3 20 113 https://repository.nyitlibrary.org/files/original/09a4bcbf409ddd13afe0348f2f4a2b4c.pdf 12011a6730f217556dc05429fdd12087 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource NYITCOM - Faculty Publications Publication Book or Journal Article published by New York Tech Facility. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Triiodothyronine Maintains Cardiac Transverse-Tubule Structure and Function Identifier An unambiguous reference to the resource within a given context https://repository.nyitlibrary.org/files/original/09a4bcbf409ddd13afe0348f2f4a2b4c.pdf https://doi.org/10.1016/j.yjmcc.2021.06.010 Format The file format, physical medium, or dimensions of the resource PDF Creator An entity primarily responsible for making the resource Gilani, N., Wang, K., Muncan, A., Peter, J., An, S., Bhatti, S., Pandya, K., Zhang, Y., Tang, Y.-D., Gerdes, A. M., Stout, R. F., & Ojamaa, K. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Language A language of the resource English Abstract A summary of the resource. Subclinical hypothyroidism and low T3 syndrome are commonly associated with an increased risk of cardiovascular disease (CVD) and mortality. We examined effects of T3 on T-tubule (TT) structures, Ca 2+ mobilization and contractility, and clustering of dyadic proteins. Thyroid hormone (TH) deficiency was induced in adult female rats by propyl-thiouracil (PTU; 0.025%) treatment for 8 weeks. Rats were then randomized to continued PTU or triiodo-L-thyronine (T3; 10 μg/kg/d) treatment for 2 weeks (PTU + T3). After in vivo echocardiographic and hemodynamic recordings, cardiomyocytes (CM) were isolated to record Ca 2+ transients and contractility. TT organization was assessed by confocal microscopy, and STORM images were captured to measure ryanodine receptor (RyR2) cluster number and size, and L-type Ca 2+ channel (LTCC, Ca v 1.2) co-localization. Expressed genes including two integral TT proteins, junctophilin-2 (Jph-2) and bridging integrator-1 (BIN1), were analyzed in left ventricular (LV) tissues and cultured CM using qPCR and RNA sequencing. The T3 dosage used normalized serum T3, and reversed adverse effects of TH deficiency on in vivo measures of cardiac function. Recordings of isolated CM indicated that T3 increased rates of Ca 2+ release and re-uptake, resulting in increased velocities of sarcomere shortening and re-lengthening. TT periodicity was significantly decreased, with reduced transverse tubules but increased longitudinal tubules in TH-deficient CMs and LV tissue, and these structures were normalized by T3 treatment. Analysis of STORM data of PTU myocytes showed decreased RyR2 cluster numbers and RyR localizations within each cluster without significant changes in Ca v 1.2 localizations within RyR clusters. T3 treatment normalized RyR2 cluster size and number. qPCR and RNAseq analyses of LV and cultured CM showed that Jph2 expression was T3-responsive, and its increase with treatment may explain improved TT organization and RyR-LTCC coupling. Subject The topic of the resource Animals Ca(2+) Calcium Channels, L-Type metabolism Calcium Signaling drug effects Calcium metabolism Cells, Cultured Disease Models, Animal Female Gene Expression Heart Ventricles drug effects metabolism Hypothyroidism blood chemically induced drug therapy Index Medicus Junctophilin-2 Membrane Proteins genetics metabolism Myocytes, Cardiac metabolism Rats Ryanodine Receptor Calcium Release Channel metabolism Ryanodine receptors STORM SY7Q814VUP Sarcolemma metabolism Sarcomeres metabolism Thyroid hormone Transverse-tubules Treatment Outcome Triiodothyronine administration & dosage blood Ventricular Function drug effects Source A related resource from which the described resource is derived <em>Journal of Molecular and Cellular Cardiology</em>, Volume 160, November 2021, pages 1-14 Publisher An entity responsible for making the resource available Elsevier BV Rights Information about rights held in and over the resource Copyright © 2021 The Authors Type The nature or genre of the resource Text Bibliographic Citation A bibliographic reference for the resource. Recommended practice is to include sufficient bibliographic detail to identify the resource as unambiguously as possible. <span>Gilani, N., Wang, K., Muncan, A., Peter, J., An, S., Bhatti, S., Pandya, K., Zhang, Y., Tang, Y.-D., Gerdes, A. M., Stout, R. F., &amp; Ojamaa, K. (2021). Triiodothyronine maintains cardiac transverse-tubule structure and function. In Journal of Molecular and Cellular Cardiology (Vol. 160, pp. 1–14). Elsevier BV. <a href="https://doi.org/10.1016/j.yjmcc.2021.06.010">https://doi.org/10.1016/j.yjmcc.2021.06.010</a></span> https://repository.nyitlibrary.org/files/original/6cf271c0c7cc2bfcfe261ec3fbe66313.pdf 428d47b8c9183247e73f11b8858ea1fc Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource NYITCOM - Faculty Publications Publication Book or Journal Article published by New York Tech Facility. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Are endocasts good proxies for brain size and shape in archosaurs throughout ontogeny? Identifier An unambiguous reference to the resource within a given context https://repository.nyitlibrary.org/files/original/6cf271c0c7cc2bfcfe261ec3fbe66313.pdf https://doi.org/10.1111/joa.12918 Creator An entity primarily responsible for making the resource Watanabe, A., Gignac, P. M., Balanoff, A. M., Green, T. L., Kley, N. J., & Norell, M. A. Publisher An entity responsible for making the resource available Wiley Subject The topic of the resource Alligator Gallus Diffusible iodine-based contrast-enhanced computed tomography Geometric morphometrics Micro-computed tomography Neuroanatomy Language A language of the resource English Abstract A summary of the resource. Cranial endocasts, or the internal molds of the braincase, are a crucial correlate for investigating the neuroanatomy of extinct vertebrates and tracking brain evolution through deep time. Nevertheless, the validity of such studies pivots on the reliability of endocasts as a proxy for brain morphology. Here, we employ micro-computed tomography imaging, including diffusible iodine-based contrast-enhanced CT, and a three-dimensional geometric morphometric framework to examine both size and shape differences between brains and endocasts of two exemplar archosaur taxa – the American alligator (Alligator mississippiensis) and the domestic chicken (Gallus gallus). With ontogenetic sampling, we quantitatively evaluate how endocasts differ from brains and whether this deviation changes during development. We find strong size and shape correlations between brains and endocasts, divergent ontogenetic trends in the brain-to-endocast correspondence between alligators and chickens, and a comparable magnitude between brain–endocast shape differences and intraspecific neuroanatomical variation. The results have important implications for paleoneurological studies in archosaurs. Notably, we demonstrate that the pattern of endocranial shape variation closely reflects brain shape variation. Therefore, analyses of endocranial morphology are unlikely to generate spurious conclusions about large-scale trends in brain size and shape. To mitigate any artifacts, however, paleoneurological studies should consider the lower brain–endocast correspondence in the hindbrain relative to the forebrain; higher size and shape correspondences in chickens than alligators throughout postnatal ontogeny; artificially ‘pedomorphic’ shape of endocasts relative to their corresponding brains; and potential biases in both size and shape data due to the lack of control for ontogenetic stages in endocranial sampling. Format The file format, physical medium, or dimensions of the resource PDF Date A point or period of time associated with an event in the lifecycle of the resource 2019 Source A related resource from which the described resource is derived <em>Journal of Anatomy</em>, Volume 234, Issue 3, December 2018, pages 291-305 Rights Information about rights held in and over the resource Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) Type The nature or genre of the resource Text Bibliographic Citation A bibliographic reference for the resource. Recommended practice is to include sufficient bibliographic detail to identify the resource as unambiguously as possible. <span>Watanabe, A., Gignac, P. M., Balanoff, A. M., Green, T. L., Kley, N. J., &amp; Norell, M. A. (2018). Are endocasts good proxies for brain size and shape in archosaurs throughout ontogeny? In Journal of Anatomy (Vol. 234, Issue 3, pp. 291–305). Wiley. <a href="https://doi.org/10.1111/joa.12918">https://doi.org/10.1111/joa.12918</a></span> Alligator Alligators and Crocodiles anatomy and histology animal animal experiment animal model Animals article artifact Biological Evolution brain size chicken Computer-Assisted contrast enhancement controlled study crocodilian diffusible iodine-based contrast-enhanced computed tomography evolution forebrain Gallus geometric morphometrics Image Processing micro-computed tomography morphology morphometry neuroanatomy nonhuman ontogeny procedures quantitative analysis rhombencephalon sampling skull Tomography writing X-Ray Computed x-ray computed tomography X-Ray Microtomography https://repository.nyitlibrary.org/files/original/1b7fdd8807458f5f84407113bf7f73ff.pdf d844e5593cafe534aac42d9264e8b400 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource NYITCOM - Faculty Publications Publication Book or Journal Article published by New York Tech Facility. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Thresholding Segmentation Errors and Uncertainty with Patient-Specific Geometries Identifier An unambiguous reference to the resource within a given context https://repository.nyitlibrary.org/files/original/1b7fdd8807458f5f84407113bf7f73ff.pdf <a href="https://doi.org/10.31661%2Fjbpe.v0i0.2001-1062">https://doi.org/10.31661%2Fjbpe.v0i0.2001-1062</a> <a href="https://doaj.org/article/4b222bc346244da8bc0d3a4e795f4471">https://doaj.org/article/4b222bc346244da8bc0d3a4e795f4471</a> Creator An entity primarily responsible for making the resource Toma, M., Lu, Y., Zhou, H., & Garcia, J.D. