2 20 113 https://repository.nyitlibrary.org/files/original/c2055dea2f40a4749e5cf2baea939f33.pdf 53123b7a2e0afb096705d720d0b71acd Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource NYITCOM - Faculty Publications Publication Book or Journal Article published by New York Tech Facility. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Novel Transcriptomic Interactomes of Noncoding RNAs in the Heart under Altered Thyroid Hormonal States Date A point or period of time associated with an event in the lifecycle of the resource 2023 Identifier An unambiguous reference to the resource within a given context <a href="https://repository.nyitlibrary.org/files/original/c2055dea2f40a4749e5cf2baea939f33.pdf">https://repository.nyitlibrary.org/files/original/c2055dea2f40a4749e5cf2baea939f33.pdf</a> <a href="https://doi.org/10.3390/ijms24076560">https://doi.org/10.3390/ijms24076560</a> Creator An entity primarily responsible for making the resource Rajagopalan, V., Chakraborty, S., & Lin, R. Publisher An entity responsible for making the resource available MDPI Subject The topic of the resource Cancer Heart Interactome Noncoding RNAs Thyroid hormones Transcriptome Language A language of the resource English Abstract A summary of the resource. Noncoding RNAs are emerging as vital players in cardiovascular diseases. Thyroid hormones (THs) are crucial for cardiovascular survival; however, correction of systemic hypothyroidism (low serum THs) may not improve cardiac tissue-level hypothyroidism or cardiac function. Mechanistically, the understanding of noncoding transcriptomic interactions influencing TH-mediated cardiac effects is unclear. Adult C57BL/6J mixed-sex mice were randomized into Control, Hypothyroid (HypoTH), Hyperthyroid (HyperTH), and HypoTH-Triiodothyronine restoration groups. Physiological, morphological, biochemical, molecular, and whole transcriptomic studies and appropriate statistical analyses were performed. HypoTH showed significant atrophy, depressed cardiac function, and decreased serum THs versus controls, and Triiodothyronine supplementation restored them. HyperTH significantly increased serum THs with hypertrophy. Real-time PCR showed significantly altered inflammatory and immune lncRNAs. The transcriptomic sequencing revealed significant differential expressions of lncRNAs, miRNAs, and mRNAs. Eleven novel circRNAs significantly decreased with increased THs. Multiple pathways were GO-/KEGG-enriched, including cardiac, thyroid, cancer, mitochondrial, inflammatory, adrenergic, metabolic, immune-mediated, vesicular, etc. We also uncovered significant novel co-expression and interactions of lncRNA-miRNA, lncRNA-miRNA-mRNA, lncRNA-mRNA, circRNA-miRNA, and miRNA-mRNA, and splicing events. This includes a novel pathway by which the predominant cardiac TH receptor alpha may interact with specific lncRNAs and miRNAs. This is the first study reporting a comprehensive transcriptome-wide interactome in the cardiac-thyroid axis. Source A related resource from which the described resource is derived <em>International Journal of Molecular Sciences</em>, Volume 24, Issue 7, March 2023, page 6560 Rights Information about rights held in and over the resource <span>© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (</span><a href="https://creativecommons.org/licenses/by/4.0/" target="_blank" rel="noreferrer noopener">https://creativecommons.org/licenses/by/4.0/</a><span>).</span> Format The file format, physical medium, or dimensions of the resource PDF Type The nature or genre of the resource Text Bibliographic Citation A bibliographic reference for the resource. Recommended practice is to include sufficient bibliographic detail to identify the resource as unambiguously as possible. <span>Rajagopalan, V., Chakraborty, S., &amp; Lin, R. (2023). Novel Transcriptomic Interactomes of Noncoding RNAs in the Heart under Altered Thyroid Hormonal States. In International Journal of Molecular Sciences (Vol. 24, Issue 7, p. 6560). MDPI AG. <a href="https://doi.org/10.3390/ijms24076560">https://doi.org/10.3390/ijms24076560</a></span> cancer heart interactome noncoding RNAs thyroid hormones transcriptome https://repository.nyitlibrary.org/files/original/23ef88aaa474cbaa9215f628d811729d.pdf 2f23a0493b4b3102d9c76469f464fa69 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource NYITCOM - Faculty Publications Publication Book or Journal Article published by New York Tech Facility. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Neuronal Yin Yang1 in the prefrontal cortex regulates transcriptional and behavioral responses to chronic stress in mice Identifier An unambiguous reference to the resource within a given context https://repository.nyitlibrary.org/files/original/23ef88aaa474cbaa9215f628d811729d.pdf <a href="https://doi.org/10.1038/s41467-021-27571-3">https://doi.org/10.1038/s41467-021-27571-3</a> Format The file format, physical medium, or dimensions of the resource PDF Rights Information about rights held in and over the resource The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology. This is an open-access article distributed under the terms of the Creative Commons Attribution License (<a href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/ by/4.0/</a>), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Creator An entity primarily responsible for making the resource Kwon, D. Y., Xu, B., Hu, P., Zhao, Y.-T., Beagan, J. A., Nofziger, J. H., Cui, Y., Phillips-Cremins, J. E., Blendy, J. A., Wu, H., & Zhou, Z. Date A point or period of time associated with an event in the lifecycle of the resource 2022 Language A language of the resource English Subject The topic of the resource Animals Behavior, Animal Chromatin Epigenomics Female Gene Expression Regulation Male Metabolism Mice Mice, Inbred C57BL Mice, Knockout Neurons Prefrontal Cortex Stress, Physiological YY1 Transcription Factor Source A related resource from which the described resource is derived <em>Nature Communication</em>, Volume 13, Issue 1, January 2022, pages 1-19 Abstract A summary of the resource. Although the synaptic alterations associated with the stress-related mood disorder major depression has been well-documented, the underlying transcriptional mechanisms remain poorly understood. Here, we perform complementary bulk nuclei- and single-nucleus transcriptome profiling and map locus-specific chromatin interactions in mouse neocortex to identify the cell type-specific transcriptional changes associated with stress-induced behavioral maladaptation. We find that cortical excitatory neurons, layer 2/3 neurons in particular, are vulnerable to chronic stress and acquire signatures of gene transcription and chromatin structure associated with reduced neuronal activity and expression of Yin Yang 1 (YY1). Selective ablation of YY1 in cortical excitatory neurons enhances stress sensitivity in both male and female mice and alters the expression of stress-associated genes following an abbreviated stress exposure. These findings demonstrate how chronic stress impacts transcription in cortical excitatory neurons and identify YY1 as a regulator of stress-induced maladaptive behavior in mice. Publisher An entity responsible for making the resource available Springer Science and Business Media LLC Bibliographic Citation A bibliographic reference for the resource. Recommended practice is to include sufficient bibliographic detail to identify the resource as unambiguously as possible. <span>Kwon, D. Y., Xu, B., Hu, P., Zhao, Y.-T., Beagan, J. A., Nofziger, J. H., Cui, Y., Phillips-Cremins, J. E., Blendy, J. A., Wu, H., &amp; Zhou, Z. (2022). Neuronal Yin Yang1 in the prefrontal cortex regulates transcriptional and behavioral responses to chronic stress in mice. In Nature Communications (Vol. 13, Issue 1). Springer Science and Business Media LLC. <a href="https://doi.org/10.1038/s41467-021-27571-3">https://doi.org/10.1038/s41467-021-27571-3</a></span> Type The nature or genre of the resource Text adult animal animal behavior animal cell animal experiment animal model animal tissue Animals area under the curve article behavior bioassay body weight C57BL mouse cell cell component chromatin chromatin immunoprecipitation chromatin structure chronic stress confocal microscopy controlled study differential gene expression down regulation elevated zero maze epigenetics Epigenomics experimental behavioral test female food intake gene expression gene expression regulation gene mapping gene ontology genetic regulation genetic transcription genetics genome analysis high throughput sequencing in situ hybridization Inbred C57BL Knockout knockout mouse locomotion male metabolism Mice mouse neocortex nerve cell nerve conduction nervous system nesting Neurons nonhuman nucleus accumbens open field assay physical activity Physiological physiological stress prefrontal cortex protein expression protein fingerprinting protein folding real time polymerase chain reaction real time reverse transcription polymerase chain reaction RNA sequencing rodent signal transduction single nucleus RNA sequencing Stress sucrose preference test tail suspension test transcription factor YY1 transcriptomics upregulation Western blotting Yy1 protein YY1 Transcription Factor https://repository.nyitlibrary.org/files/original/0f3bc12089774adc10ecddcd37e4a624.pdf ebba7cab0319e06ca7625ab2e49ac477 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource NYITCOM - Faculty Publications Publication Book or Journal Article published by New York Tech Facility. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Pre-clinical safety and therapeutic efficacy of a plant-based alkaloid in a human colon cancer xenograft model Identifier An unambiguous reference to the resource within a given context https://repository.nyitlibrary.org/files/original/0f3bc12089774adc10ecddcd37e4a624.pdf <a href="https://doi.org/10.1038/s41420-022-00936-3">https://doi.org/10.1038/s41420-022-00936-3</a> Creator An entity primarily responsible for making the resource Freeling, J. L., Scholl, J. L., Eikanger, M., Knoblich, C., Potts, R. A., Anderson, D. J., Rower, J. E., Farjoo, M. H., Zhao, H., Pillatzki, A., & Rezvani, K. Date A point or period of time associated with an event in the lifecycle of the resource 2022 Abstract A summary of the resource. A high-throughput drug screen revealed that veratridine (VTD), a natural plant alkaloid, induces expression of the anti-cancer protein UBXN2A in colon cancer cells. UBXN2A suppresses mortalin, a heat shock protein, with dominant roles in cancer development including epithelial-mesenchymal transition (EMT), cancer cell stemness, drug resistance, and apoptosis. VTD-dependent expression of UBXN2A leads to the deactivation of mortalin in colon cancer cells, making VTD a potential targeted therapy in malignant tumors with high levels of mortalin. VTD was used clinically for the treatment of hypertension in decades past. However, the discovery of newer antihypertensive drugs and concerns over potential neuro- and cardiotoxicity ended the use of VTD for this purpose. The current study aims to determine the safety and efficacy of VTD at doses sufficient to induce UBXN2A expression in a mouse model. A set of flow-cytometry experiments confirmed that VTD induces both early and late apoptosis in a dose-dependent manner. In vivo intraperitoneal (IP) administration of VTD at 0.1 mg/kg every other day (QOD) for 4 weeks effectively induced expression of UBXN2A in the small and large intestines of mice. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) assays on tissues collected from VTD-treated animals demonstrated VTD concentrations in the low pg/mg range. To address concerns regarding neuro- and cardiotoxicity, a comprehensive set of behavioral and cardiovascular assessments performed on C57BL/6NHsd mice revealed that VTD generates no detectable neurotoxicity or cardiotoxicity in animals receiving 0.1 mg/kg VTD QOD for 30 days. Finally, mouse xenograft experiments in athymic nude mice showed that VTD can suppress tumor growth. The main causes for the failure of experimental oncologic drug candidates are lack of sufficient safety and efficacy. The results achieved in this study support the potential utility of VTD as a safe and efficacious anti-cancer molecule. Source A related resource from which the described resource is derived <i>Cell Death Discovery</i><span>, Volume 8, Issue 1, March 2022</span> Rights Information about rights held in and over the resource <b>Open Access</b><span> This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution, and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third-party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit </span><a href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</a><span>.</span> Format The file format, physical medium, or dimensions of the resource PDF Publisher An entity responsible for making the resource available Springer Science and Business Media LLC Subject The topic of the resource Drug development Drug safety Language A language of the resource English Type The nature or genre of the resource Text Bibliographic Citation A bibliographic reference for the resource. Recommended practice is to include sufficient bibliographic detail to identify the resource as unambiguously as possible. <span>Freeling, J. L., Scholl, J. L., Eikanger, M., Knoblich, C., Potts, R. A., Anderson, D. J., Rower, J. E., Farjoo, M. H., Zhao, H., Pillatzki, A., &amp; Rezvani, K. (2022). Pre-clinical safety and therapeutic efficacy of a plant-based alkaloid in a human colon cancer xenograft model. In Cell Death Discovery (Vol. 8, Issue 1). Springer Science and Business Media LLC. <a href="https://doi.org/10.1038/s41420-022-00936-3">https://doi.org/10.1038/s41420-022-00936-3</a></span> https://repository.nyitlibrary.org/files/original/81e730c6a734f4b58cfba5085775b70e.pdf aafcd8cca7b7d83f444cd94e65187cbd Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource NYITCOM - Faculty Publications Publication Book or Journal Article published by New York Tech Facility. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource GEMC1 and MCIDAS interactions with SWI/SNF complexes regulate the multiciliated cell-specific transcriptional program Identifier An unambiguous reference to the resource within a given context https://repository.nyitlibrary.org/files/original/81e730c6a734f4b58cfba5085775b70e.pdf <a href="https://doi.org/10.1038/s41419-023-05720-4">https://doi.org/10.1038/s41419-023-05720-4</a> Creator An entity primarily responsible for making the resource Lewis, M., Terré, B., Knobel, P. A., Cheng, T., Lu, H., Attolini, C. S.-O., Smak, J., Coyaud, E., Garcia-Cao, I., Sharma, S., Vineethakumari, C., Querol, J., Gil-Gómez, G., Piergiovanni, G., Costanzo, V., Peiró, S., Raught, B., Zhao, H., Salvatella, X., Roy, S., Mahjoub M.R., Stracker, T. H. Date A point or period of time associated with an event in the lifecycle of the resource 2023 Subject The topic of the resource Cytology Animals Cell Differentiation Gene Expression Regulation Mammals Nuclear Proteins Nuclear Proteins Language A language of the resource English Abstract A summary of the resource. Multiciliated cells (MCCs) project dozens to hundreds of motile cilia from their apical surface to promote the movement of fluids or gametes in the mammalian brain, airway or reproductive organs. Differentiation of MCCs requires the sequential action of the Geminin family transcriptional activators, GEMC1 and MCIDAS, that both interact with E2F4/5-DP1. How these factors activate transcription and the extent to which they play redundant functions remains poorly understood. Here, we demonstrate that the transcriptional targets and proximal proteomes of GEMC1 and MCIDAS are highly similar. However, we identified distinct interactions with SWI/SNF subcomplexes; GEMC1 interacts primarily with the ARID1A containing BAF complex while MCIDAS interacts primarily with BRD9 containing ncBAF complexes. Treatment with a BRD9 inhibitor impaired MCIDAS-mediated activation of several target genes and compromised the MCC differentiation program in multiple cell based models. Our data suggest that the differential engagement of distinct SWI/SNF subcomplexes by GEMC1 and MCIDAS is required for MCC-specific transcriptional regulation and mediated by their distinct C-terminal domains. Source A related resource from which the described resource is derived <i>Cell Death and Disease</i><span>, Volume 14, Issue 3, March 2023, pages 1-15</span> Rights Information about rights held in and over the resource <b>Open Access</b><span> This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit </span><a href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</a><span>.</span> Format The file format, physical medium, or dimensions of the resource PDF Publisher An entity responsible for making the resource available Springer Science and Business Media LLC Type The nature or genre of the resource Text Bibliographic Citation A bibliographic reference for the resource. Recommended practice is to include sufficient bibliographic detail to identify the resource as unambiguously as possible. <span>Lewis, M., Terré, B., Knobel, P. A., Cheng, T., Lu, H., Attolini, C. S.-O., Smak, J., Coyaud, E., Garcia-Cao, I., Sharma, S., Vineethakumari, C., Querol, J., Gil-Gómez, G., Piergiovanni, G., Costanzo, V., Peiró, S., Raught, B., Zhao, H., Salvatella, X., … Stracker, T. H. (2023). GEMC1 and MCIDAS interactions with SWI/SNF complexes regulate the multiciliated cell-specific transcriptional program. In Cell Death &amp;amp; Disease (Vol. 14, Issue 3). Springer Science and Business Media LLC. <a href="https://doi.org/10.1038/s41419-023-05720-4">https://doi.org/10.1038/s41419-023-05720-4</a></span> AD-293 cell line animal animal experiment animal tissue Animals article cell differentiation cell specificity ciliated epithelium cell controlled study gene expression regulation genetics HEK293T cell line HeLa cell line human human cell mammal Mammals metabolism mouse nonhuman nuclear protein Nuclear Proteins protein protein interaction proteome retinoblastoma binding protein 2 SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily B member 1 transcription regulation https://repository.nyitlibrary.org/files/original/990342b9a4eaa467d246cf41928c75d2.pdf 26d624881a9c0801cfbcab051d447e66 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource NYITCOM - Faculty Publications Publication Book or Journal Article published by New York Tech Facility. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Disruption of GMNC-MCIDAS multiciliogenesis program is critical in choroid plexus carcinoma development Identifier An unambiguous reference to the resource within a given context https://repository.nyitlibrary.org/files/original/990342b9a4eaa467d246cf41928c75d2.pdf <a href="https://doi.org/10.1038/s41418-022-00950-z">https://doi.org/10.1038/s41418-022-00950-z</a> Creator An entity primarily responsible for making the resource Li, Q., Han, Z., Singh, N., Terré, B., Fame, R. M., Arif, U., Page, T. D., Zahran, T., Abdeltawab, A., Huang, Y., Cao, P., Wang, J., Lu, H., Lidov, H. G. W., Surendran, K., Wu, L., Virga, J. Q., Zhao, Y.-T., Schüller, U., Wechsler-Reya, R.J., Lehtinen, M.K., Roy, S., Liu, Z., Stracker, T.H., Zhao, H. Date A point or period of time associated with an event in the lifecycle of the resource 2022 Abstract A summary of the resource. Multiciliated cells (MCCs) in the brain reside in the ependyma and the choroid plexus (CP) epithelia. The CP secretes cerebrospinal fluid that circulates within the ventricular system, driven by ependymal cilia movement. Tumors of the CP are rare primary brain neoplasms mostly found in children. CP tumors exist in three forms: CP papilloma (CPP), atypical CPP, and CP carcinoma (CPC). Though CPP and atypical CPP are generally benign and can be resolved by surgery, CPC is a particularly aggressive and little understood cancer with a poor survival rate and a tendency for recurrence and metastasis. In contrast to MCCs in the CP epithelia, CPCs in humans are characterized by solitary cilia, frequent TP53 mutations, and disturbances to multiciliogenesis program directed by the GMNC-MCIDAS transcriptional network. GMNC and MCIDAS are early transcriptional regulators of MCC fate differentiation in diverse tissues. Consistently, components of the GMNC-MCIDAS transcriptional program are expressed during CP development and required for multiciliation in the CP, while CPC driven by deletion of Trp53 and Rb1 in mice exhibits multiciliation defects consequent to deficiencies in the GMNC-MCIDAS program. Previous studies revealed that abnormal NOTCH pathway activation leads to CPP. Here we show that combined defects in NOTCH and Sonic Hedgehog signaling in mice generates tumors that are similar to CPC in humans. NOTCH-driven CP tumors are monociliated, and disruption of the NOTCH complex restores multiciliation and decreases tumor growth. NOTCH suppresses multiciliation in tumor cells by inhibiting the expression of GMNC and MCIDAS, while Gmnc-Mcidas overexpression rescues multiciliation defects and suppresses tumor cell proliferation. Taken together, these findings indicate that reactivation of the GMNC-MCIDAS multiciliogenesis program is critical for inhibiting tumorigenesis in the CP, and it may have therapeutic implications for the treatment of CPC. Source A related resource from which the described resource is derived <i>Cell Death and Differentiation</i><span>, Volume 29, Issue 8, August 2022, pages 1596-610</span> Language A language of the resource English Rights Information about rights held in and over the resource <b>Open Access</b><span> This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit </span><a href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</a><span>.</span> Format The file format, physical medium, or dimensions of the resource PDF Publisher An entity responsible for making the resource available Springer Science and Business Media LLC Subject The topic of the resource Animals Carcinoma Cell Cycle Proteins Choroid Plexus Neoplasms Hedgehog Proteins / genetics Humans Mice Nuclear Proteins Type The nature or genre of the resource Text Bibliographic Citation A bibliographic reference for the resource. Recommended practice is to include sufficient bibliographic detail to identify the resource as unambiguously as possible. <span>Li, Q., Han, Z., Singh, N., Terré, B., Fame, R. M., Arif, U., Page, T. D., Zahran, T., Abdeltawab, A., Huang, Y., Cao, P., Wang, J., Lu, H., Lidov, H. G. W., Surendran, K., Wu, L., Virga, J. Q., Zhao, Y.