journal of Human Evolution Volune 168, July 2022, page 103195]]> This article is available under the Creative Commons CC-BY-NC-ND license and permits non-commercial use of the work as published, without adaptation or alteration provided the work is fully attributed.]]> https://repository.nyitlibrary.org/files/original/f7057fd6ee58739b43e0eb1fc5fe61b2.pdf]]> https://doi.org/10.1016/j.jhevol.2022.103195]]> O’Neill, M. C., Demes, B., Thompson, N. E., Larson, S. G., Stern, J. T., Jr., & Umberger, B. R. (2022). Adaptations for bipedal walking: Musculoskeletal structure and three-dimensional joint mechanics of humans and bipedal chimpanzees (Pan troglodytes). In Journal of Human Evolution (Vol. 168, p. 103195). Elsevier BV. https://doi.org/10.1016/j.jhevol.2022.103195]]> Chordal Structure
Comprehensive Computational Model
Fluid-Structure Interaction
Heart Valve
Smooth Particle Hydrodynamics]]> Biology, Volume 10, Issue 6, June 2021, page 536]]> © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).]]> https://repository.nyitlibrary.org/files/original/5f4d0a05b468fb97ccfa623ce3e3a322.pdf]]> https://doi.org/10.3390/biology10060536]]> Toma, M., Guru, S. K., Wu, W., Ali, M., & Ong, C. W. (2021). Addressing Discrepancies between Experimental and Computational Procedures. In Biology (Vol. 10, Issue 6, p. 536). MDPI AG. https://doi.org/10.3390/biology10060536]]> Contractility
Heart failure
T-tubules
Triiodothyronine]]> Pre-clinical animal studies have shown that triiodothyronine (T3) replacement therapy improves cardiac contractile function after myocardial infarction (MI). We hypothesized that T3 treatment could prevent adverse post-infarction cardiomyocyte remodeling by maintaining transverse-tubule (TT) structures, thus improving calcium dynamics and contractility.

Methods

Myocardial infarction (MI) or sham surgeries were performed on female Sprague-Dawley rats (aged 12 wks), followed by treatment with T3 (5μg/kg/d) or vehicle in drinking water for 16 wks (n = 10–11/group). After in vivo echocardiographic and hemodynamic analyses, left ventricular myocytes were isolated by collagenase digestion and simultaneous calcium and contractile transients in single cardiomyocytes were recorded using IonOptix imaging. Live cardiomyocytes were stained with AlexaFluor-488 conjugated wheat germ agglutinin (WGA-488) or di-8-ANEPPS, and multiple z-stack images per cell were captured by confocal microscopy for analysis of TT organization. RTqPCR and immunoblot approaches determined expression of TT proteins.

Results

Echocardiography and in vivo hemodynamic measurements showed significant improvements in systolic and diastolic function in T3- vs vehicle-treated MI rats. Isolated cardiomyocyte analysis showed significant dysfunction in measurements of myocyte relengthening in MI hearts, and improvements with T3 treatment: max relengthening velocity (Vmax, um/s), 2.984 ± 1.410 vs 1.593 ± 0.325, p < 0.05 and time to Vmax (sec), 0.233 ± 0.037 vs 0.314 ± 0.019, p < 0.001; MI + T3 vs MI + Veh, respectively. Time to peak contraction was shortened by T3 treatment (0.161 ± 0.021 vs 0.197 ± 0.011 s., p < 0.01; MI + T3 vs MI + Veh, respectively). Analysis of TT periodicity of WGA- or ANEPPS-stained cardiomyocytes indicated significant TT disorganization in MI myocytes and improvement with T3 treatment (transverse-oriented tubules (TE%): 9.07 ± 0.39 sham, 6.94 ± 0.67 MI + Veh and 8.99 ± 0.38 MI + T3; sham vs MI + Veh, p < 0.001; MI + Veh vs MI + T3, p < 0.01). Quantitative RT-PCR showed that reduced expression of BIN1 (Bridging integrator-1), Jph2 (junctophilin-2), RyR2 (ryanodine receptor) and Ca_v1.2 (L-type calcium channel) in the failing myocardium were increased by T3 and immunoblot analysis further supporting a potential T3 effect on the TT-associated proteins, BIN1 and Jph2.

In conclusion, low dose T3 treatment initiated immediately after myocardial infarction attenuated adverse TT remodeling, improved calcium dynamics and contractility, thus supporting the potential therapeutic utility of T3 treatment in heart failure.