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource Medical physics Medical radiology Nuclear medicine Image processing, computer-assisted, errors Patient-specific modeling Thresholding Uncertainty Language A language of the resource English Abstract A summary of the resource. Computer simulations provide virtual hands-on experience when actual hands-on experience is not possible. To use these simulations in medical science, they need to be able to predict the behavior of actual processes with actual patient-specific geometries. Many uncertainties enter in the process of developing these simulations, starting with creating the geometry. The actual patient-specific geometry is often complex and hard to process. Usually, simplifications to the geometry are introduced in exchange for faster results. However, when simplified, these simulations can no longer be considered patient-specific as they do not represent the actual patient they come from. The ultimate goal is to keep the geometries truly patient-specific without any simplification. However, even without simplifications, the patient-specific geometries are based on medical imaging modalities and consequent use of numerical algorithms to create and process the 3D surface. Multiple users are asked to process medical images of a complex geometry. Their resulting geometries are used to assess how the user’s choices determine the resulting dimensions of the 3D model. It is shown that the resulting geometry heavily depends on user’s choices. Source A related resource from which the described resource is derived <em>Journal of Biomedical Physics and Engineering</em>, Volume 11, Issue 1, February 2021, pages 115-122 Format The file format, physical medium, or dimensions of the resource PDF Publisher An entity responsible for making the resource available Salvia Medical Sciences Ltd. Rights Information about rights held in and over the resource Copyright: © Journal of Biomedical Physics and Engineering. Type The nature or genre of the resource Text Bibliographic Citation A bibliographic reference for the resource. Recommended practice is to include sufficient bibliographic detail to identify the resource as unambiguously as possible. <span>Toma, M. (2021). Thresholding Segmentation Errors and Uncertainty with Patient-Specific Geometries. In Journal of Biomedical Physics and Engineering (Vol. 11, Issue 1). Salvia Medical Sciences Ltd. <a href="https://doi.org/10.31661/jbpe.v0i0.2001-1062">https://doi.org/10.31661/jbpe.v0i0.2001-1062</a></span> Computer-Assisted Errors Image Processing Patient-Specific Modeling Thresholding Uncertainty https://repository.nyitlibrary.org/files/original/b6dba06505452c0b27144634e6c9c02b.pdf e42d9eee30301c38cd88a93b1b29225f Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource NYITCOM - Faculty Publications Publication Book or Journal Article published by New York Tech Facility. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Pulsatile Flow Investigation in Development of Thoracic Aortic Aneurysm: An In-Vitro Validated Fluid Structure Interaction Analysis Identifier An unambiguous reference to the resource within a given context https://repository.nyitlibrary.org/files/original/1b7fdd8807458f5f84407113bf7f73ff.pdf <a href="https://doi.org/10.29252/jafm.12.06.29769">https://doi.org/10.29252/jafm.12.06.29769</a> Creator An entity primarily responsible for making the resource Ong, C. W., Kabinejadian, F., Xiong, F., Wong, Y. R., Toma, M., Nguyen, Y. N., Chua, K. J., Cui, F. S., Ho, P., & Leo, H. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource Mechanical engineering and machinery Thoracic aortic aneurysm Particle image velocimetry Thrombus Fluid structure interaction (FSI) Hemodynamics Language A language of the resource English Abstract A summary of the resource. Thoracic aortic aneurysm (TAA) is a severe cardiovascular disease with a high mortality rate, if left untreated. Clinical observations show that aneurysm growth can be linked to undesirable hemodynamic conditions of the aortic aneurysm. In order to gain more insight on TAA formation, we developed a computational framework in vitro to investigate and compare the flow patterns between pre-aneurismal and post-aneurismal aorta using a deformable wall model. This numerical framework was validated by an in vitro experiment accounting for the patient-specific geometrical features and the physiological conditions. The complex flow behaviors in the pre-aneurismal and post-aneurismal aorta were evaluated experimentally by particle image velocimetry (PIV). Our experimental results demonstrated flow behaviors similar to those observed in the fluid-structure interaction (FSI) numerical study. We observed a small vortex induced by the non-planarity of pre-aneurismal aorta near the aortic arch in pre-aneurysmal aorta may explain the aneurysm formation at the aortic arch. We found that high endothelial cell action potential (ECAP) correlates with the recirculation regions, which might indicate possible thrombus development. The promising image-based fluid-structure interaction model, accompanied with an in vitro experimental study, has the potential to be used for performing virtual implantation of newly developed stent graft for treatment of TAA. Source A related resource from which the described resource is derived <em>Journal of Applied Fluid Mechanics</em>, Volume 12, Issue 6, January 2019, pages 1855–1872 Rights Information about rights held in and over the resource <span>This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.</span> Format The file format, physical medium, or dimensions of the resource PDF Type The nature or genre of the resource Text Bibliographic Citation A bibliographic reference for the resource. Recommended practice is to include sufficient bibliographic detail to identify the resource as unambiguously as possible. <span>Ong, C. W., Kabinejadian, F., Xiong, F., Wong, Y. R., Toma, M., Nguyen, Y. N., Chua, K. J., Cui, F. S., Ho, P., &amp; Leo, H. (2019). Pulsatile Flow Investigation in Development of Thoracic Aortic Aneurysm: An In-Vitro Validated Fluid Structure Interaction Analysis. In Journal of Applied Fluid Mechanics (Vol. 12, Issue 6, pp. 1855–1872). Academic World Research. <a href="https://doi.org/10.29252/jafm.12.06.29769">https://doi.org/10.29252/jafm.12.06.29769</a></span> Publisher An entity responsible for making the resource available Academic World Research Fluid structure interaction (FSI) Hemodynamics Particle image velocimetry Thoracic aortic aneurysm Thrombus https://repository.nyitlibrary.org/files/original/b29c848cdee5d8414366c1fb5b907a0f.pdf aa5312bb540f3ace0b327eab3f3f14d0 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource NYITCOM - Faculty Publications Publication Book or Journal Article published by New York Tech Facility. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Long genes linked to autism spectrum disorders harbor broad enhancer-like chromatin domains Identifier An unambiguous reference to the resource within a given context https://repository.nyitlibrary.org/files/original/1b7fdd8807458f5f84407113bf7f73ff.pdf <a href="https://doi.org/10.1101/gr.233775.117">https://doi.org/10.1101/gr.233775.117</a> Creator An entity primarily responsible for making the resource Zhao, Y.-T., Kwon, D. Y., Johnson, B. S., Fasolino, M., Lamonica, J. M., Kim, Y. J., Zhao, B. S., He, C., Vahedi, G., Kim, T. H., & Zhou, Z. Date A point or period of time associated with an event in the lifecycle of the resource 2018 Subject The topic of the resource Animals Autism Spectrum Disorder genetics Autistic Disorder genetics Chromatin genetics Humans Index Medicus Male Mice Mice, Inbred C57BL Mutation genetics Neurogenesis genetics RNA Polymerase II genetics Regulatory Sequences, Nucleic Acid genetics Transcription, Genetic genetics Language A language of the resource English Abstract A summary of the resource. Genetic variants associated with autism spectrum disorders (ASDs) are enriched in genes encoding synaptic proteins and chromatin regulators. Although the role of synaptic proteins in ASDs is widely studied, the mechanism by which chromatin regulators contribute to ASD risk remains poorly understood. Upon profiling and analyzing the transcriptional and epigenomic features of genes expressed in the cortex, we uncovered a unique set of long genes that contain broad enhancer-like chromatin domains (BELDs) spanning across their entire gene bodies. Analyses of these BELD genes show that they are highly transcribed with frequent RNA polymerase II (Pol II) initiation and low Pol II pausing, and they exhibit frequent chromatin–chromatin interactions within their gene bodies. These BELD features are conserved from rodents to humans, are enriched in genes involved in synaptic function, and appear post-natally concomitant with synapse development. Importantly, we find that BELD genes are highly implicated in neurodevelopmental disorders, particularly ASDs, and that their expression is preferentially down-regulated in individuals with idiopathic autism. Finally, we find that the transcription of BELD genes is particularly sensitive to alternations in ASD-associated chromatin regulators. These findings suggest that the epigenomic regulation of BELD genes is important for post-natal cortical development and lend support to a model by which mutations in chromatin regulators causally contribute to ASDs by preferentially impairing BELD gene transcription. Source A related resource from which the described resource is derived <em>Genome Research</em>, Volume 28, Issue 7, May 2018, pages 933-942 Format The file format, physical medium, or dimensions of the resource PDF Publisher An entity responsible for making the resource available Cold Spring Harbor Laboratory Rights Information about rights held in and over the resource © 2018 Zhao et al.; Published by Cold Spring Harbor Laboratory Press Type The nature or genre of the resource Text Bibliographic Citation A bibliographic reference for the resource. Recommended practice is to include sufficient bibliographic detail to identify the resource as unambiguously as possible. <span>Zhao, Y.