-T., Schüller, U., … Zhao, H. (2022). Disruption of GMNC-MCIDAS multiciliogenesis program is critical in choroid plexus carcinoma development. In Cell Death &amp;amp; Differentiation (Vol. 29, Issue 8, pp. 1596–1610). Springer Science and Business Media LLC. <a href="https://doi.org/10.1038/s41418-022-00950-z">https://doi.org/10.1038/s41418-022-00950-z</a></span> animal animal cell Animals article cancer growth cancer therapy carcinogenesis carcinoma cell culture cell cycle protein Cell Cycle Proteins cell disruption cell proliferation child Choroid Plexus Neoplasms choroid plexus tumor ciliated epithelium cell controlled study gene overexpression genetics Hedgehog Proteins hedgehog signaling human human cell Humans immunoblotting immunocytochemistry immunofluorescence immunohistochemistry in situ hybridization Mcidas protein metabolism Mice mouse multi ciliate differentiation and DNA synthesis associated cell cycle protein nonhuman Notch receptor Notch signaling nuclear protein Nuclear Proteins pathology protein expression protein function protein Geminin Coiled Coil Domain Containing protein modification real time polymerase chain reaction signal transduction sonic hedgehog protein tumor cell unclassified drug https://repository.nyitlibrary.org/files/original/0d49a32ca2112ca28ed0bda2ed7a8f85.pdf 2c1a76e2c1a8b75e8ed565de89c04813 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource NYITCOM - Faculty Publications Publication Book or Journal Article published by New York Tech Facility. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Ecomorphological diversification in squamates from conserved pattern of cranial integration Identifier An unambiguous reference to the resource within a given context https://repository.nyitlibrary.org/files/original/0d49a32ca2112ca28ed0bda2ed7a8f85.pdf <a href="https://doi.org/10.1073/pnas.1820967116">https://doi.org/10.1073/pnas.1820967116</a> Creator An entity primarily responsible for making the resource Watanabe, A., Fabre, A.-C., Felice, R. N., Maisano, J. A., Müller, J., Herrel, A., & Goswami, A. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource Animals Biological Evolution Ecosystem Feeding Behavior physiology Fossils anatomy & histology Index Medicus Lizards anatomy & histology physiology Phenotype Phylogeny Skull anatomy & histology physiology Snakes anatomy & histology physiology Squamata Geometric morphometrics Integration and modularity Macroevolution Skull Language A language of the resource English Abstract A summary of the resource. Factors intrinsic and extrinsic to organisms dictate the course of morphological evolution but are seldom considered together in comparative analyses. Among vertebrates, squamates (lizards and snakes) exhibit remarkable morphological and developmental variations that parallel their incredible ecological spectrum. However, this exceptional diversity also makes systematic quantification and analysis of their morphological evolution challenging. We present a squamate-wide, high-density morphometric analysis of the skull across 181 modern and extinct species to identify the primary drivers of their cranial evolution within a unified, quantitative framework. Diet and habitat preferences, but not reproductive mode, are major influences on skull-shape evolution across squamates, with fossorial and aquatic taxa exhibiting convergent and rapid changes in skull shape. In lizards, diet is associated with the shape of the rostrum, reflecting its use in grasping prey, whereas snakes show a correlation between diet and the shape of posterior skull bones important for gape widening. Similarly, we observe the highest rates of evolution and greatest disparity in regions associated with jaw musculature in lizards, whereas those forming the jaw articulation evolve faster in snakes. In addition, high-resolution ancestral cranial reconstructions from these data support a terrestrial, nonfossorial origin for snakes. Despite their disparate evolutionary trends, lizards and snakes unexpectedly share a common pattern of trait integration, with the highest correlations in the occiput, jaw articulation, and palate. We thus demonstrate that highly diverse phenotypes, exemplified by lizards and snakes, can and do arise from differential selection acting on conserved patterns of phenotypic integration. Source A related resource from which the described resource is derived <em>Proceedings of the National Academy of Sciences</em>, Volume 116, Issue 29, June 2019, pages 14688-14697 Format The file format, physical medium, or dimensions of the resource PDF Publisher An entity responsible for making the resource available Proceedings of the National Academy of Sciences Rights Information about rights held in and over the resource Copyright © 2019 the Author(s). Published by PNAS. Type The nature or genre of the resource Text Bibliographic Citation A bibliographic reference for the resource. Recommended practice is to include sufficient bibliographic detail to identify the resource as unambiguously as possible. <span>Watanabe, A., Fabre, A.-C., Felice, R. N., Maisano, J. A., Müller, J., Herrel, A., &amp; Goswami, A. (2019). Ecomorphological diversification in squamates from conserved pattern of cranial integration. In Proceedings of the National Academy of Sciences (Vol. 116, Issue 29, pp. 14688–14697). Proceedings of the National Academy of Sciences. <a href="https://doi.org/10.1073/pnas.1820967116">https://doi.org/10.1073/pnas.1820967116</a></span> anatomy and histology animal animal experiment Animals article Biological Evolution brain diet driver ecosystem evolution extinct species feeding behavior fossil Fossils geometric morphometrics habitat Integration and modularity jaw lizard Lizards Macroevolution morphometry nonhuman palate phenotype Phylogeny physiology quantitative analysis skull snake Snakes snout Squamata https://repository.nyitlibrary.org/files/original/4700f99553d5f68708bd5ee391c8b362.pdf 5596b196ecbefb214e49eee900df865f Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource NYITCOM - Faculty Publications Publication Book or Journal Article published by New York Tech Facility. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource A Practical Guide to Sliding and Surface Semilandmarks in Morphometric Analyses Identifier An unambiguous reference to the resource within a given context https://repository.nyitlibrary.org/files/original/0d49a32ca2112ca28ed0bda2ed7a8f85.pdf <a href="https://doi.org/10.1093/iob/obz016">https://doi.org/10.1093/iob/obz016</a> Creator An entity primarily responsible for making the resource Bardua, C., Felice, R. N., Watanabe, A., Fabre, A.-C., & Goswami, A. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Source A related resource from which the described resource is derived <i>Integrative Organismal Biology</i>, Volume 1, Issue 1, July 2019 Format The file format, physical medium, or dimensions of the resource PDF Language A language of the resource English Abstract A summary of the resource. Advances in imaging technologies, such as computed tomography (CT) and surface scanning, have facilitated the rapid generation of large datasets of high-resolution three-dimensional (3D) specimen reconstructions in recent years. The wealth of phenotypic information available from these datasets has the potential to inform our understanding of morphological variation and evolution. However, the ever-increasing ease of compiling 3D datasets has created an urgent need for sophisticated methods of capturing high-density shape data that reflect the biological complexity in form. Landmarks often do not take full advantage of the rich shape information available from high-resolution 3D specimen reconstructions, as they are typically restricted to sutures or processes that can be reliably identified across specimens and exclude most of the surface morphology. The development of sliding and surface semilandmark techniques has greatly enhanced the quantification of shape, but their application to diverse datasets can be challenging, especially when dealing with the variable absence of some regions within a structure. Using comprehensive 3D datasets of crania that span the entire clades of birds, squamates and caecilians, we demonstrate methods for capturing morphology across incredibly diverse shapes. We detail many of the difficulties associated with applying semilandmarks to comparable regions across highly disparate structures, and provide solutions to some of these challenges, while considering the consequences of decisions one makes in applying these approaches. Finally, we analyze the benefits of high-density sliding semilandmark approaches over landmark-only studies for capturing shape across diverse organisms and discuss the promise of these approaches for the study of organismal form. Rights Information about rights held in and over the resource <div class="copyright copyright-statement">© The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology.</div> <div class="license"> <div class="license-p">This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<a class="link link-uri openInAnotherWindow" href="http://creativecommons.org/licenses/by/4.0/" target="_blank" rel="noreferrer noopener">http://creativecommons.org/licenses/by/4.0/</a>), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.</div> </div> Publisher An entity responsible for making the resource available Oxford University Press Subject The topic of the resource Amphibians / anatomy & histology Anatomic Landmarks / anatomy & histology Animals Biological Evolution Birds / anatomy & histology Models, Anatomic Phenotype Reptiles Skull Type The nature or genre of the resource Text Bibliographic Citation A bibliographic reference for the resource. Recommended practice is to include sufficient bibliographic detail to identify the resource as unambiguously as possible. <span>Bardua, C., Felice, R. N., Watanabe, A., Fabre, A.-C., &amp; Goswami, A. (2019). A Practical Guide to Sliding and Surface Semilandmarks in Morphometric Analyses. In Integrative Organismal Biology (Vol. 1, Issue 1). Oxford University Press (OUP). <a href="https://doi.org/10.1093/iob/obz016">https://doi.org/10.1093/iob/obz016</a></span> https://repository.nyitlibrary.org/files/original/107c11f4a1c5d56910f61d9d6649c628.pdf f74144905c0156a773a4c2248f7bd7f6 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource NYITCOM - Faculty Publications Publication Book or Journal Article published by New York Tech Facility. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource High-Density Morphometric Analysis of Shape and Integration: The Good, the Bad, and the Not-Really-a-Problem Identifier An unambiguous reference to the resource within a given context https://repository.nyitlibrary.org/files/original/107c11f4a1c5d56910f61d9d6649c628.pdf <a href="https://doi.org/10.1093/icb/icz120">https://doi.org/10.1093/icb/icz120</a> Creator An entity primarily responsible for making the resource Goswami, A., Watanabe, A., Felice, R. N., Bardua, C., Fabre, A.