]]> Molecular Medicine, Volume 25, Issue 1, December 2019]]> Reprints and Permissions.]]> https://repository.nyitlibrary.org/files/original/92cc176f4f16e234d4fcc18ed703933c.pdf]]> https://doi.org/10.1186/s10020-019-0120-3]]> An, S., Gilani, N., Huang, Y., Muncan, A., Zhang, Y., Tang, Y.-D., Gerdes, A. M., & Ojamaa, K. (2019). Adverse transverse-tubule remodeling in a rat model of heart failure is attenuated with low-dose triiodothyronine treatment. In Molecular Medicine (Vol. 25, Issue 1). Springer Science and Business Media LLC. https://doi.org/10.1186/s10020-019-0120-3]]> Cancers
ALT biomarkers
ATRX
DAXX]]> Many exciting advances in cancer-related telomere biology have been made in the past decade. Of these recent advances, great progress has also been made with respect to the Alternative Lengthening of Telomeres (ALT) pathway. Along with a better understanding of the molecular mechanism of this unique telomere maintenance pathway, many studies have also evaluated ALT activity in various cancer subtypes. We first briefly review and assess a variety of commonly used ALT biomarkers. Then, we provide both an update on ALT-positive (ALT+) tumor prevalence as well as a systematic clinical assessment of the presently studied ALT+ malignancies. Additionally, we discuss the pathogenetic alterations in ALT+ cancers, for example, the mutation status of ATRX and DAXX, and their correlations with the activation of the ALT pathway. Finally, we highlight important ALT+ clinical associations within each cancer subtype and subdivisions within, as well as their prognoses. We hope this alternative perspective will allow scientists, clinicians, and drug developers to have greater insight into the ALT cancers so that together, we may develop more efficacious treatments and improved management strategies to meet the urgent needs of cancer patients.]]> Cancers, Volume 13, Issue 10, May 2021, Page 2384]]> All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited.]]> https://repository.nyitlibrary.org/files/original/45fb0fa9261ac518b5a1a88b1977f092.pdf]]> https://doi.org/10.3390/cancers13102384]]> MacKenzie, D., Jr., Watters, A. K., To, J. T., Young, M. W., Muratori, J., Wilkoff, M. H., Abraham, R. G., Plummer, M. M., & Zhang, D. (2021). ALT Positivity in Human Cancers: Prevalence and Clinical Insights. In Cancers (Vol. 13, Issue 10, p. 2384). MDPI AG. https://doi.org/10.3390/cancers13102384]]> Cancer metabolism
Colorectal cancer stem cells
Patient‐derived xenograft]]> Colorectal cancer (CRC) is the third most commonly diagnosed cancer in males and the second in females worldwide in 2012. In the past 20 years, strong evidence suggests that cancer stem cells are the main culprit of cancer metastasis, chemotherapy resistance, and relapse.

Methods
To further understand the unique biological properties of cancer stem cells and uncover novel molecular targets to eradicate them, we first established a panel of patient-derived xenograft (PDX) tumor models using tumors surgically removed from human colorectal cancer patients. We then isolated CRC cancer stem cells based on their ALDH activity using fluorescent-activated cell sorting (FACS) and characterized their metabolic properties.

Results
Interestingly, we found that the CRC cancer stem cells (ie, CRC cells with higher ALDH activity, or ALDH+) express higher level of antioxidant genes and have lower level of reactive oxygen species (ROS) than non-CRC cancer stem cells (ie, CRC cells with lower ALDH activity, or ALDH−). The CRC cancer stem cells also possess more mitochondria mass and show higher mitochondrial activity. More intriguingly, we observed higher AMP-activated protein kinase (AMPK) activities in these CRC cancer stem cells. Inhibition of the AMPK activity using 2 AMPK inhibitors, Compound C and Iodotubercidin, preferentially induces cell death in CRC cancer stem cells.