-T., Kwon, D. Y., Johnson, B. S., Fasolino, M., Lamonica, J. M., Kim, Y. J., Zhao, B. S., He, C., Vahedi, G., Kim, T. H., &amp; Zhou, Z. (2018). Long genes linked to autism spectrum disorders harbor broad enhancer-like chromatin domains. In Genome Research (Vol. 28, Issue 7, pp. 933–942). Cold Spring Harbor Laboratory. <a href="https://doi.org/10.1101/gr.233775.117">https://doi.org/10.1101/gr.233775.117</a></span> animal animal experiment animal model Animals article attention deficit disorder autism Autism Spectrum Disorder Autistic Disorder brain cell C57BL mouse chromatin comparative study controlled study DNA isolation down regulation enhancer like chromatin domain enhancer region epigenetics gene control gene frequency gene identification Genetic genetic analysis genetic association genetic code genetic linkage genetic risk genetic transcription genetic variability genetics histone modification human Humans immunoprecipitation Inbred C57BL intellectual impairment loss of function mutation male Mice mouse mutation nervous system development Neuro-2a cell line Neurogenesis nonhuman Nucleic Acid priority journal promoter region real time polymerase chain reaction regulatory sequence Regulatory Sequences reverse transcription polymerase chain reaction risk factor RNA polymerase II RNA sequence small interfering RNA transcription transcription initiation transcription initiation site https://repository.nyitlibrary.org/files/original/c6ed436027cdd74f6ada2d4de3f634a0.pdf f37339d0afa5a16e18f8dc284627a1c7 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource NYITCOM - Faculty Publications Publication Book or Journal Article published by New York Tech Facility. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Fossil Apes and Human Evolution Identifier An unambiguous reference to the resource within a given context https://repository.nyitlibrary.org/files/original/c6ed436027cdd74f6ada2d4de3f634a0.pdf <a href="https://doi.org/10.1126/science.abb4363">https://doi.org/10.1126/science.abb4363</a> Creator An entity primarily responsible for making the resource Almécija, S., Hammond, A. S., Thompson, N. E., Pugh, K. D., Moyà-Solà, S., & Alba, D. M. Subject The topic of the resource Animals Biological Evolution Fossils Hominidae anatomy & histology classification Humans Index Medicus Phylogeny Language A language of the resource English Abstract A summary of the resource. Humans diverged from apes (chimpanzees, specifically) toward the end of the Miocene ~9.3 million to 6.5 million years ago. Understanding the origins of the human lineage (hominins) requires reconstructing the morphology, behavior, and environment of the chimpanzee-human last common ancestor. Modern hominoids (that is, humans and apes) share multiple features (for example, an orthograde body plan facilitating upright positional behaviors). However, the fossil record indicates that living hominoids constitute narrow representatives of an ancient radiation of more widely distributed, diverse species, none of which exhibit the entire suite of locomotor adaptations present in the extant relatives. Hence, some modern ape similarities might have evolved in parallel in response to similar selection pressures. Current evidence suggests that hominins originated in Africa from Miocene ape ancestors unlike any living species. Source A related resource from which the described resource is derived <em>Science</em>, Volume 372, Issue 6542, May 2021 Date A point or period of time associated with an event in the lifecycle of the resource 2021 Format The file format, physical medium, or dimensions of the resource PDF Publisher An entity responsible for making the resource available American Association for the Advancement of Science (AAAS) Rights Information about rights held in and over the resource <div>Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.</div> <div><a href="https://www.sciencemag.org/about/science-licenses-journal-article-reuse?adobe_mc=MCMID%3D49365048756730316000997922049602443404%7CMCORGID%3D242B6472541199F70A4C98A6%2540AdobeOrg%7CTS%3D1698439059">https://www.sciencemag.org/about/science-licenses-journal-article-reuse</a></div> <div>This is an article distributed under the terms of the<span> </span><a href="http://www.sciencemag.org/about/science-licenses-journal-article-reuse?adobe_mc=MCMID%3D49365048756730316000997922049602443404%7CMCORGID%3D242B6472541199F70A4C98A6%2540AdobeOrg%7CTS%3D1698439059">Science Journals Default License</a>.</div> Type The nature or genre of the resource Text Bibliographic Citation A bibliographic reference for the resource. Recommended practice is to include sufficient bibliographic detail to identify the resource as unambiguously as possible. <span>Almécija, S., Hammond, A. S., Thompson, N. E., Pugh, K. D., Moyà-Solà, S., &amp; Alba, D. M. (2021). Fossil apes and human evolution. In Science (Vol. 372, Issue 6542). American Association for the Advancement of Science (AAAS). <a href="https://doi.org/10.1126/science.abb4363">https://doi.org/10.1126/science.abb4363</a></span> adaptation Africa anatomy and histology animal Animals Biological Evolution chimpanzee classification evolution fossil fossil hominoid fossil record Fossils hominid Hominidae human human evolution Humans last common ancestor Miocene morphology natural selection nonhuman Phylogeny primate relative Review https://repository.nyitlibrary.org/files/original/1acd23bae6fa651e239ba264789c5200.pdf 5a83396f650a782c6e280f1c1798045a Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource NYITCOM - Faculty Publications Publication Book or Journal Article published by New York Tech Facility. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Fluid-Structure Interaction Analyses of Amniotic Fluid with a Comprehensive Fetus Model Exposed to External Loading Identifier An unambiguous reference to the resource within a given context https://repository.nyitlibrary.org/files/original/1acd23bae6fa651e239ba264789c5200.pdf <a href="https://doi.org/10.1016/j.injury.2023.110843">https://doi.org/10.1016/j.injury.2023.110843</a> Creator An entity primarily responsible for making the resource Arias, J., Kurgansky, G., Wei, O. C., Chan-Akeley, R., & Toma, M Date A point or period of time associated with an event in the lifecycle of the resource 2022 Publisher An entity responsible for making the resource available Elsevier BV Subject The topic of the resource Fluid-Structure Interaction Amniotic Fluid Fetus Smoothed-Particle Hydrodynamics Language A language of the resource English Abstract A summary of the resource. <div class="abstract-content selected"> <p><strong class="sub-title">Introduction:<span> </span></strong>Pregnancy-related trauma is one of the leading causes of morbidity and mortality in pregnant women and fetuses. The fetal response to injury is largely dependent on the timing of fetal presentation and the underlying pathophysiology of the trauma. The optimal management of pregnant patients who have suffered an obstetric emergency depends on clinical assessment and understanding of the placental implantation process, which can be difficult to perform during an emergency. Understanding the mechanisms of traumatic injuries to the fetus is crucial for developing next-generation protective devices.</p> <p><strong class="sub-title">Methods:<span> </span></strong>This study aimed to investigate the effect of amniotic fluid on mine blast on the uterus, fetus, and placenta via computational analysis. Finite element models were developed to analyze the effects of explosion forces on the uterus, fetus, and placenta, based on cadaveric data obtained from the literature. This study uses computational fluid-structure interaction simulations to study the effect of external loading on the fetus submerged in amniotic fluid inside of the uterus.</p> <p><strong class="sub-title">Results:<span> </span></strong>Computational fluid-structure interaction simulations are used to study the effect of external loading on the fetus/placenta submerged in amniotic fluid inside the uterus. Cushioning function of the amniotic fluid on the fetus and placenta is demonstrated. The mechanism of traumatic injuries to the fetus/placenta is shown.</p> <p><strong class="sub-title">Discussion:<span> </span></strong>The intention of this research is to understand the cushioning function of the amniotic fluid on the fetus. Further, it is important to make use of this knowledge in order to ensure the safety of pregnant women and their fetuses.</p> </div> <p><strong class="sub-title">Keywords:<span> </span></strong>Amniotic fluid; FSI; Fetus; Fluid-structure interaction; Placenta.</p> Source A related resource from which the described resource is derived <em>Injury</em>, Volume 54, Issue 8, August 2023, page 110843 Rights Information about rights held in and over the resource Copyright © 2023 Elsevier Ltd. All rights reserved. Format The file format, physical medium, or dimensions of the resource PDF Type The nature or genre of the resource Text Bibliographic Citation A bibliographic reference for the resource. Recommended practice is to include sufficient bibliographic detail to identify the resource as unambiguously as possible. <span>Arias, J., Kurgansky, G., Wei, O. C., Chan-Akeley, R., &amp; Toma, M. (2023). Fluid-structure interaction analysis of amniotic fluid with fetus and placenta inside uterus exposed to military blasts. In Injury (Vol. 54, Issue 8, p. 110843). Elsevier BV. <a href="https://doi.org/10.1016/j.injury.2023.110843">https://doi.org/10.1016/j.injury.2023.110843</a></span> Amniotic Fluid Fetus fluid-structure interaction smoothed-particle hydrodynamics https://repository.nyitlibrary.org/files/original/247fa735fc0f1dbe794c4196fae1a8d1.pdf 45a6d410531e066067aba0bcb34ee7c5 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource NYITCOM - Faculty Publications Publication Book or Journal Article published by New York Tech Facility. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Cannabidiol (CBD) as a Promising Anti-Cancer Drug Identifier An unambiguous reference to the resource within a given context https://repository.nyitlibrary.org/files/original/247fa735fc0f1dbe794c4196fae1a8d1.pdf <a href="https://doi.org/10.3390/cancers12113203">https://doi.org/10.3390/cancers12113203</a> Creator An entity primarily responsible for making the resource Seltzer, E. S., Watters, A. K., MacKenzie, D., Jr., Granat, L. M., & Zhang, D. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource CBD Cannabidiol Cannbinoids Anti-cancer drug Language A language of the resource English Abstract A summary of the resource. Recently, cannabinoids, such as cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC), have been the subject of intensive research and heavy scrutiny. Cannabinoids encompass a wide array of organic molecules, including those that are physiologically produced in humans, synthesized in laboratories, and extracted primarily from the Cannabis sativa plant. These organic molecules share similarities in their chemical structures as well as in their protein binding profiles. However, pronounced differences do exist in their mechanisms of action and clinical applications, which will be briefly compared and contrasted in this review. The mechanism of action of CBD and its potential applications in cancer therapy will be the major focus of this review article. Source A related resource from which the described resource is derived <em>Cancers</em>, Volume 12, Issue 11, October 2020, page 3203 Format The file format, physical medium, or dimensions of the resource PDF Rights Information about rights held in and over the resource <span>© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (</span><a href="http://creativecommons.org/licenses/by/4.0/" target="_blank" rel="noreferrer noopener">http://creativecommons.org/licenses/by/4.0/</a><span>).</span> Type The nature or genre of the resource Text Bibliographic Citation A bibliographic reference for the resource. Recommended practice is to include sufficient bibliographic detail to identify the resource as unambiguously as possible. <span>Seltzer, E. S., Watters, A. K., MacKenzie, D., Jr., Granat, L. M., &amp; Zhang, D. (2020). Cannabidiol (CBD) as a Promising Anti-Cancer Drug. In Cancers (Vol. 12, Issue 11, p. 3203). MDPI AG. <a href="https://doi.org/10.3390/cancers12113203">https://doi.org/10.3390/cancers12113203</a></span> Publisher An entity responsible for making the resource available MDPI AG anti-cancer drug cannabidiol cannabinoids; cannabidiol; CBD; anti-cancer drucannabinoids CBD https://repository.nyitlibrary.org/files/original/5f4d0a05b468fb97ccfa623ce3e3a322.pdf 508f2f7d92c7faa6920bacc605436e5a Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource NYITCOM - Faculty Publications Publication Book or Journal Article published by New York Tech Facility. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Addressing Discrepancies between Experimental and Computational Procedures Identifier An unambiguous reference to the resource within a given context https://repository.nyitlibrary.org/files/original/5f4d0a05b468fb97ccfa623ce3e3a322.pdf <a href="https://doi.org/10.3390/biology10060536">https://doi.org/10.3390/biology10060536</a> Creator An entity primarily responsible for making the resource Toma, M., Guru, S. K., Wu, W., Ali, M., & Ong, C. W. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource Chordae Tendineae Chordal Structure Comprehensive Computational Model Fluid-Structure Interaction Heart Valve Smooth Particle Hydrodynamics Language A language of the resource English Abstract A summary of the resource. Imaging subject-specific heart valve, a crucial step to its design, has experimental variables that if unaccounted for, may lead to erroneous computational analysis and geometric errors of the resulting model. Preparation methods are developed to mitigate some sources of the geometric error. However, the resulting 3D geometry often does not retain the original dimensions before excision. Inverse fluid–structure interaction analysis is used to analyze the resulting geometry and to assess the valve’s closure. Based on the resulting closure, it is determined if the geometry used can yield realistic results. If full closure is not reached, the geometry is adjusted adequately until closure is observed. Source A related resource from which the described resource is derived <em>Biology</em>, Volume 10, Issue 6, June 2021, page 536 Rights Information about rights held in and over the resource <span>© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (</span><a href="https://creativecommons.org/licenses/by/4.0/" target="_blank" rel="noreferrer noopener">https://creativecommons.org/licenses/by/4.0/</a><span>).</span> Format The file format, physical medium, or dimensions of the resource PDF Type The nature or genre of the resource Text Bibliographic Citation A bibliographic reference for the resource. Recommended practice is to include sufficient bibliographic detail to identify the resource as unambiguously as possible. <span>Toma, M., Guru, S. K., Wu, W., Ali, M., &amp; Ong, C. W. (2021). Addressing Discrepancies between Experimental and Computational Procedures. In Biology (Vol. 10, Issue 6, p. 536). MDPI AG. <a href="https://doi.org/10.3390/biology10060536">https://doi.org/10.3390/biology10060536</a></span> Publisher An entity responsible for making the resource available MDPI AG chordae tendineae chordal structure comprehensive computational model fixation fluid–structure interaction heart valve inverse finite element smooth particle hydrodynamics https://repository.nyitlibrary.org/files/original/9fe4b328d3fbbaf0d0c53708bb221980.pdf 4e9b54a564916fe332bb603213a26218 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource NYITCOM - Faculty Publications Publication Book or Journal Article published by New York Tech Facility. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Fluid–Structure Interaction Analyses of Biological Systems Using Smoothed-Particle Hydrodynamics Identifier An unambiguous reference to the resource within a given context https://repository.nyitlibrary.org/files/original/9fe4b328d3fbbaf0d0c53708bb221980.pdf <a href="https://doi.org/10.3390/biology10030185">https://doi.org/10.3390/biology10030185</a> Creator An entity primarily responsible for making the resource Toma, M., Chan-Akeley, R., Arias, J., Kurgansky, G. D., & Mao, W. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource Biological Systems Fluid–Structure Interaction Numerical Analyses Simulation Smoothed-Particle Hydrodynamics Language A language of the resource English Abstract A summary of the resource. Due to the inherent complexity of biological applications that more often than not include fluids and structures interacting together, the development of computational fluid–structure interaction models is necessary to achieve a quantitative understanding of their structure and function in both health and disease. The functions of biological structures usually include their interactions with the surrounding fluids. Hence, we contend that the use of fluid–structure interaction models in computational studies of biological systems is practical, if not necessary. The ultimate goal is to develop computational models to predict human biological processes. These models are meant to guide us through the multitude of possible diseases affecting our organs and lead to more effective methods for disease diagnosis, risk stratification, and therapy. This review paper summarizes computational models that use smoothed-particle hydrodynamics to simulate the fluid–structure interactions in complex biological systems. Source A related resource from which the described resource is derived <em>Biology</em>, Volume 10, Issue 3, March 2021, page 185 Format The file format, physical medium, or dimensions of the resource PDF Publisher An entity responsible for making the resource available MDPI AG Rights Information about rights held in and over the resource <div class="fm-copyright half_rhythm"><a href="https://www.ncbi.nlm.nih.gov/pmc/about/copyright/">Copyright</a><span> </span>© 2021 by the authors.</div> <div class="license half_rhythm">Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (<a href="https://creativecommons.org/licenses/by/4.0/" target="_blank" rel="noreferrer noopener">http://creativecommons.org/licenses/by/4.0/</a>).</div> Type The nature or genre of the resource Text Bibliographic Citation A bibliographic reference for the resource. Recommended practice is to include sufficient bibliographic detail to identify the resource as unambiguously as possible. <span>Toma, M., Chan-Akeley, R., Arias, J., Kurgansky, G. D., &amp; Mao, W. (2021). Fluid–Structure Interaction Analyses of Biological Systems Using Smoothed-Particle Hydrodynamics. In Biology (Vol. 10, Issue 3, p. 185). MDPI AG. <a href="https://doi.org/10.3390/biology10030185">https://doi.org/10.3390/biology10030185</a></span> biological systems fluid–structure interaction numerical analyses simulation smoothed-particle hydrodynamics https://repository.nyitlibrary.org/files/original/a78119b80c74d27c18d21fd494fdfe2e.pdf 4084abe6721ff90e0325bf36c4c0cfb9 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource NYITCOM - Faculty Publications Publication Book or Journal Article published by New York Tech Facility. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Effect of Edge-to-Edge Mitral Valve Repair on Chordal Strain: Fluid-Structure Interaction Simulations Identifier An unambiguous reference to the resource within a given context https://repository.nyitlibrary.org/files/original/a78119b80c74d27c18d21fd494fdfe2e.pdf <a href="https://doi.org/10.3390/biology9070173">https://doi.org/10.3390/biology9070173</a> Creator An entity primarily responsible for making the resource Toma, M., Einstein, D. R., Kohli, K., Caroll, S. L., Bloodworth, C. H., IV, Cochran, R. P., Kunzelman, K. S., & Yoganathan, A. P. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Abstract A summary of the resource. Edge-to-edge repair for mitral valve regurgitation is being increasingly performed in high-surgical risk patients using minimally invasive mitral clipping devices. Known procedural complications include chordal rupture and mitral leaflet perforation. Hence, it is important to quantitatively evaluate the effect of edge-to-edge repair on chordal integrity. in this study, we employ a computational mitral valve model to simulate functional mitral regurgitation (FMR) by creating papillary muscle displacement. Edge-to-edge repair is then modeled by simulated coaptation of the mid portion of the mitral leaflets. in the setting of simulated FMR, edge-to-edge repair was shown to sustain low regurgitant orifice area, until a two fold increase in the inter-papillary muscle distance as compared to the normal mitral valve. Strain in the chordae was evaluated near the papillary muscles and the leaflets. Following edge-to-edge repair, strain near the papillary muscles did not significantly change relative to the unrepaired valve, while strain near the leaflets increased significantly relative to the unrepaired valve. These data demonstrate the potential for computational simulations to aid in the pre-procedural evaluation of possible complications such as chordal rupture and leaflet perforation following percutaneous edge-to-edge repair. Source A related resource from which the described resource is derived <em>Biology</em>, Volume 9, Issue 7, July 2020, page 173 Format The file format, physical medium, or dimensions of the resource PDF Subject The topic of the resource Chordae tendineae Chordal strain Comprehensive model Computer simulation Edge-to-edge repair Fluid-structure interaction Mitral valve Publisher An entity responsible for making the resource available MDPI AG Language A language of the resource English Rights Information about rights held in and over the resource <span>© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (</span><a href="http://creativecommons.org/licenses/by/4.0/" target="_blank" rel="noreferrer noopener">http://creativecommons.org/licenses/by/4.0/</a><span>).</span> Type The nature or genre of the resource Text Bibliographic Citation A bibliographic reference for the resource. Recommended practice is to include sufficient bibliographic detail to identify the resource as unambiguously as possible. <span>Toma, M., Einstein, D. R., Kohli, K., Caroll, S. L., Bloodworth, C. H., IV, Cochran, R. P., Kunzelman, K. S., &amp; Yoganathan, A. P. (2020). Effect of Edge-to-Edge Mitral Valve Repair on Chordal Strain: Fluid-Structure Interaction Simulations. In Biology (Vol. 9, Issue 7, p. 173). MDPI AG. <a href="https://doi.org/10.3390/biology9070173">https://doi.org/10.3390/biology9070173</a></span> Biomarker MicroRNA Mild traumatic brain injury Saliva Sports-related concussion https://repository.nyitlibrary.org/files/original/e9b15442736432b2304a1d23eaac5f32.pdf e7573e7b0b812416d1a2aee80ae6ef02 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource NYITCOM - Faculty Publications Publication Book or Journal Article published by New York Tech Facility. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Attenuated evolution of mammals through the Cenozoic Identifier An unambiguous reference to the resource within a given context https://repository.nyitlibrary.org/files/original/e9b15442736432b2304a1d23eaac5f32.pdf <br /><a href="https://doi.org/10.1126/science.abm7525">https://doi.org/10.1126/science.abm7525</a> Creator An entity primarily responsible for making the resource Goswami, A., Noirault, E., Coombs, E. J., Clavel, J., Fabre, A.-C., Halliday, T. J. D., Churchill, M., Curtis, A., Watanabe, A., Simmons, N. B., Beatty, B. L., Geisler, J. H., Fox, D. L., & Felice, R. N. Date A point or period of time associated with an event in the lifecycle of the resource 2022 Subject The topic of the resource Animals Biological Evolution Eutheria anatomy & histology Female Fossils Index Medicus Phylogeny Rodentia Skull anatomy & histology Language A language of the resource English Abstract A summary of the resource. The Cenozoic diversification of placental mammals is the archetypal adaptive radiation. Yet, discrepancies between molecular divergence estimates and the fossil record fuel ongoing debate around the timing, tempo, and drivers of this radiation. Analysis of a three-dimensional skull dataset for living and extinct placental mammals demonstrates that evolutionary rates peak early and attenuate quickly. This long-term decline in tempo is punctuated by bursts of innovation that decreased in amplitude over the past 66 million years. Social, precocial, aquatic, and herbivorous species evolve fastest, especially whales, elephants, sirenians, and extinct ungulates. Slow rates in rodents and bats indicate dissociation of taxonomic and morphological diversification. Frustratingly, highly similar ancestral shape estimates for placental mammal superorders suggest that their earliest representatives may continue to elude unequivocal identification. Source A related resource from which the described resource is derived <em>Science</em>, Volume 378, Issue 6618, October 2022, pages 377-383 Format The file format, physical medium, or dimensions of the resource PDF Publisher An entity responsible for making the resource available American Association for the Advancement of Science (AAAS) Rights Information about rights held in and over the resource <span>Copyright © 2022 the authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original US government works. </span><a href="https://www.science.org/content/page/science-licenses-journal-article-reuse?adobe_mc=MCMID%3D20966568074372452772299603847900596611%7CMCORGID%3D242B6472541199F70A4C98A6%2540AdobeOrg%7CTS%3D1700174153">https://www.science.org/about/science-licenses-journal-article-reuse</a> Type The nature or genre of the resource Text Bibliographic Citation A bibliographic reference for the resource. Recommended practice is to include sufficient bibliographic detail to identify the resource as unambiguously as possible. <span>Goswami, A., Noirault, E., Coombs, E. J., Clavel, J., Fabre, A.-C., Halliday, T. J. D., Churchill, M., Curtis, A., Watanabe, A., Simmons, N. B., Beatty, B. L., Geisler, J. H., Fox, D. L., &amp; Felice, R. N. (2022). Attenuated evolution of mammals through the Cenozoic. In Science (Vol. 378, Issue 6618, pp. 377–383). American Association for the Advancement of Science (AAAS). <a href="https://doi.org/10.1126/science.abm7525">https://doi.org/10.1126/science.abm7525</a></span> adaptive radiation anatomy and histology animal animal experiment Animals article Biological Evolution Cenozoic Cetacea dissociation divergence elephant Eutheria evolution evolutionary rate female fossil fossil record Fossils herbivore innovation mammal Mammals nonhuman Phylogeny placenta placental mammal precocial species pregnancy rodent Rodentia skull ungulate https://repository.nyitlibrary.org/files/original/e7c1d7fa21cd93963587bdf5cd3aa8b3.pdf 4f3d0dde9318021ae04aacb84c8f1e28 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource NYITCOM - Faculty Publications Publication Book or Journal Article published by New York Tech Facility. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource DNA polymerase delta interacting protein 3 facilitates the activation and maintenance of DNA damage checkpoint in response to replication stress Identifier An unambiguous reference to the resource within a given context https://repository.nyitlibrary.org/files/original/e9b15442736432b2304a1d23eaac5f32.pdf <a href="https://doi.org/10.1002/ame2.12274">https://doi.org/10.1002/ame2.12274</a> Abstract A summary of the resource. <h4 class="article-section__sub-title section1">Background</h4> <p>Replication stress response is crucial for the maintenance of a stable genome. POLDIP3 (DNA polymerase delta interacting protein 3) was initially identified as one of the DNA polymerase δ (Pol δ) interacting proteins almost 20 years ago. Using a variety of in vitro biochemical assays, we previously established that POLDIP3 is a key regulator of the enzymatic activity of Pol δ. However, the in vivo function of POLDIP3 in DNA replication and DNA damage response has been elusive.</p> <h4 class="article-section__sub-title section1">Methods</h4> <p>We first generated POLDIP3 knockout (KO) cells using the CRISPR/Cas9 technology. We then investigated its biological functions in vivo using a variety of biochemical and cell biology assays.</p> <h4 class="article-section__sub-title section1">Results</h4> <p>We showed that although the POLDIP3-KO cells manifest no pronounced defect in global DNA synthesis under nonstress conditions, they are sensitive to a variety of replication fork blockers. Intriguingly, we found that POLDIP3 plays a crucial role in the activation and maintenance of the DNA damage checkpoint in response to exogenous as well as endogenous replication stress.</p> <h4 class="article-section__sub-title section1">Conclusion</h4> <p>Our results indicate that when the DNA replication fork is blocked, POLDIP3 can be recruited to the stalled replication fork and functions to bridge the early DNA damage checkpoint response and the later replication fork repair/restart.