-C., & Polly, P. D. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource Amphibians anatomy & histology Anatomic Landmarks anatomy & histology Animals Biological Evolution Birds anatomy & histology Index Medicus Models, Anatomic Phenotype Reptiles anatomy & histology Skull anatomy & histology Language A language of the resource English Abstract A summary of the resource. The field of comparative morphology has entered a new phase with the rapid generation of high-resolution three-dimensional (3D) data. With freely available 3D data of thousands of species, methods for quantifying morphology that harness this rich phenotypic information are quickly emerging. Among these techniques, high-density geometric morphometric approaches provide a powerful and versatile framework to robustly characterize shape and phenotypic integration, the covariances among morphological traits. These methods are particularly useful for analyses of complex structures and across disparate taxa, which may share few landmarks of unambiguous homology. However, high-density geometric morphometrics also brings challenges, for example, with statistical, but not biological, covariances imposed by placement and sliding of semilandmarks and registration methods such as Procrustes superimposition. Here, we present simulations and case studies of high-density datasets for squamates, birds, and caecilians that exemplify the promise and challenges of high-dimensional analyses of phenotypic integration and modularity. We assess: (1) the relative merits of “big” high-density geometric morphometrics data over traditional shape data; (2) the impact of Procrustes superimposition on analyses of integration and modularity; and (3) differences in patterns of integration between analyses using high-density geometric morphometrics and those using discrete landmarks. We demonstrate that for many skull regions, 20–30 landmarks and/or semilandmarks are needed to accurately characterize their shape variation, and landmark-only analyses do a particularly poor job of capturing shape variation in vault and rostrum bones. Procrustes superimposition can mask modularity, especially when landmarks covary in parallel directions, but this effect decreases with more biologically complex covariance patterns. The directional effect of landmark variation on the position of the centroid affects recovery of covariance patterns more than landmark number does. Landmark-only and landmark-plus-sliding-semilandmark analyses of integration are generally congruent in overall pattern of integration, but landmark-only analyses tend to show higher integration between adjacent bones, especially when landmarks placed on the sutures between bones introduces a boundary bias. Allometry may be a stronger influence on patterns of integration in landmark-only analyses, which show stronger integration prior to removal of allometric effects compared to analyses including semilandmarks. High-density geometric morphometrics has its challenges and drawbacks, but our analyses of simulated and empirical datasets demonstrate that these potential issues are unlikely to obscure genuine biological signal. Rather, high-density geometric morphometric data exceed traditional landmark-based methods in characterization of morphology and allow more nuanced comparisons across disparate taxa. Combined with the rapid increases in 3D data availability, high-density morphometric approaches have immense potential to propel a new class of studies of comparative morphology and phenotypic integration. Source A related resource from which the described resource is derived <i>Integrative and Comparative Biology</i>, Volume 11, Issue 7,<span> 2019, pages 669–683</span> Rights Information about rights held in and over the resource <div class="line-container"> <div class="line-element PageTitleCell"> <p class="PageTitle">Creative Commons</p> </div> </div> <div class="line-container"> <div class="line-element MainInstructionsCell"> <p class="MainInstructions">This is an open-access article distributed under the terms of the<span> </span><a href="https://creativecommons.org/licenses/" target="_blank" rel="noreferrer noopener">Creative Commons CC BY</a><span> </span>license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.<br /><br />You are not required to obtain permission to reuse this article.</p> </div> </div> Format The file format, physical medium, or dimensions of the resource PDF Publisher An entity responsible for making the resource available Oxford University Press Bibliographic Citation A bibliographic reference for the resource. Recommended practice is to include sufficient bibliographic detail to identify the resource as unambiguously as possible. <span>Goswami, A., Watanabe, A., Felice, R. N., Bardua, C., Fabre, A.-C., &amp; Polly, P. D. (2019). High-Density Morphometric Analysis of Shape and Integration: The Good, the Bad, and the Not-Really-a-Problem. In Integrative and Comparative Biology (Vol. 59, Issue 3, pp. 669–683). Oxford University Press (OUP). <a href="https://doi.org/10.1093/icb/icz120">https://doi.org/10.1093/icb/icz120</a></span> Amphibia Amphibians Anatomic anatomic landmark Anatomic Landmarks anatomic model anatomy and histology animal Animals Biological Evolution bird Birds evolution Models phenotype reptile Reptiles skull https://repository.nyitlibrary.org/files/original/56c2fc1085f9d075656bb58d8d6a497c.pdf c5cd14786a40d749eb2d99915348a414 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource NYITCOM - Faculty Publications Publication Book or Journal Article published by New York Tech Facility. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The Effects of Genetic and Epigenetic Alterations of BARD1 on the Development of Non-Breast and Non-Gynecological Cancers Identifier An unambiguous reference to the resource within a given context https://repository.nyitlibrary.org/files/original/56c2fc1085f9d075656bb58d8d6a497c.pdf <a href="https://doi.org/10.3390/genes11070829">https://doi.org/10.3390/genes11070829</a> Creator An entity primarily responsible for making the resource Watters, A. K., Seltzer, E. S., MacKenzie, D., Jr., Young, M., Muratori, J., Hussein, R., Sodoma, A. M., To, J., Singh, M., & Zhang, D. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource BARD1 BARD1 isoforms BRCA1 Protein genetics Central Nervous System Neoplasms genetics Epigenesis, Genetic Gastrointestinal Neoplasms genetics Humans Index Medicus Lung Neoplasms genetics Mutation Tumor Suppressor Proteins genetics Ubiquitin-Protein Ligases genetics cancers Single nucleotide polymorphism (SNP) Language A language of the resource English Abstract A summary of the resource. Breast Cancer 1 (BRCA1) gene is a well-characterized tumor suppressor gene, mutations of which are primarily found in women with breast and ovarian cancers. BRCA1-associated RING domain 1 (BARD1) gene has also been identified as an important tumor suppressor gene in breast, ovarian, and uterine cancers. Underscoring the functional significance of the BRCA1 and BARD1 interactions, prevalent mutations in the BRCA1 gene are found in its RING domain, through which it binds the RING domain of BARD1. BARD1-BRCA1 heterodimer plays a crucial role in a variety of DNA damage response (DDR) pathways, including DNA damage checkpoint and homologous recombination (HR). However, many mutations in both BARD1 and BRCA1 also exist in other domains that significantly affect their biological functions. Intriguingly, recent genome-wide studies have identified various single nucleotide polymorphisms (SNPs), genetic alterations, and epigenetic modifications in or near the BARD1 gene that manifested profound effects on tumorigenesis in a variety of non-breast and non-gynecological cancers. In this review, we will briefly discuss the molecular functions of BARD1, including its BRCA1-dependent as well as BRCA1-independent functions. We will then focus on evaluating the common BARD1 related SNPs as well as genetic and epigenetic changes that occur in the non-BRCA1-dominant cancers, including neuroblastoma, lung, and gastrointestinal cancers. Furthermore, the pro- and anti-tumorigenic functions of different SNPs and BARD1 variants will also be discussed. Source A related resource from which the described resource is derived <em>Genes</em>, Volume 11, Issue 7, July 2020, pages 829 Rights Information about rights held in and over the resource <span>© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (</span><a href="http://creativecommons.org/licenses/by/4.0/" target="_blank" rel="noreferrer noopener">http://creativecommons.org/licenses/by/4.0/</a><span>).</span> Format The file format, physical medium, or dimensions of the resource PDF Publisher An entity responsible for making the resource available MDPI AG Bibliographic Citation A bibliographic reference for the resource. Recommended practice is to include sufficient bibliographic detail to identify the resource as unambiguously as possible. <span>Watters, A. K., Seltzer, E. S., MacKenzie, D., Jr., Young, M., Muratori, J., Hussein, R., Sodoma, A. M., To, J., Singh, M., &amp; Zhang, D. (2020). The Effects of Genetic and Epigenetic Alterations of BARD1 on the Development of Non-Breast and Non-Gynecological Cancers. In Genes (Vol. 11, Issue 7, p. 829). MDPI AG. <a href="https://doi.org/10.3390/genes11070829">https://doi.org/10.3390/genes11070829</a></span> apoptosis BARD1 Bard1 gene BARD1 isoforms BARD1 protein BRCA1 associated ring domain protein 1 BRCA1 protein breast cancer Cancers carcinogenesis cell cycle regulation Central Nervous System Neoplasms central nervous system tumor digestive system cancer DNA DNA damage checkpoint DNA damage response DNA modification Epigenesis epigenetics esophageal squamous cell carcinoma Ewing sarcoma Gastrointestinal Neoplasms gastrointestinal tumor gene function gene mutation Genetic genetic epigenesis genetic variability genetics genome-wide association study heterodimer homologous recombination human Humans immunoglobulin enhancer binding protein leukemia liver cell carcinoma lung cancer Lung Neoplasms lung tumor mutation nephroblastoma neuroblastoma nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase non small cell lung cancer ovary cancer pancreas cancer prevalence protein binding protein domain protein p53 Review single nucleotide polymorphism Single nucleotide polymorphism (SNP) tumor suppressor gene tumor suppressor protein Tumor Suppressor Proteins ubiquitin protein ligase Ubiquitin-Protein Ligases https://repository.nyitlibrary.org/files/original/101294cb0cc2e3b2d54baa4d3639bee7.pdf 0b9cf2610f9ecdb53ebada3e6b1c5589 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource NYITCOM - Faculty Publications Publication Book or Journal Article published by New York Tech Facility. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Physiological and Cognitive Functions Following a Discrete Session of Competitive Esports Gaming Identifier An unambiguous reference to the resource within a given context https://repository.nyitlibrary.org/files/original/101294cb0cc2e3b2d54baa4d3639bee7.pdf <a href="https://doi.org/10.3389/fpsyg.2020.01030"><span>https://doi.org/10.3389/fpsyg.2020.01030</span></a> Creator An entity primarily responsible for making the resource Sousa, A., Ahmad, S. L., Hassan, T., Yuen, K., Douris, P., Zwibel, H., & DiFrancisco-Donoghue, J. Subject The topic of the resource Psychology Cognition Competitive gaming eSports Executive functions Health Language A language of the resource English Abstract A summary of the resource. Competitive organized electronic video gaming, termed “esports,” has become an international industry. The physiological and cognitive health results of prolonged esport practice and competition have not been adequately studied. The current study examined physiological and cognitive changes after a session of esport gameplay for two types of games, first-person shooter and multiplayer online battle arena games. Increases in systolic blood pressure, increases in speed, and decreases in accuracy and inhibitory processes were found for esport gamers overall. For peak heart rate change, first-person shooter games elicited a larger change than did multiplayer online battle arena games. These results have implications for the management of esport player cognitive and physical health as well as for the optimization of performance in competitive esport tournaments. Rights Information about rights held in and over the resource <span>Copyright</span><span> © 2020 Sousa, Ahmad, Hassan, Yuen, Douris, Zwibel and DiFrancisco-Donoghue. This is an open-access article distributed under the terms of the </span><a href="http://creativecommons.org/licenses/by/4.0/" target="_blank" rel="noreferrer noopener">Creative Commons Attribution License (CC BY)</a><span>. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</span> Source A related resource from which the described resource is derived <i>Frontiers in Psychology</i>, Volume 11, May <span>2020 pages 1030–1030</span> Format The file format, physical medium, or dimensions of the resource PDF Date A point or period of time associated with an event in the lifecycle of the resource 2020 Type The nature or genre of the resource Text Bibliographic Citation A bibliographic reference for the resource. Recommended practice is to include sufficient bibliographic detail to identify the resource as unambiguously as possible. <span>Sousa, A., Ahmad, S. L., Hassan, T., Yuen, K., Douris, P., Zwibel, H., &amp; DiFrancisco-Donoghue, J. (2020). Physiological and Cognitive Functions Following a Discrete Session of Competitive Esports Gaming. In Frontiers in Psychology (Vol. 11). Frontiers Media SA. <a href="https://doi.org/10.3389/fpsyg.2020.01030">https://doi.org/10.3389/fpsyg.2020.01030</a></span> Publisher An entity responsible for making the resource available Frontiers Media SA cognition competitive gaming esports executive functions Health https://repository.nyitlibrary.org/files/original/b384a437fa6fae8281b28cef4cacf189.pdf 9789a9f272ff39214ac86906fd8df02d Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource NYITCOM - Faculty Publications Publication Book or Journal Article published by New York Tech Facility. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Editorial: Mechanisms and Therapy for Cancer Metastasis to the Central Nervous System Identifier An unambiguous reference to the resource within a given context https://repository.nyitlibrary.org/files/original/b384a437fa6fae8281b28cef4cacf189.pdf <a href="https://doi.org/10.3389/fonc.2019.00064">https://doi.org/10.3389/fonc.2019.00064</a> Format The file format, physical medium, or dimensions of the resource PDF Creator An entity primarily responsible for making the resource Zhao, H., & Eisenstat, D. D. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource Brain metastases Cerebrospinal fluid - CSF Driver mutation Macrophage microglia activation Reactive astrocyte Xenografts model Language A language of the resource English Source A related resource from which the described resource is derived <em>Neuro-Oncology and Neurosurgical</em> <em>Oncology</em>, <span class="volumeInfo">Volume 9, February 2019</span> Rights Information about rights held in and over the resource <span>Copyright</span><span> © 2019 Zhao and Eisenstat. This is an open-access article distributed under the terms of the </span><a href="http://creativecommons.org/licenses/by/4.0/" target="_blank" rel="noreferrer noopener">Creative Commons Attribution License (CC BY)</a><span>. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</span> Publisher An entity responsible for making the resource available Frontiers Media SA Type The nature or genre of the resource Text Bibliographic Citation A bibliographic reference for the resource. Recommended practice is to include sufficient bibliographic detail to identify the resource as unambiguously as possible. <span>Zhao, H., &amp; Eisenstat, D. D. (2019). Editorial: Mechanisms and Therapy for Cancer Metastasis to the Central Nervous System. In Frontiers in Oncology (Vol. 9). Frontiers Media SA. <a href="https://doi.org/10.3389/fonc.2019.00064">https://doi.org/10.3389/fonc.2019.00064</a></span> angiogenesis antiinflammatory activity astrocyte brain metastasis breast cancer carcinomatous meningitis central nervous system metastasis cerebrospinal fluid analysis circulating tumor DNA follow up gene expression profiling gene mutation genetic profile human immune response immunotherapy macrophage malignant neoplasm microglia nonhuman nuclear magnetic resonance imaging positron emission tomography-computed tomography Review treatment planning treatment response tumor growth tumor microenvironment upregulation https://repository.nyitlibrary.org/files/original/7020ba3f008327562c521609ef027895.pdf 204e954bffc8fa47d954c965aeac32e5 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource NYITCOM - Faculty Publications Publication Book or Journal Article published by New York Tech Facility. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Targeting the BRCA1/2 Deficient Cancer With Parp Inhibitors: Clinical Outcomes and Mechanistic Insights Identifier An unambiguous reference to the resource within a given context https://repository.nyitlibrary.org/files/original/7020ba3f008327562c521609ef027895.pdf <a href="https://doi.org/10.3389/fcell.2023.1133472">https://doi.org/10.3389/fcell.2023.1133472</a> Creator An entity primarily responsible for making the resource Ragupathi, A., Singh, M., Perez, A. M., & Zhang, D. Date A point or period of time associated with an event in the lifecycle of the resource 2023 Subject The topic of the resource BRCA1 and BRCA2 Biology (General) PARP inhibitors PARP1 Breast cancer Ovarian cancer Synthetic lethality Language A language of the resource English Abstract A summary of the resource. BRCA1 and BRCA2 play a critical role in a variety of molecular processes related to DNA metabolism, including homologous recombination and mediating the replication stress response. Individuals with mutations in the BRCA1 and BRCA2 (BRCA1/2) genes have a significantly higher risk of developing various types of cancers, especially cancers of the breast, ovary, pancreas, and prostate. Currently, the Food and Drug Administration (FDA) has approved four PARP inhibitors (PARPi) to treat cancers with BRCA1/2 mutations. In this review, we will first summarize the clinical outcomes of the four FDA-approved PARPi in treating BRCA1/2 deficient cancers. We will then discuss evidence supporting the hypothesis that the cytotoxic effect of PARPi is likely due to inducing excessive replication stress at the difficult-to-replicate (DTR) genomic regions in BRCA1/2 mutated tumors. Finally, we will discuss the ongoing preclinical and clinical studies on how to combine the PARPi with immuno-oncology drugs to further improve clinical outcomes. Source A related resource from which the described resource is derived <i>Frontiers in Cell and Developmental Biology</i>, Volume 11, March <span>2023, pages 1133472–1133472</span> Rights Information about rights held in and over the resource <span>Copyright</span><span> © 2023 Ragupathi, Singh, Perez and Zhang. This is an open-access article distributed under the terms of the </span><a href="http://creativecommons.org/licenses/by/4.0/" target="_blank" rel="noreferrer noopener">Creative Commons Attribution License (CC BY).</a><span> The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</span> Format The file format, physical medium, or dimensions of the resource PDF Publisher An entity responsible for making the resource available Frontiers Medicine SA Type The nature or genre of the resource Text Bibliographic Citation A bibliographic reference for the resource. Recommended practice is to include sufficient bibliographic detail to identify the resource as unambiguously as possible. <span>Ragupathi, A., Singh, M., Perez, A. M., &amp; Zhang, D. (2023). Targeting the BRCA1/2 deficient cancer with PARP inhibitors: Clinical outcomes and mechanistic insights. In Frontiers in Cell and Developmental Biology (Vol. 11). Frontiers Media SA. <a href="https://doi.org/10.3389/fcell.2023.1133472">https://doi.org/10.3389/fcell.2023.1133472</a></span> https://repository.nyitlibrary.org/files/original/fa70671c034ef171c53a65721fb77a01.pdf 47dea2f6b7fc0e91dc85e6c1dbb0e196 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource NYITCOM - Faculty Publications Publication Book or Journal Article published by New York Tech Facility. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Managing the health of the eSport athlete: an integrated health management model Identifier An unambiguous reference to the resource within a given context https://repository.nyitlibrary.org/files/original/fa70671c034ef171c53a65721fb77a01.pdf <a href="https://doi.org/10.1136/bmjsem-2018-000467">https://doi.org/10.1136/bmjsem-2018-000467</a> Creator An entity primarily responsible for making the resource DiFrancisco-Donoghue, J., Balentine, J., Schmidt, G., & Zwibel, H. Subject The topic of the resource Exercise rehabilitation Overuse Sports & exercise medicine Sports medicine Language A language of the resource English Abstract A summary of the resource. <div class="subsection"> <p><strong>Objectives</strong><span> </span>eSport is a form of electronic gaming, also known as professional or competitive video gaming, and is growing at a rapid pace worldwide. Over 50 US colleges have established varsity gaming teams over the past three years; some colleges offer eSport scholarships as they do for traditional sports. There is little objective research on the health habits of these players who are often placed under the direction of the athletics department on college campuses, and there is currently no health management model on how to treat these new athletes.</p> </div> <div class="subsection"> <p><strong>Methods</strong><span> </span>Anonymous electronic surveys were sent to 65 collegiate eSport players from nine universities across the USA and Canada inquiring about gaming and lifestyle habits, and musculoskeletal complaints due to eSport competition.