Conclusion
We propose that AMPK inhibitors may help to eradicate the CRC cancer stem cells and prevent the relapse of CRCs.]]> Animal Models and Experimental Medicine, Volume 1, Issue 2, July 2018, pages 134-142]]> https://repository.nyitlibrary.org/files/original/5a126b18dce9e48bf5f1789d34af0825.pdf]]> https://doi.org/10.3390/biology10050374]]> Guo, B., Han, X., Tkach, D., Huang, S., & Zhang, D. (2018). AMPK promotes the survival of colorectal cancer stem cells. In Animal Models and Experimental Medicine (Vol. 1, Issue 2, pp. 134–142). Wiley. https://doi.org/10.1002/ame2.12016]]> Global Health
High-Income Countries (HIC)
Low-to-Middle Income Countries (LMICs)
Sustainable Development Goals (SDGs)
Teaching & Learning Methods]]> Journal of Global Awareness, vol. 3, no. 2, Dec. 2022, pp. 1–20]]> karniks@stjohns.edu, fuchsc@stjohns.edu.]]> https://repository.nyitlibrary.org/files/original/7c7f0d85a98dd711898476adf47b3389.pdf

https://doi.org/10.24073/jga/3/02/05]]> Oji, V., Knight, C., Mahatara, R., & Oladoyin, V. (2022). An Ethics Assessment Model for Teaching Global Health Program and Policy Implementation. In Journal of Global Awareness (Vol. 3, Issue 2). St. John’s University. https://doi.org/10.24073/jga/3/02/05]]> Analgesics administration & dosage therapeutic use
Animals
Disease Models, Animal
Hyperalgesia drug therapy etiology
Index Medicus
Male
Nerve Tissue Proteins administration & dosage therapeutic use
Neuralgia drug therapy etiology
Pain Measurement
Pain Threshold drug effects
Peripheral Nerve Injuries complications
Rats
Rats, Sprague-Dawley
Reproducibility of Results]]> Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.]]> https://repository.nyitlibrary.org/files/original/7d1ea959754f0f1c17fafe5f99d1a2b7.pdf

https://doi.org/10.1097/j.pain.0000000000001569]]>
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Gallus
Diffusible iodine-based contrast-enhanced computed tomography
Geometric morphometrics
Micro-computed tomography
Neuroanatomy]]> Journal of Anatomy, Volume 234, Issue 3, December 2018, pages 291-305]]> https://repository.nyitlibrary.org/files/original/6cf271c0c7cc2bfcfe261ec3fbe66313.pdf]]> https://doi.org/10.1111/joa.12918]]> Watanabe, A., Gignac, P. M., Balanoff, A. M., Green, T. L., Kley, N. J., & Norell, M. A. (2018). Are endocasts good proxies for brain size and shape in archosaurs throughout ontogeny? In Journal of Anatomy (Vol. 234, Issue 3, pp. 291–305). Wiley. https://doi.org/10.1111/joa.12918]]> Force loads
Orthostatic hypotension
Statistical analysis]]> Materials, Volume 15, Issue 9, April 2022, page 3116]]> © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).]]> https://repository.nyitlibrary.org/files/original/351c173ce5a4f2c097d23991543348db.pdf]]> https://doi.org/10.3390/ma15093116]]> Syed, F., Jose, R., Devine, T., Coletti, C., & Toma, M. (2022). Assessment of Abdominal Constrictor’s Forces for Informing Computational Models of Orthostatic Hypotension. In Materials (Vol. 15, Issue 9, p. 3116). MDPI AG. https://doi.org/10.3390/ma15093116]]> Biological Evolution
Eutheria anatomy & histology
Female
Fossils
Index Medicus
Phylogeny
Rodentia
Skull anatomy & histology]]> Science, Volume 378, Issue 6618, October 2022, pages 377-383]]> Copyright © 2022 the authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original US government works. https://www.science.org/about/science-licenses-journal-article-reuse]]> https://repository.nyitlibrary.org/files/original/e9b15442736432b2304a1d23eaac5f32.pdf]]> https://doi.org/10.1126/science.abm7525]]> Goswami, A., Noirault, E., Coombs, E. J., Clavel, J., Fabre, A.-C., Halliday, T. J. D., Churchill, M., Curtis, A., Watanabe, A., Simmons, N. B., Beatty, B. L., Geisler, J. H., Fox, D. L., & Felice, R. N. (2022). Attenuated evolution of mammals through the Cenozoic. In Science (Vol. 378, Issue 6618, pp. 377–383). American Association for the Advancement of Science (AAAS). https://doi.org/10.1126/science.abm7525]]> Physiology
Experimental pharmacology
T3
Gene expression
Heart failure
Hypothyroidism
Thyroid hormones]]> Background: Cardiac re-expression of fetal genes in patients with heart failure (HF) suggests the presence of low cardiac tissue thyroid hormone (TH) function. However, serum concentrations of T3 and T4 are often normal or subclinically low, necessitating an alternative serum biomarker for low cardiac TH function to guide treatment of these patients. The clinical literature suggests that serum Brain Natriuretic Peptide (BNP) levels are inversely associated with serum triiodo-L-thyronine (T3) levels. The objective of this study was to investigate BNP as a potential serum biomarker for TH function in the heart.