</p> Creator An entity primarily responsible for making the resource Zhang, S., Lee, E. Y. C., Lee, M. Y. W. T., & Zhang, D. Date A point or period of time associated with an event in the lifecycle of the resource 2022 Subject The topic of the resource DNA Damage DNA Polymerase III metabolism DNA Replication DNA damage checkpoint DNA polymerase delta Index Medicus POLDIP3 Replication stress Language A language of the resource English Source A related resource from which the described resource is derived <em>Animal Models and Experimental Medicine</em>, Volume 5, Issue 5, September 2022, pages 461-469 Publisher An entity responsible for making the resource available Wiley Rights Information about rights held in and over the resource <p class="copyright">© 2022 The Authors.<span> </span><i>Animal Models and Experimental Medicine</i><span> </span>published by John Wiley &amp; Sons Australia, Ltd on behalf of The Chinese Association for Laboratory Animal Sciences.</p> <p>This is an open access article under the terms of the<span> </span><a target="_blank" title="Link to external resource" href="http://creativecommons.org/licenses/by-nc-nd/4.0/" rel="noreferrer noopener">Creative Commons Attribution-NonCommercial-NoDerivs</a><span> </span>License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.</p> Bibliographic Citation A bibliographic reference for the resource. Recommended practice is to include sufficient bibliographic detail to identify the resource as unambiguously as possible. <span>Zhang, S., Lee, E. Y. C., Lee, M. Y. W. T., &amp; Zhang, D. (2022). &lt;scp&gt;DNA&lt;/scp&gt; polymerase delta interacting protein 3 facilitates the activation and maintenance of &lt;scp&gt;DNA&lt;/scp&gt; damage checkpoint in response to replication stress. In Animal Models and Experimental Medicine (Vol. 5, Issue 5, pp. 461–469). Wiley. <a href="https://doi.org/10.1002/ame2.12274">https://doi.org/10.1002/ame2.12274</a></span> DNA damage checkpoint DNA polymerase delta POLDIP3 replication stress https://repository.nyitlibrary.org/files/original/84a2cdb5eb7d2449b20b2d80e4aaedb0.pdf d75cee8777755b84da5a0ee11af86838 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource NYITCOM - Faculty Publications Publication Book or Journal Article published by New York Tech Facility. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Computational Biology: A New Frontier in Applied Biology Identifier An unambiguous reference to the resource within a given context https://repository.nyitlibrary.org/files/original/84a2cdb5eb7d2449b20b2d80e4aaedb0.pdf <a href="https://doi.org/10.3390/biology10050374">https://doi.org/10.3390/biology10050374</a> Creator An entity primarily responsible for making the resource Toma, M. & Concu, R. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Publisher An entity responsible for making the resource available MDPI AG Subject The topic of the resource Biology Computational Biology Language A language of the resource English Source A related resource from which the described resource is derived MDPI <em>Biology</em>, Volume 10, Issue 5, April 2021, Article 374 Rights Information about rights held in and over the resource <span>© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (</span><a href="https://creativecommons.org/licenses/by/4.0/" target="_blank" rel="noreferrer noopener">https://creativecommons.org/licenses/by/4.0/</a><span>).</span> Format The file format, physical medium, or dimensions of the resource PDF Type The nature or genre of the resource Text Bibliographic Citation A bibliographic reference for the resource. Recommended practice is to include sufficient bibliographic detail to identify the resource as unambiguously as possible. <span>Toma, M., &amp; Concu, R. (2021). Computational Biology: A New Frontier in Applied Biology. In Biology (Vol. 10, Issue 5, p. 374). MDPI AG. <a href="https://doi.org/10.3390/biology10050374">https://doi.org/10.3390/biology10050374</a></span> biology computational biology https://repository.nyitlibrary.org/files/original/5a126b18dce9e48bf5f1789d34af0825.pdf ca410c7b42bef5c7e4a0c1aab3a15013 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource NYITCOM - Faculty Publications Publication Book or Journal Article published by New York Tech Facility. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource AMPK promotes the survival of colorectal cancer stem cells Identifier An unambiguous reference to the resource within a given context https://repository.nyitlibrary.org/files/original/5a126b18dce9e48bf5f1789d34af0825.pdf <a href="https://doi.org/10.3390/biology10050374">https://doi.org/10.3390/biology10050374</a> Creator An entity primarily responsible for making the resource Guo, B., Han, X., Tkach, D., Huang, S., & Zhang, D. Date A point or period of time associated with an event in the lifecycle of the resource 2018 Publisher An entity responsible for making the resource available Wiley Subject The topic of the resource AMP‐activated protein kinase Cancer metabolism Colorectal cancer stem cells Patient‐derived xenograft Language A language of the resource English Abstract A summary of the resource. Background Colorectal cancer (CRC) is the third most commonly diagnosed cancer in males and the second in females worldwide in 2012. In the past 20 years, strong evidence suggests that cancer stem cells are the main culprit of cancer metastasis, chemotherapy resistance, and relapse. Methods To further understand the unique biological properties of cancer stem cells and uncover novel molecular targets to eradicate them, we first established a panel of patient-derived xenograft (PDX) tumor models using tumors surgically removed from human colorectal cancer patients. We then isolated CRC cancer stem cells based on their ALDH activity using fluorescent-activated cell sorting (FACS) and characterized their metabolic properties. Results Interestingly, we found that the CRC cancer stem cells (ie, CRC cells with higher ALDH activity, or ALDH+) express higher level of antioxidant genes and have lower level of reactive oxygen species (ROS) than non-CRC cancer stem cells (ie, CRC cells with lower ALDH activity, or ALDH−). The CRC cancer stem cells also possess more mitochondria mass and show higher mitochondrial activity. More intriguingly, we observed higher AMP-activated protein kinase (AMPK) activities in these CRC cancer stem cells. Inhibition of the AMPK activity using 2 AMPK inhibitors, Compound C and Iodotubercidin, preferentially induces cell death in CRC cancer stem cells. Conclusion We propose that AMPK inhibitors may help to eradicate the CRC cancer stem cells and prevent the relapse of CRCs. Source A related resource from which the described resource is derived <em>Animal Models and Experimental Medicine</em>, Volume 1, Issue 2, July 2018, pages 134-142 Rights Information about rights held in and over the resource CC BY-NC 4.0 DEED Attribution-NonCommercial 4.0 International Format The file format, physical medium, or dimensions of the resource PDF Type The nature or genre of the resource Text Bibliographic Citation A bibliographic reference for the resource. Recommended practice is to include sufficient bibliographic detail to identify the resource as unambiguously as possible. <span>Guo, B., Han, X., Tkach, D., Huang, S., &amp; Zhang, D. (2018). AMPK promotes the survival of colorectal cancer stem cells. In Animal Models and Experimental Medicine (Vol. 1, Issue 2, pp. 134–142). Wiley. <a href="https://doi.org/10.1002/ame2.12016">https://doi.org/10.1002/ame2.12016</a></span> https://repository.nyitlibrary.org/files/original/10246d4cd7af85b033434643ee012c81.pdf bba5911609e29273eaf9ba0fdfe724a5 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource NYITCOM - Faculty Publications Publication Book or Journal Article published by New York Tech Facility. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource A comparative study of the effectiveness of an osteopathic primary care sports medicine led intervention on performance in men’s collegiate lacrosse players Identifier An unambiguous reference to the resource within a given context https://repository.nyitlibrary.org/files/original/5a126b18dce9e48bf5f1789d34af0825.pdf <a href="https://doi.org/10.1515/jom-2021-0083">https://doi.org/10.1515/jom-2021-0083</a> Creator An entity primarily responsible for making the resource Rao, N. C., Zwibel, H., Berezanskaya, J., Pena, P., & Jung, M.-K. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Publisher An entity responsible for making the resource available Walter de Gruyter GmbH Subject The topic of the resource Collegiate sports Family medicine Health; lacrosse Osteopathic medicine Performance Primary care Sports medicine Language A language of the resource English Abstract A summary of the resource. <p><strong class="sub-title">Context:<span> </span></strong>Comprehensive sports medicine care goes beyond the treatment of injuries resulting from athletic activities. Ultimately, it is a competence that includes knowledge in physical therapy, training, nutrition, coaching, motivation, competition, mentoring, psychology, and spirituality that allows the physician and patient to collaborate on promoting the patient's health goals. The current literature demonstrates a lack of knowledge in the Osteopathic Primary Care Sports Medicine Model's effectiveness in performance.</p> <p><strong class="sub-title">Objectives:<span> </span></strong>To determine whether a comprehensive osteopathic primary care sports medicine approach can improve performance and health outcomes in collegiate athletes.