</p> </div> <div class="subsection"> <p><strong>Results</strong><span> </span>Players practiced between 3 and 10 hours per day. The most frequently reported complaint was eye fatigue (56%), followed by neck and back pain (42%). eSport athletes reported wrist pain (36%) and hand pain (32%). Forty per cent of participants do not participate in any form of physical exercise. Among the players surveyed, only 2% had sought medical attention.</p> </div> <div class="subsection"> <p><strong>Conclusion</strong><span> </span>eSport players, just like athletes in traditional sports, are susceptible to overuse injuries. The most common complaint was eye fatigue, followed by neck and back pain. This study shows eSport athletes are also prone to wrist and hand pain. This paper proposes a health management model that offers a comprehensive medical team approach to prevent and treat eSport athletes.</p> </div> Source A related resource from which the described resource is derived <i>BMJ Open Sport &amp; Exercise Medicine</i>, Volume 5, Issue 1, January <span>2019, pages e000467–e000467</span> Rights Information about rights held in and over the resource <span>This is an open-access article distributed in accordance with the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: </span><a href="http://creativecommons.org/licenses/by-nc/4.0/">http://creativecommons.org/licenses/by-nc/4.0/</a><span>.</span> Format The file format, physical medium, or dimensions of the resource PDF Date A point or period of time associated with an event in the lifecycle of the resource 2019 Publisher An entity responsible for making the resource available BMJ Type The nature or genre of the resource Text Bibliographic Citation A bibliographic reference for the resource. Recommended practice is to include sufficient bibliographic detail to identify the resource as unambiguously as possible. <span>DiFrancisco-Donoghue, J., Balentine, J., Schmidt, G., &amp; Zwibel, H. (2019). Managing the health of the eSport athlete: an integrated health management model. In BMJ Open Sport &amp;amp; Exercise Medicine (Vol. 5, Issue 1, p. e000467). BMJ. <a href="https://doi.org/10.1136/bmjsem-2018-000467">https://doi.org/10.1136/bmjsem-2018-000467</a></span> https://repository.nyitlibrary.org/files/original/45fb0fa9261ac518b5a1a88b1977f092.pdf 43a0a1995cc615110f9b928e21f7ba63 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource NYITCOM - Faculty Publications Publication Book or Journal Article published by New York Tech Facility. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource ALT Positivity in Human Cancers: Prevalence and Clinical Insights Identifier An unambiguous reference to the resource within a given context https://repository.nyitlibrary.org/files/original/45fb0fa9261ac518b5a1a88b1977f092.pdf <a href="https://doi.org/10.3390/cancers13102384">https://doi.org/10.3390/cancers13102384</a> Creator An entity primarily responsible for making the resource MacKenzie, D., Jr., Watters, A. K., To, J. T., Young, M. W., Muratori, J., Wilkoff, M. H., Abraham, R. G., Plummer, M. M., & Zhang, D. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Publisher An entity responsible for making the resource available MDPI AG Subject The topic of the resource Alternative lengthening of telomeres Cancers ALT biomarkers ATRX DAXX Language A language of the resource English Abstract A summary of the resource. <span>Many exciting advances in cancer-related telomere biology have been made in the past decade. Of these recent advances, great progress has also been made with respect to the Alternative Lengthening of Telomeres (ALT) pathway. Along with a better understanding of the molecular mechanism of this unique telomere maintenance pathway, many studies have also evaluated ALT activity in various cancer subtypes. We first briefly review and assess a variety of commonly used ALT biomarkers. Then, we provide both an update on ALT-positive (ALT+) tumor prevalence as well as a systematic clinical assessment of the presently studied ALT+ malignancies. Additionally, we discuss the pathogenetic alterations in ALT+ cancers, for example, the mutation status of </span><span class="html-italic">ATRX</span><span> and </span><span class="html-italic">DAXX</span><span>, and their correlations with the activation of the ALT pathway. Finally, we highlight important ALT+ clinical associations within each cancer subtype and subdivisions within, as well as their prognoses. We hope this alternative perspective will allow scientists, clinicians, and drug developers to have greater insight into the ALT cancers so that together, we may develop more efficacious treatments and improved management strategies to meet the urgent needs of cancer patients.</span> Source A related resource from which the described resource is derived <em>Cancers</em>, Volume 13, Issue 10, May 2021, Page 2384 Rights Information about rights held in and over the resource <span>All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited.</span> Format The file format, physical medium, or dimensions of the resource PDF Type The nature or genre of the resource Text Bibliographic Citation A bibliographic reference for the resource. Recommended practice is to include sufficient bibliographic detail to identify the resource as unambiguously as possible. <span>MacKenzie, D., Jr., Watters, A. K., To, J. T., Young, M. W., Muratori, J., Wilkoff, M. H., Abraham, R. G., Plummer, M. M., &amp; Zhang, D. (2021). ALT Positivity in Human Cancers: Prevalence and Clinical Insights. In Cancers (Vol. 13, Issue 10, p. 2384). MDPI AG. <a href="https://doi.org/10.3390/cancers13102384">https://doi.org/10.3390/cancers13102384</a></span> ALT biomarkers alternative lengthening of telomeres ATRX cancer DAXX https://repository.nyitlibrary.org/files/original/14d9cdb896c7e10dfb1a7589eae93b7e.pdf 648a34a3fd5f8d4ba5800b55a72f5ab5 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource NYITCOM - Faculty Publications Publication Book or Journal Article published by New York Tech Facility. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Computational Biology: A New Frontier in Applied Biology Identifier An unambiguous reference to the resource within a given context https://repository.nyitlibrary.org/files/original/45fb0fa9261ac518b5a1a88b1977f092.pdf <a href="https://doi.org/10.3390/biology10050374">https://doi.org/10.3390/biology10050374</a> <a href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</a> Source A related resource from which the described resource is derived <em>Biology </em>Volume 10, Issue 5, April 2021, page 374 Rights Information about rights held in and over the resource <div class="fm-copyright half_rhythm"> <div class="fm-copyright half_rhythm"><a href="https://www.ncbi.nlm.nih.gov/pmc/about/copyright/">Copyright</a><span> </span>© 2021 by the authors.</div> <div class="license half_rhythm">Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (<a href="https://creativecommons.org/licenses/by/4.0/" target="_blank" rel="noreferrer noopener">https://creativecommons.org/licenses/by/4.0/</a>).</div> </div> Format The file format, physical medium, or dimensions of the resource PDF Type The nature or genre of the resource Text Bibliographic Citation A bibliographic reference for the resource. Recommended practice is to include sufficient bibliographic detail to identify the resource as unambiguously as possible. <span>MacKenzie, D., Jr., Watters, A. K., To, J. T., Young, M. W., Muratori, J., Wilkoff, M. H., Abraham, R. G., Plummer, M. M., &amp; Zhang, D. (2021). ALT Positivity in Human Cancers: Prevalence and Clinical Insights. In Cancers (Vol. 13, Issue 10, p. 2384). MDPI AG. <a href="https://doi.org/10.3390/cancers13102384">https://doi.org/10.3390/cancers13102384</a></span> Creator An entity primarily responsible for making the resource Toma, M., & Concu, R. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Publisher An entity responsible for making the resource available MDPI AG Language A language of the resource English Subject The topic of the resource Computational Biology Computational techniques https://repository.nyitlibrary.org/files/original/c06c760899d29021dba643f5f575106f.pdf a90bb65b74f423074b144a9c7ca8dc86 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource NYITCOM - Faculty Publications Publication Book or Journal Article published by New York Tech Facility. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Insulin and Igf-1 Elicit Robust Transcriptional Regulation to Modulate Autophagy in Astrocytes Identifier An unambiguous reference to the resource within a given context <a href="https://repository.nyitlibrary.org/files/original/c06c760899d29021dba643f5f575106f.pdf">https://repository.nyitlibrary.org/files/original/c06c760899d29021dba643f5f575106f.pdf</a> <a href="https://doi.org/10.1016/j.molmet.2022.101647">https://doi.org/10.1016/j.molmet.2022.101647</a> Creator An entity primarily responsible for making the resource Geffken, S. J., Moon, S., Smith, C. O., Tang, S., Lee, H. H., Lewis, K., Wong, C. W., Huang, Y., Huang, Q., Zhao, Y.-T., & Cai, W. Date A point or period of time associated with an event in the lifecycle of the resource 2022 Publisher An entity responsible for making the resource available Elsevier BV Subject The topic of the resource Insuling IGF-1 Astrocytes Transcription Autophagy Proteostasis Language A language of the resource English Abstract A summary of the resource. <h4>Objective</h4> <p>Insulin is a principal metabolic hormone. It regulates a plethora of metabolic pathways in peripheral tissues. The highly homologous insulin-like growth factor 1 (IGF-1), on the other hand, is important for development and growth. Recent studies have shown that insulin and IGF-1 signaling plays fundamental roles in the brain. Loss of insulin or IGF-1 receptors in astrocytes leads to altered glucose handling, mitochondrial metabolism, neurovascular coupling, and behavioral abnormalities in mice. Here, we aim to investigate molecular mechanisms by which insulin and IGF-1 signaling regulates astrocyte functions.</p> <h4>Methods</h4> <p>IR-flox and IRKO primary astrocytes were treated with 100 nM insulin or IGF-1 for 6 h, and their transcriptomes were analyzed. Astrocytes with either IR deletion, IGF1R deletion or both were used to examine receptor-dependent transcriptional regulations using qPCR. Additional immunoblotting and confocal imaging studies were performed to functionally validate pathways involved in protein homeostasis.</p> <h4>Results</h4> <p>Using next-generation RNA sequencing, we show that insulin significantly regulates the expression of over 1,200 genes involved in multiple functional processes in primary astrocytes. Insulin-like growth factor 1 (IGF-1) triggers a similar robust transcriptional regulation in astrocytes. Thus, over 50% of the differentially expressed genes are regulated by both ligands. As expected, these commonly regulated genes are highly enriched in pathways involved in lipid and cholesterol biosynthesis. Additionally, insulin and IGF-1 induce the expression of genes involved in ribosomal biogenesis, while suppressing the expression of genes involved in autophagy, indicating a common role of insulin and IGF-1 on protein homeostasis in astrocytes. Insulin-dependent suppression of autophagy genes, including<span> </span><i>p62</i><span> </span>,<span> </span><i>Ulk1/2</i><span> </span>, and several<span> </span><i>Atg</i><span> </span>genes, is blunted only when both IR and IGF1R are deleted.