Methods: Two animal models of thyroid hormone deficiency: (1) 8-weeks of propyl thiouracil-induced hypothyroidism (Hypo) in adult female rats were subsequently treated with oral T3 (10 μg/kg/d) for 3, 6, or 14 days; (2) HF induced by coronary artery ligation (myocardial infarction, MI) in adult female rats was treated daily with low dose oral T3 (5 μg/kg/d) for 8 or 16 wks.

Results: Six days of T3 treatment of Hypo rats normalized most cardiac functional parameters. Serum levels of BNP increased 5-fold in Hypo rats, while T3 treatment normalized BNP by day 14, showing a significant inverse relationship between serum BNP and free or total T3 concentrations. Myocardial BNP mRNA was increased 2.5-fold in Hypo rats and its expression was decreased to normal values by 14 days of T3 treatment. Measurements of hemodynamic function showed significant dysfunction in MI rats after 16 weeks, with serum BNP increased by 4.5-fold and serum free and total T3 decreased significantly. Treatment with T3 decreased serum BNP while increasing total T3 indicating an inverse correlation between these two biologic factors (r² = 0.676, p < 0.001). Myocardial BNP mRNA was increased 5-fold in MI rats which was significantly decreased by T3 over 8 to 16 week treatment periods.

Conclusions: Results from the two models of TH dysfunction confirmed an inverse relationship between tissue and serum T3 and BNP, such that the reduction in serum BNP could potentially be utilized to monitor efficacy and dosing of T3 treatment. Thus, serum BNP may serve as a reliable biomarker for cardiac TH function.

]]> Frontiers in Physiology, Volume 11, July 2020]]> Copyright © 2020 Wang, Ojamaa, Samuels, Gilani, Zhang, An, Zhang, Tang, Askari and Gerdes. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.]]> https://repository.nyitlibrary.org/files/original/6aa336bf64feefd5da01a6f4a4b4382a.pdf

]]> https://doi.org/10.3389/fphys.2020.00729]]> Wang, K., Ojamaa, K., Samuels, A., Gilani, N., Zhang, K., An, S., Zhang, Y., Tang, Y.-D., Askari, B., & Gerdes, A. M. (2020). BNP as a New Biomarker of Cardiac Thyroid Hormone Function. In Frontiers in Physiology (Vol. 11). Frontiers Media SA. https://doi.org/10.3389/fphys.2020.00729]]> Randomised controlled trial
Sitting time
Walking]]>

Objective The effect of prolonged sitting on executive function and performance in competitive esports players are unknown. This study aimed to evaluate executive function following a 6 min bout of walking or rest during prolonged gaming in competitive esports players.

Methods 12 men and 9 women completed three separate 2-hour gaming session days assigned in randomised order consisting of a 6 min walk break, 6 min rest break and continuous before and after each session. Postintervention participant exit survey data were also collected.

Results The walk condition produced a significantly faster mean solution time (7613.6±3060.5 min, p=0.02) and planning time (5369.0±2802.09, p=0.04) compared with the resting condition (9477±3547.4; 6924±3247.7) and continuous play (8200.0±3031.6; 5862.7±2860.7). The rest condition resulted in the slowest mean solution time (9477.0±3547.4) and planning time (6924.0±3247.7), with the continuous play resulting in a faster mean solution time (8200.1±3031.6) and planning time (5862.7±2860.7) than the rest condition. There was no impact on game performance in any of the conditions. However, over 70% of participants felt that the walk break improved esports performance.

Conclusions Reducing sit time and breaking up prolonged sitting have acute and chronic health benefits. This study provides evidence that a 6 min walking break in the middle of 2 hours of gameplay allows gamers to have these health benefits while improving processing speed and executive function.

Trial registration number NCT04674436.