</p> <p><strong class="sub-title">Methods:<span> </span></strong>A randomized controlled trial commenced just prior to the start of the lacrosse season and concluded at the end of the season. All the New York Institute of Technology (NYIT) collegiate lacrosse players were educated first in a 1-day seminar of the core competencies, and all participants had access to ask questions on their own volition. Then they were randomized into two groups, either the experimental group receiving the direct osteopathic primary care sports medicine intervention (n=18) or the control group not having active intervention (n=19). Also, the overall team winning percentage for that season was computed and compared to that for the previous years and the following year. Participants were assessed before and after the intervention with the Patient Health Questionnaire (PHQ-9), the 36-Item Short Form Survey (SF-36), custom Osteopathic Primary Care Sports Medicine questionnaire, and body fat composition, and their changes were compared between the experimental group and the control group. Collected data were analyzed using the repeated-measures analysis of variance.</p> <p><strong class="sub-title">Results:<span> </span></strong>Thirty-seven participants were enrolled in the study. After 14 participants were excluded due to being lost to follow-up, 23 athlete records were analyzed. The winning percentage of the team was highest during the year of the study period time than in the 3 previous years and the following year. The test group did not have any statistically significant change in the PHQ-9, SF-36, custom Osteopathic Primary Care Sports Medicine questionnaire, as well as in body fat composition.</p> <p><strong class="sub-title">Conclusions:<span> </span></strong>When used during a collegiate lacrosse season, this Osteopathic Primary Care Sports Medicine intervention did not significantly improve health outcomes. This preliminary study, despite its limitations in compliance and study population size, did demonstrate improvement in overall team performance when comparing the intervention sport season to other seasons but was not statistically significantly. Therefore, further studies are warranted to improve the understanding in this approach to athlete health outcomes and performance.</p> Source A related resource from which the described resource is derived <em>Journal of Osteopathic Medicine</em>, Volume 122, Issue 2, November 2021, pages 71-77 Rights Information about rights held in and over the resource CC BY 4.0 DEED Attribution 4.0 International © 2021 Naresh C. Rao et al., published by De Gruyter, Berlin/Boston. Format The file format, physical medium, or dimensions of the resource PDF Type The nature or genre of the resource Text Bibliographic Citation A bibliographic reference for the resource. Recommended practice is to include sufficient bibliographic detail to identify the resource as unambiguously as possible. <span>Rao, N. C., Zwibel, H., Berezanskaya, J., Pena, P., &amp; Jung, M.-K. (2021). A comparative study of the effectiveness of an osteopathic primary care sports medicine led intervention on performance in men’s collegiate lacrosse players. In Journal of Osteopathic Medicine (Vol. 122, Issue 2, pp. 71–77). Walter de Gruyter GmbH. <a href="https://doi.org/10.1515/jom-2021-0083">https://doi.org/10.1515/jom-2021-0083</a></span> https://repository.nyitlibrary.org/files/original/6e794861ca8dc1809b7ddf8fedc66c68.pdf 7d8b285160766f470ec175a68ce1c286 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource NYITCOM - Faculty Publications Publication Book or Journal Article published by New York Tech Facility. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Novel beta-blocker pretreatment prevents alcohol-induced atrial fibrillation in a rat model Identifier An unambiguous reference to the resource within a given context https://repository.nyitlibrary.org/files/original/6e794861ca8dc1809b7ddf8fedc66c68.pdf <a href="https://doi.org/10.1016/j.hroo.2020.02.006">https://doi.org/10.1016/j.hroo.2020.02.006</a> Creator An entity primarily responsible for making the resource Hassan, H., Greco, L. V., Meshoyrer, D. I., Li, Y., Zhang, Y., & Cohen, T. J. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Publisher An entity responsible for making the resource available Elsevier BV Subject The topic of the resource Alcohol Atrial fibrillation Atrial fibrillation inducibility Beta-blocker Effective refractory period Language A language of the resource English Abstract A summary of the resource. <div class="sec sec-first"> <h3>Background</h3> <p class="p p-first-last">A case report published in 2019 described a patient who presented with difficult-to-manage atrial fibrillation (AF) that consistently was associated with alcohol consumption. After the patient did not respond to drug therapy, a novel beta-blocker (BB) pretreatment regimen initiated immediately before alcohol consumption successfully prevented AF occurrence.</p> </div> <div class="sec"> <h3>Objective</h3> <p class="p p-first-last">The purpose of this study was to test the hypothesis that a novel prophylactic BB therapy given before alcohol consumption could prevent AF in a rat model.</p> </div> <div class="sec"> <h3>Methods</h3> <p class="p p-first-last">An alcohol-induced AF model was developed in adult Sprague-Dawley rats of both sexes by administering alcohol (2 g/kg intraperitoneal [IP]) once every other day for a total of 4 times. Three groups were enrolled: alcohol (EtOH; n = 10); alcohol plus BB (metoprolol 50 mg/kg IP) pretreatment (EtOH+BB; n = 10); and control (n = 9). Cardiac function (assessed by echocardiography and left ventricular hemodynamics) and<span> </span><em>in vivo</em><span> </span>atrial electrophysiology and AF inducibility tests were performed 24 hours after the last injection.</p> </div> <div class="sec"> <h3>Results</h3> <p class="p p-first-last">All but 1 rat completed the study. Alcohol exposure did not significantly impact cardiac function and the atrial effective refractory period. However, alcohol exposure significantly increased AF inducibility [median (first and third quartile [Q1–Q3]) 0% (0%–0%) in control vs 60% (25%–100%) in the EtOH group;<span> </span><em>P</em> &lt;.05] and AF duration [0 second (0–0 second) in control vs 0.81 second (0.24–3.67 seconds) in the EtOH group;<span> </span><em>P</em><span> </span>&lt;.05]. Compared to the EtOH group, the EtOH+BB group had significantly reduced AF inducibility [0% (0%–22.5%);<span> </span><em>P</em><span> </span>&lt;.05] and duration [0 second (0–0.2 second);<span> </span><em>P</em><span> </span>&lt;.05].</p> </div> <div class="sec sec-last"> <h3>Conclusion</h3> <p class="p p-first-last">Metoprolol pretreatment before alcohol administration significantly decreased AF induction in rats. These findings suggest that BB pretreatment is a promising prophylaxis regimen for alcohol-induced AF.</p> </div> Source A related resource from which the described resource is derived <em>Heart Rhythm O2</em>, Volume 2, Issue 1, February 2021, Pages 111-112 Rights Information about rights held in and over the resource CC BY-NC-ND 4.0 DEED Attribution-NonCommercial-NoDerivs 4.0 International Format The file format, physical medium, or dimensions of the resource PDF Type The nature or genre of the resource Text Bibliographic Citation A bibliographic reference for the resource. Recommended practice is to include sufficient bibliographic detail to identify the resource as unambiguously as possible. Hassan, H., Greco, L. V., Meshoyrer, D. I., Li, Y., Zhang, Y., &amp; Cohen, T. J. (2020). Novel beta-blocker pretreatment prevents alcohol-induced atrial fibrillation in a rat model. In Heart Rhythm O2 (Vol. 1, Issue 2, pp. 120–125). Elsevier BV. <a href="https://doi.org/10.1016/j.hroo.2020.02.006">https://doi.org/10.1016/j.hroo.2020.02.006</a> https://repository.nyitlibrary.org/files/original/98594e6494575fa46ec0169bb37923f1.pdf b970c1a5a540a20e67a7273c8b4c97d2 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource NYITCOM - Faculty Publications Publication Book or Journal Article published by New York Tech Facility. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Chronic dantrolene treatment attenuates cardiac dysfunction and reduces atrial fibrillation inducibility in a rat myocardial infarction heart failure model Identifier An unambiguous reference to the resource within a given context https://repository.nyitlibrary.org/files/original/98594e6494575fa46ec0169bb37923f1.pdf <a href="https://doi.org/10.1016/j.hroo.2020.03.004">https://doi.org/10.1016/j.hroo.2020.03.004</a> Date A point or period of time associated with an event in the lifecycle of the resource 2020 Publisher An entity responsible for making the resource available Elsevier BV Subject The topic of the resource Atrial fibrillation Cardiac ryanodine receptor Dantrolene Heart failure Ryanodine receptor stabilizer Language A language of the resource English Abstract A summary of the resource. <div class="sec sec-first"> <h3>Background</h3> <p class="p p-first-last">Cardiac ryanodine receptor 2 (RyR2) dysfunction and elevated diastolic Ca²⁺<span> </span>leak have been linked to arrhythmogenesis not only in inherited arrhythmia syndromes but also in acquired forms of heart disease including heart failure (HF) and atrial fibrillation (AF). Thus, stabilizing RyR2 may exert therapeutic effects in these conditions.</p> </div> <div class="sec"> <h3>Objective</h3> <p class="p p-first-last">The purpose of this study was to investigate the effects of stabilizing RyR2 with chronic dantrolene treatment on HF development and AF inducibility in a myocardial infarction (MI)–induced HF model in rats.</p> </div> <div class="sec"> <h3>Methods</h3> <p class="p p-first-last">MI was induced in adult Sprague-Dawley rats by ligation of the left anterior descending coronary artery. Two weeks after MI surgery, rats with large MI (≥40%) were randomly assigned to MI-vehicle (n = 14) or MI-dantrolene (10 mg/kg/d; n = 13) groups. Sham-surgery rats (n = 7) served as controls.