</p> <h4>Conclusions</h4> <p>In summary, insulin and IGF-1 potently suppress autophagy in astrocytes through transcriptional regulation. Both IR and IGF1R can elicit ligand-dependent transcriptional suppression of autophagy. These results demonstrate an important role of astrocytic insulin/IGF-1 signaling on proteostasis. Impairment of this regulation in insulin resistance and diabetes may contribute to neurological complications related to diabetes.</p> Source A related resource from which the described resource is derived <em>Molecular Metabolism</em> Volume 66, December 2022, page 101647 Rights Information about rights held in and over the resource Copyright © 2022 The Authors Format The file format, physical medium, or dimensions of the resource PDF Type The nature or genre of the resource Text Bibliographic Citation A bibliographic reference for the resource. Recommended practice is to include sufficient bibliographic detail to identify the resource as unambiguously as possible. <span>Geffken, S. J., Moon, S., Smith, C. O., Tang, S., Lee, H. H., Lewis, K., Wong, C. W., Huang, Y., Huang, Q., Zhao, Y.-T., &amp; Cai, W. (2022). Insulin and IGF-1 elicit robust transcriptional regulation to modulate autophagy in astrocytes. In Molecular Metabolism (Vol. 66, p. 101647). Elsevier BV. <a href="https://doi.org/10.1016/j.molmet.2022.101647">https://doi.org/10.1016/j.molmet.2022.101647</a></span> astrocytes autophagy igf-1 insulin proteostasis transcription https://repository.nyitlibrary.org/files/original/d6435b99ba57cdb5c696e6393100c27d.pdf df74526723094e68f12d8ff5caaa913a Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource NYITCOM - Faculty Publications Publication Book or Journal Article published by New York Tech Facility. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Utilizing Wearable Technology to Increase Physical Activity in Future Physicians: A Randomized Trial Identifier An unambiguous reference to the resource within a given context https://repository.nyitlibrary.org/files/original/d6435b99ba57cdb5c696e6393100c27d.pdf <a href="https://doi.org/10.1016/j.pmedr.2018.09.004"><span>https://doi.org/10.1016/j.pmedr.2018.09.004</span></a> <a href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</a> Creator An entity primarily responsible for making the resource DiFrancisco-Donoghue, J., Jung, M.-K., Stangle, A., Werner, W. G., Zwibel, H., Happel, P., & Balentine, J. Date A point or period of time associated with an event in the lifecycle of the resource 2018 Publisher An entity responsible for making the resource available Elsevier BV Subject The topic of the resource Fitbit Exercise Medicine Obesity Body composition Language A language of the resource English Abstract A summary of the resource. <span>This study examined the use of activity trackers alone or combined with weekly communication through email to improve activity and body composition over one academic year in <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/medical-student" title="Learn more about medical students from ScienceDirect's AI-generated Topic Pages" class="topic-link">medical students</a>. This </span><a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/randomized-clinical-trial" title="Learn more about randomized clinical trial from ScienceDirect's AI-generated Topic Pages" class="topic-link">randomized clinical trial</a><span> conducted at the New York Institute of Technology from July 7, 2016 through June 4, 2017 enrolled 120 medical students. The first group (Fitbit-Plus) wore activity trackers and received weekly emails offering fitness challenges and lifestyle modification challenges. The second group (Fitbit-Only) received only activity trackers and did not receive weekly emails. The third group (Control) was asked not to purchase an activity tracker of any kind throughout the study. All groups had a body composition analysis prior to the start of the academic year and at the end of the first academic year. Outcome measures included step count and body composition (body fat percentage and lean body mass). The results showed the overall mean daily steps were greater in the Fitbit-Plus group than the Fitbit-Only group for the academic year (7429 ± 2833 vs. 6483 ± 2359) with only months April and May showing a significant difference between the groups (p = 0.011; p = 0.044). Body fat percentage decreased in the Fitbit-Plus overweight women (2.1 ± 1.6%) <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/lean-body-weight" title="Learn more about lean body mass from ScienceDirect's AI-generated Topic Pages" class="topic-link">lean body mass</a> increased in the Fitbit-Plus group in overweight men (2.4 ± 4.6 lbs.). A subsequent finding of this study showed improved body composition in a small sub-group of over-weight students. Weekly behavioral challenges combined with an activity tracker increased step count in medical students compared to an activity tracker alone.</span> Source A related resource from which the described resource is derived <em>Preventive Medicine Reports </em>Volume 12, December 2018, pages 122-127 Rights Information about rights held in and over the resource <span>This is an open access article distributed under the terms of the </span><a href="http://creativecommons.org/licenses/by/4.0/" target="_blank" rel="noreferrer noopener">Creative Commons CC-BY</a><span> license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</span> Format The file format, physical medium, or dimensions of the resource PDF Type The nature or genre of the resource Text Bibliographic Citation A bibliographic reference for the resource. Recommended practice is to include sufficient bibliographic detail to identify the resource as unambiguously as possible. <span>DiFrancisco-Donoghue, J., Jung, M.-K., Stangle, A., Werner, W. G., Zwibel, H., Happel, P., &amp; Balentine, J. (2018). Utilizing wearable technology to increase physical activity in future physicians: A randomized trial. In Preventive Medicine Reports (Vol. 12, pp. 122–127). Elsevier BV. <a href="https://doi.org/10.1016/j.pmedr.2018.09.004">https://doi.org/10.1016/j.pmedr.2018.09.004</a></span> body composition exercise fitbit medicine obesity https://repository.nyitlibrary.org/files/original/662bc0d533a7148864cc8eaaea6ed2d1.pdf 2cf8db665ba1aee6052af8ff0b9d365e Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource NYITCOM - Faculty Publications Publication Book or Journal Article published by New York Tech Facility. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Esports Players, Got Muscle? Competitive Video Game Players’ Physical Activity, Body Fat, Bone Mineral Content, and Muscle Mass in Comparison to Matched Controls Identifier An unambiguous reference to the resource within a given context https://repository.nyitlibrary.org/files/original/c06c760899d29021dba643f5f575106f.pdf <a href="https://doi.org/10.1016/j.jshs.2020.07.006">https://doi.org/10.1016/j.jshs.2020.07.006</a> <a href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</a> Creator An entity primarily responsible for making the resource DiFrancisco-Donoghue, J., Werner, W. G., Douris, P. C., & Zwibel, H. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Publisher An entity responsible for making the resource available Elsevier BV Subject The topic of the resource Body composition Body mass index Gaming Language A language of the resource English Abstract A summary of the resource. <p><strong class="sub-title">Background:<span> </span></strong>Esports players, like traditional athletes, practice for long hours and, thus, are vulnerable to the negative health effects of prolonged sitting. There is a lack of research on the physical activity and the health ramifications of prolonged sitting by competitive players. The purpose of this study was to investigate activity levels, body mass index (BMI), and body composition in collegiate esports players as compared to age-matched controls.</p> <p><strong class="sub-title">Methods:<span> </span></strong>Twenty-four male collegiate esports players and non-esports players between 18 and 25 years of age signed a written consent to participate. Physical activity was examined using daily activity (step count) with a wrist-worn activity tracker. A questionnaire assessing physical activity was also administered. Secondary outcomes included body-fat percentage, lean-body mass, BMI, and bone mineral content measured using dual X-ray absorptiometry.</p> <p><strong class="sub-title">Results:<span> </span></strong>The step count in the esports players was significantly lower than the age-matched controls (6040.2 ± 3028.6 vs. 12843.8 ± 5661.1; p = 0.004). Esports players exhibited greater body-fat percentage (p = 0.05), less lean body mass (p = 0.003), and less bone mineral content (p = 0.03), despite no difference in BMI between the esports and non-esports players.</p> <p><strong class="sub-title">Conclusion:<span> </span></strong>As compared to non-esports players, collegiate esports players were significantly less active and had a higher body-fat percentage, with lower lean body mass and bone mineral content. The BMIs showed no difference between the 2 groups. Esports athletes displayed significantly less activity and poor body composition, which are all correlated with potential health issues and risk of injury. BMI did not capture this difference and should not be considered as an accurate measure of health in competitive esports players.</p> Source A related resource from which the described resource is derived <em>Journal of Sport and Health Science </em>Volume 11, Issue 6, November 2022, pages 725-730 Rights Information about rights held in and over the resource <span>This article is available under the </span><a target="_blank" href="https://creativecommons.org/licenses/" rel="noreferrer noopener">Creative Commons CC-BY-NC-ND</a><span> license and permits non-commercial use of the work as published, without adaptation or alteration provided the work is fully attributed.</span> Format The file format, physical medium, or dimensions of the resource PDF Type The nature or genre of the resource Text Bibliographic Citation A bibliographic reference for the resource. Recommended practice is to include sufficient bibliographic detail to identify the resource as unambiguously as possible. <span>DiFrancisco-Donoghue, J., Werner, W. G., Douris, P. C., &amp; Zwibel, H. (2022). Esports players, got muscle? Competitive video game players’ physical activity, body fat, bone mineral content, and muscle mass in comparison to matched controls. In Journal of Sport and Health Science (Vol. 11, Issue 6, pp. 725–730). Elsevier BV. <a href="https://doi.org/10.1016/j.jshs.2020.07.006">https://doi.org/10.1016/j.jshs.2020.07.006</a></span> body composition body mass index gaming https://repository.nyitlibrary.org/files/original/f7057fd6ee58739b43e0eb1fc5fe61b2.pdf 249c4eecc3d4b31feb66420d572b33ee Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource NYITCOM - Faculty Publications Publication Book or Journal Article published by New York Tech Facility. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Adaptations for Bipedal Walking: Musculoskeletal Structure and Three-Dimensional Joint Mechanics of Humans and Bipedal Chimpanzees (Pan troglodytes) Identifier An unambiguous reference to the resource within a given context https://repository.nyitlibrary.org/files/original/f7057fd6ee58739b43e0eb1fc5fe61b2.pdf https://doi.org/10.1016/j.jhevol.2022.103195 Creator An entity primarily responsible for making the resource O’Neill, M. C., Demes, B., Thompson, N. E., Larson, S. G., Stern, J. T., Jr., & Umberger, B. R. Date A point or period of time associated with an event in the lifecycle of the resource 2022 Publisher An entity responsible for making the resource available Elsevier BV Subject The topic of the resource Bipedalism Elastic energy Force Locomotion Power Work Language A language of the resource English Abstract A summary of the resource. Humans are unique among apes and other primates in the musculoskeletal design of their lower back, pelvis, and lower limbs. Here, we describe the three-dimensional ground reaction forces and lower/hindlimb joint mechanics of human and bipedal chimpanzees walking over a full stride and test whether: 1) the estimated limb joint work and power during the stance phase, especially the single-support period, is lower in humans than bipedal chimpanzees, 2) the limb joint work and power required for limb swing is lower in humans than in bipedal chimpanzees, and 3) the estimated total mechanical power during walking, accounting for the storage of passive elastic strain energy in humans, is lower in humans than in bipedal chimpanzees. Humans and bipedal chimpanzees were compared at matched dimensionless and dimensional velocities. Our results indicate that humans walk with significantly less work and power output in the first double-support period and the single-support period of stance, but markedly exceed chimpanzees in the second double-support period (i.e., push-off). Humans generate less work and power in limb swing, although the species difference in limb swing power was not statistically significant. We estimated that total mechanical positive 'muscle fiber' work and power were 46.9% and 35.8% lower, respectively, in humans than in bipedal chimpanzees at matched dimensionless speeds. This is due in part to mechanisms for the storage and release of elastic energy at the ankle and hip in humans. Furthermore, these results indicate distinct 'heel strike' and 'lateral balance' mechanics in humans and bipedal chimpanzees and suggest a greater dissipation of mechanical energy through soft tissue deformations in humans. Together, our results document important differences between human and bipedal chimpanzee walking mechanics over a full stride, permitting a more comprehensive understanding of the mechanics and energetics of chimpanzee bipedalism and the evolution of hominin walking. Source A related resource from which the described resource is derived <em>Journal of Human Evolution </em>Volune 168, July 2022, page 103195 Rights Information about rights held in and over the resource <span>This article is available under the </span><a target="_blank" href="https://creativecommons.org/licenses/" rel="noreferrer noopener">Creative Commons CC-BY-NC-ND</a><span> license and permits non-commercial use of the work as published, without adaptation or alteration provided the work is fully attributed.</span> Format The file format, physical medium, or dimensions of the resource PDF Type The nature or genre of the resource Text Bibliographic Citation A bibliographic reference for the resource. Recommended practice is to include sufficient bibliographic detail to identify the resource as unambiguously as possible. <span>O’Neill, M. C., Demes, B., Thompson, N. E., Larson, S. G., Stern, J. T., Jr., &amp; Umberger, B. R. (2022). Adaptations for bipedal walking: Musculoskeletal structure and three-dimensional joint mechanics of humans and bipedal chimpanzees (Pan troglodytes). In Journal of Human Evolution (Vol. 168, p. 103195). Elsevier BV. <a href="https://doi.org/10.1016/j.jhevol.2022.103195">https://doi.org/10.1016/j.jhevol.2022.103195</a></span> bipedalism elastic energy force locomotion power work https://repository.nyitlibrary.org/files/original/667c55996f468c6e5304c4e1655510f0.pdf 2730525895d9909e5736cc7c9bb37af9 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource NYITCOM - Faculty Publications Publication Book or Journal Article published by New York Tech Facility. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Caffeine and Dobutamine Challenge Induces Bidirectional Ventricular Tachycardia in Normal Rats Identifier An unambiguous reference to the resource within a given context https://repository.nyitlibrary.org/files/original/667c55996f468c6e5304c4e1655510f0.pdf https://doi.org/10.1016/j.hroo.2020.08.005 Creator An entity primarily responsible for making the resource Zhang, C., & Zhang, Y. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Bidirectional ventricular tachycardia Caffeine Dantrolene Dobutamine Ventricular arrhythmia Language A language of the resource English Rights Information about rights held in and over the resource <h3>Copyright</h3> <div class="copyright">© 2020 Heart Rhythm Society. Published by Elsevier Inc.</div> <h3>User license</h3> <a href="http://creativecommons.org/licenses/by-nc-nd/4.0/" class="userLicLnk">Creative Commons Attribution – NonCommercial – NoDerivs (CC BY-NC-ND 4.0)</a><span> </span>|<span> </span> <div class="dropBlock reference-citations"><a href="https://www.heartrhythmopen.com/article/S2666-5018(20)30114-8/fulltext#" class="reference-citations__ctrl">How you can reuse</a><span> </span></div> Format The file format, physical medium, or dimensions of the resource PDF Abstract A summary of the resource. <div> <h4 class="u-h4 u-margin-m-top u-margin-xs-bottom">Background</h4> <p>Bidirectional<span> </span><a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/ventricular-tachycardia" title="Learn more about ventricular tachycardia from ScienceDirect's AI-generated Topic Pages" class="topic-link">ventricular tachycardia</a><span> </span>(BD-VT) is an intriguing arrhythmia, characterized by a beat-to-beat alternation of the QRS polarity on electrocardiogram. Currently there is no simple BD-VT animal model.</p> </div> <div> <h4 class="u-h4 u-margin-m-top u-margin-xs-bottom">Objective</h4> <p><span>We report a simple animal model of BD-VT induced by caffeine and <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/dobutamine" title="Learn more about dobutamine from ScienceDirect's AI-generated Topic Pages" class="topic-link">dobutamine</a> (C+D) challenge in normal rats in which the arrhythmia can be attenuated by </span><a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/dantrolene" title="Learn more about dantrolene from ScienceDirect's AI-generated Topic Pages" class="topic-link">dantrolene</a><span> (a <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/ryanodine-receptor" title="Learn more about ryanodine receptor from ScienceDirect's AI-generated Topic Pages" class="topic-link">ryanodine receptor</a> stabilizer) <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/therapeutic-procedure" title="Learn more about treatment from ScienceDirect's AI-generated Topic Pages" class="topic-link">treatment</a>, but not by the pacemaker <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/channel-blocker" title="Learn more about channel blocker from ScienceDirect's AI-generated Topic Pages" class="topic-link">channel blocker</a> <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/ivabradine" title="Learn more about ivabradine from ScienceDirect's AI-generated Topic Pages" class="topic-link">ivabradine</a> treatment.</span></p> </div> <div> <h4 class="u-h4 u-margin-m-top u-margin-xs-bottom">Methods</h4> <p>Adult (4–5 months old) Sprague-Dawley rats (both sexes) were randomized into C+D (n = 8, received caffeine 120 mg/kg intraperitoneally [IP] and dobutamine 60 μg/kg IP, sequentially) and control (n = 8) groups. In addition, a group of 7 rats were pretreated with dantrolene (10 mg/kg, IP) 30 minutes before the C+D challenge and another group of 8 rats were pretreated with ivabradine (5 mg/kg, IP) 30 minutes before the C+D challenge.</p> </div> <div> <h4 class="u-h4 u-margin-m-top u-margin-xs-bottom">Results</h4> <p><span>C+D challenge induced spontaneous <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/premature-ventricular-contraction" title="Learn more about premature ventricular contractions from ScienceDirect's AI-generated Topic Pages" class="topic-link">premature ventricular contractions</a> (PVCs) in 7 of 8 rats and BD-VT (lasted 4.3 ± 2.9 minutes, terminated spontaneously) in 6 of 8 (75%) rats. No <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/heart-ventricle-arrhythmia" title="Learn more about ventricular arrhythmia from ScienceDirect's AI-generated Topic Pages" class="topic-link">ventricular arrhythmia</a> was induced in the control group (</span><em>P</em><span> </span>&lt; .05 vs C+D group). Dantrolene treatment significantly decreased BD-VT (1 of 7 rats in the Dantrolene+C+D group vs 6 of 8 rats in C+D group,<span> </span><em>P</em><span> </span>&lt; .05). Ivabradine treatment did not affect C+D-induced BD-VT (7 of 8 rats in the Ivabradine+C+D group vs 6 of 8 in the C+D group,<span> </span><em>P</em><span> </span>&gt; .05).</p> </div> <div> <h4 class="u-h4 u-margin-m-top u-margin-xs-bottom">Conclusion</h4> <p>Caffeine and dobutamine challenge induces BD-VT in a majority of normal rats. Stabilizing<span> </span><a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/ryanodine-receptor-2" title="Learn more about cardiac ryanodine receptors from ScienceDirect's AI-generated Topic Pages" class="topic-link">cardiac ryanodine receptors</a><span> </span>with dantrolene treatment can significantly decrease the occurrence of BD-VT, but pacemaker channel blocker ivabradine treatment does not have effect in this animal model.</p> </div> Source A related resource from which the described resource is derived <em>Heart Rhythm O2</em>, Volume 1, Issue 5, December 2020, pages 359-367 Type The nature or genre of the resource Text Bibliographic Citation A bibliographic reference for the resource. Recommended practice is to include sufficient bibliographic detail to identify the resource as unambiguously as possible. <span>Zhang, C., &amp; Zhang, Y. (2020). Caffeine and dobutamine challenge induces bidirectional ventricular tachycardia in normal rats. In Heart Rhythm O2 (Vol. 1, Issue 5, pp. 359–367). Elsevier BV. <a href="https://doi.org/10.1016/j.hroo.2020.08.005">https://doi.org/10.1016/j.hroo.2020.08.005</a></span> Publisher An entity responsible for making the resource available Elsevier BV Bidirectional ventricular tachycardia Caffeine Dantrolene Dobutamine Ventricular arrhythmia