]]> ]]> BMJ Open Sport & Exercise Medicine, Volume 7, Issue 3, August 2021]]> This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.]]> https://repository.nyitlibrary.org/files/original/383d15ee26866f0c85c7d085dca55d13.pdf]]> https://doi.org/10.1136/bmjsem-2021-001118]]> DiFrancisco-Donoghue, J., Jenny, S. E., Douris, P. C., Ahmad, S., Yuen, K., Hassan, T., Gan, H., Abraham, K., & Sousa, A. (2021). Breaking up prolonged sitting with a 6 min walk improves executive function in women and men esports players: a randomised trial. In BMJ Open Sport & Exercise Medicine (Vol. 7, Issue 3, p. e001118). BMJ. https://doi.org/10.1136/bmjsem-2021-001118]]>
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Caffeine
Dantrolene
Dobutamine
Ventricular arrhythmia]]>

Background

Bidirectional ventricular tachycardia (BD-VT) is an intriguing arrhythmia, characterized by a beat-to-beat alternation of the QRS polarity on electrocardiogram. Currently there is no simple BD-VT animal model.

Objective

We report a simple animal model of BD-VT induced by caffeine and dobutamine (C+D) challenge in normal rats in which the arrhythmia can be attenuated by dantrolene (a ryanodine receptor stabilizer) treatment, but not by the pacemaker channel blocker ivabradine treatment.

Methods

Adult (4–5 months old) Sprague-Dawley rats (both sexes) were randomized into C+D (n = 8, received caffeine 120 mg/kg intraperitoneally [IP] and dobutamine 60 μg/kg IP, sequentially) and control (n = 8) groups. In addition, a group of 7 rats were pretreated with dantrolene (10 mg/kg, IP) 30 minutes before the C+D challenge and another group of 8 rats were pretreated with ivabradine (5 mg/kg, IP) 30 minutes before the C+D challenge.

Results

C+D challenge induced spontaneous premature ventricular contractions (PVCs) in 7 of 8 rats and BD-VT (lasted 4.3 ± 2.9 minutes, terminated spontaneously) in 6 of 8 (75%) rats. No ventricular arrhythmia was induced in the control group (P < .05 vs C+D group). Dantrolene treatment significantly decreased BD-VT (1 of 7 rats in the Dantrolene+C+D group vs 6 of 8 rats in C+D group, P < .05). Ivabradine treatment did not affect C+D-induced BD-VT (7 of 8 rats in the Ivabradine+C+D group vs 6 of 8 in the C+D group, P > .05).

Conclusion

Caffeine and dobutamine challenge induces BD-VT in a majority of normal rats. Stabilizing cardiac ryanodine receptors with dantrolene treatment can significantly decrease the occurrence of BD-VT, but pacemaker channel blocker ivabradine treatment does not have effect in this animal model.

]]> Heart Rhythm O2, Volume 1, Issue 5, December 2020, pages 359-367]]> Copyright

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]]> https://repository.nyitlibrary.org/files/original/667c55996f468c6e5304c4e1655510f0.pdf]]> https://doi.org/10.1016/j.hroo.2020.08.005]]> Zhang, C., & Zhang, Y. (2020). Caffeine and dobutamine challenge induces bidirectional ventricular tachycardia in normal rats. In Heart Rhythm O2 (Vol. 1, Issue 5, pp. 359–367). Elsevier BV. https://doi.org/10.1016/j.hroo.2020.08.005]]> Cannabidiol
Cannbinoids
Anti-cancer drug]]> Cancers, Volume 12, Issue 11, October 2020, page 3203]]> © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).]]> https://repository.nyitlibrary.org/files/original/247fa735fc0f1dbe794c4196fae1a8d1.pdf]]> https://doi.org/10.3390/cancers12113203]]> Seltzer, E. S., Watters, A. K., MacKenzie, D., Jr., Granat, L. M., & Zhang, D. (2020). Cannabidiol (CBD) as a Promising Anti-Cancer Drug. In Cancers (Vol. 12, Issue 11, p. 3203). MDPI AG. https://doi.org/10.3390/cancers12113203]]>
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Arrhythmias, Cardiac etiology metabolism prevention & control
Body Weight physiology
Caloric Restriction adverse effects methods trends
Calorie restriction
Cardiotonic Agents administration & dosage
Fasting
Female
Heart
Index Medicus
Long noncoding RNA
Male
Mice
Mice, Inbred C57BL
RNA, Long Noncoding biosynthesis
Starvation
Thyroid hormones
Triiodothyronine administration & dosage]]> https://repository.nyitlibrary.org/files/original/4063dd6e7acab4eec26bce686d3667a4.pdf]]> https://doi.org/10.1016/j.biopha.2020.110657]]> ]]>