</p> </div> <div class="sec"> <h3>Results</h3> <p class="p p-first-last">Compared to the MI-vehicle group, 4-week dantrolene treatment significantly improved cardiac function, with increased left ventricular (LV) fractional shortening (19.48% ± 3.61% vs 15.43% ± 2.65%;<span> </span><em>P</em><span> </span>&lt;.01), and decreased LV end-diastolic pressure (12.58 ± 8.52 mm Hg vs 21.91 ± 7.25 mm Hg;<span> </span><em>P</em><span> </span>&lt;.01), left atrial diameter (4.97 ± 0.75 mm vs 6.09 ± 1.53 mm;<span> </span><em>P</em><span> </span>&lt;.05), and fibrosis content (6.42% ± 0.78% vs 9.76% ± 2.25%;<span> </span><em>P</em><span> </span>&lt;.001). Dantrolene significantly decreased AF inducibility (69% in MI-vehicle vs 23% in MI-dantrolene;<span> </span><em>P</em><span> </span>&lt;.05). Dantrolene treatment was associated with reduced RyR2 phosphorylation and favorably altered gene expression involving ion channels, sympathetic signaling, oxidative stress, and inflammatory markers.</p> </div> <div class="sec sec-last"> <h3>Conclusion</h3> <p class="p p-first-last">Chronic dantrolene treatment attenuated LV dysfunction and reduced AF inducibility, which was associated with decreased RyR2 phosphorylation and normalization of many adverse changes in gene expression. Thus, stabilizing RyR2 with chronic dantrolene treatment is a promising novel strategy for decreasing AF in HF.</p> </div> Source A related resource from which the described resource is derived <em>Heart Rhythm O2</em>, Volume 2, Issue 1, February 2021, Pages 111-112 Rights Information about rights held in and over the resource CC BY-NC-ND 4.0 DEED Attribution-NonCommercial-NoDerivs 4.0 International Format The file format, physical medium, or dimensions of the resource PDF Type The nature or genre of the resource Text Bibliographic Citation A bibliographic reference for the resource. Recommended practice is to include sufficient bibliographic detail to identify the resource as unambiguously as possible. Nofi, C., Zhang, K., Tang, Y.-D., Li, Y., Migirov, A., Ojamaa, K., Gerdes, A. M., &amp; Zhang, Y. (2020). Chronic dantrolene treatment attenuates cardiac dysfunction and reduces atrial fibrillation inducibility in a rat myocardial infarction heart failure model. In Heart Rhythm O2 (Vol. 1, Issue 2, pp. 126–135). Elsevier BV. <a href="https://doi.org/10.1016/j.hroo.2020.03.004">https://doi.org/10.1016/j.hroo.2020.03.004</a> Creator An entity primarily responsible for making the resource Nofi, C., Zhang, K., Tang, Y.-D., Li, Y., Migirov, A., Ojamaa, K., Gerdes, A. M., & Zhang, Y. https://repository.nyitlibrary.org/files/original/799371860b31fbd59d1b16acddf4de08.pdf 5f401029a1663f51c31eecdea29bd040 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource NYITCOM - Faculty Publications Publication Book or Journal Article published by New York Tech Facility. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Triiodothyronine maintains cardiac transverse-tubule structure and function Identifier An unambiguous reference to the resource within a given context https://repository.nyitlibrary.org/files/original/799371860b31fbd59d1b16acddf4de08.pdf <a href="https://doi.org/10.1016/j.yjmcc.2021.06.010">https://doi.org/10.1016/j.yjmcc.2021.06.010</a> Creator An entity primarily responsible for making the resource Gilani, N., Wang, K., Muncan, A., Peter, J., An, S., Bhatti, S., Pandya, K., Zhang, Y., Tang, Y.-D., Gerdes, A. M., Stout, R. F., & Ojamaa, K. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Publisher An entity responsible for making the resource available Elsevier BV Subject The topic of the resource Ca(2+) Calcium Junctophilin-2 Ryanodine receptors STORM Thyroid hormone Transverse-tubules Language A language of the resource English Abstract A summary of the resource. <span>Subclinical hypothyroidism and low T3 syndrome are commonly associated with an increased risk of cardiovascular disease (CVD) and mortality. We examined effects of T3 on T-tubule (TT) structures, Ca</span>²⁺<span> mobilization and contractility, and clustering of dyadic proteins. Thyroid hormone (TH) deficiency was induced in adult female rats by propyl-thiouracil (PTU; 0.025%) treatment for 8 weeks. Rats were then randomized to continued PTU or triiodo-L-thyronine (T3; 10 μg/kg/d) treatment for 2 weeks (PTU + T3). After in vivo echocardiographic and hemodynamic recordings, cardiomyocytes (CM) were isolated to record Ca</span>²⁺<span> transients and contractility. TT organization was assessed by confocal microscopy, and STORM images were captured to measure ryanodine receptor (RyR2) cluster number and size, and L-type Ca</span>²⁺<span> channel (LTCC, Ca</span>_v<span>1.2) co-localization. Expressed genes including two integral TT proteins, junctophilin-2 (Jph-2) and bridging integrator-1 (BIN1), were analyzed in left ventricular (LV) tissues and cultured CM using qPCR and RNA sequencing. The T3 dosage used normalized serum T3, and reversed adverse effects of TH deficiency on in vivo measures of cardiac function. Recordings of isolated CM indicated that T3 increased rates of Ca</span>²⁺<span> release and re-uptake, resulting in increased velocities of sarcomere shortening and re-lengthening. TT periodicity was significantly decreased, with reduced transverse tubules but increased longitudinal tubules in TH-deficient CMs and LV tissue, and these structures were normalized by T3 treatment. Analysis of STORM data of PTU myocytes showed decreased RyR2 cluster numbers and RyR localizations within each cluster without significant changes in Ca</span>_v<span>1.2 localizations within RyR clusters. T3 treatment normalized RyR2 cluster size and number. qPCR and RNAseq analyses of LV and cultured CM showed that Jph2 expression was T3-responsive, and its increase with treatment may explain improved TT organization and RyR-LTCC coupling.</span> Source A related resource from which the described resource is derived <em>Journal of Molecular and Cellular Cardiology</em>, Volume 160, November 2021, Pages 1-14 Rights Information about rights held in and over the resource CC BY-NC-ND 4.0 DEED Attribution-NonCommercial-NoDerivs 4.0 International. Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved. Format The file format, physical medium, or dimensions of the resource PDF Type The nature or genre of the resource Text Bibliographic Citation A bibliographic reference for the resource. Recommended practice is to include sufficient bibliographic detail to identify the resource as unambiguously as possible. <span>Gilani, N., Wang, K., Muncan, A., Peter, J., An, S., Bhatti, S., Pandya, K., Zhang, Y., Tang, Y.-D., Gerdes, A. M., Stout, R. F., &amp; Ojamaa, K. (2021). Triiodothyronine maintains cardiac transverse-tubule structure and function. In Journal of Molecular and Cellular Cardiology (Vol. 160, pp. 1–14). Elsevier BV. <a href="https://doi.org/10.1016/j.yjmcc.2021.06.010">https://doi.org/10.1016/j.yjmcc.2021.06.010</a></span> https://repository.nyitlibrary.org/files/original/350f93901e031e7088e653bb9904b6b9.pdf 424748c8a252e1bacc99dc00a1b7c851 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource NYITCOM - Faculty Publications Publication Book or Journal Article published by New York Tech Facility. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Is step width decoupled from pelvic motion in human evolution? Identifier An unambiguous reference to the resource within a given context https://repository.nyitlibrary.org/files/original/350f93901e031e7088e653bb9904b6b9.pdf <a href="https://doi.org/10.1038/s41598-020-64799-3">https://doi.org/10.1038/s41598-020-64799-3</a> Creator An entity primarily responsible for making the resource Kikel, M., Gecelter, R., & Thompson, N. E. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Publisher An entity responsible for making the resource available Springer Science and Business Media LLC Language A language of the resource English Abstract A summary of the resource. Humans are the only primate that walk bipedally with adducted hips, valgus knees, and swing-side pelvic drop. These characteristic frontal-plane aspects of bipedalism likely play a role in balance and energy minimization during walking. Understanding when and why these aspects of bipedalism evolved also requires an understanding of how each of these features are interrelated during walking. Here we investigated the relationship between step width, hip adduction, and pelvic list during bipedalism by altering step widths and pelvic motions in humans in ways that both mimic chimpanzee gait as well as an exaggerated human gait. Our results show that altering either step width or pelvic list to mimic those of chimpanzees affects hip adduction, but neither of these gait parameters dramatically affects the other in ways that lead to a chimpanzee-like gait. These results suggest that the evolution of valgus knees and narrow steps in humans may be decoupled from the evolution of the human-like pattern of pelvic list. While the origin of narrow steps in hominins may be linked to minimizing energetic cost of locomotion, the origin of the human-like pattern of pelvic list remains unresolved. Subject The topic of the resource Animals Biological Evolution Gait Hip Humans Knee Pelvic Bones Postural Balance Primates Walking Source A related resource from which the described resource is derived <em>Scientific Reports</em>, Volume 10, Issue 1, May 2020 Rights Information about rights held in and over the resource Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, <a href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</a> Format The file format, physical medium, or dimensions of the resource PDF Type The nature or genre of the resource Text Bibliographic Citation A bibliographic reference for the resource. Recommended practice is to include sufficient bibliographic detail to identify the resource as unambiguously as possible. <span>Kikel, M., Gecelter, R., &amp; Thompson, N. E. (2020). Is step width decoupled from pelvic motion in human evolution? In Scientific Reports (Vol. 10, Issue 1). Springer Science and Business Media LLC. <a href="https://doi.org/10.1038/s41598-020-64799-3">https://doi.org/10.1038/s41598-020-64799-3</a></span>