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                <text>&lt;p class="mb15"&gt;&lt;b&gt;Background:&lt;/b&gt;&lt;span&gt; &lt;/span&gt;Cardiac re-expression of fetal genes in patients with heart failure (HF) suggests the presence of low cardiac tissue thyroid hormone (TH) function. However, serum concentrations of T3 and T4 are often normal or subclinically low, necessitating an alternative serum biomarker for low cardiac TH function to guide treatment of these patients. The clinical literature suggests that serum Brain Natriuretic Peptide (BNP) levels are inversely associated with serum triiodo-L-thyronine (T3) levels. The objective of this study was to investigate BNP as a potential serum biomarker for TH function in the heart.&lt;/p&gt;
&lt;p class="mb15"&gt;&lt;b&gt;Methods:&lt;/b&gt;&lt;span&gt; &lt;/span&gt;Two animal models of thyroid hormone deficiency: (1) 8-weeks of propyl thiouracil-induced hypothyroidism (Hypo) in adult female rats were subsequently treated with oral T3 (10 μg/kg/d) for 3, 6, or 14 days; (2) HF induced by coronary artery ligation (myocardial infarction, MI) in adult female rats was treated daily with low dose oral T3 (5 μg/kg/d) for 8 or 16 wks.&lt;/p&gt;
&lt;p class="mb15"&gt;&lt;b&gt;Results:&lt;/b&gt;&lt;span&gt; &lt;/span&gt;Six days of T3 treatment of Hypo rats normalized most cardiac functional parameters. Serum levels of BNP increased 5-fold in Hypo rats, while T3 treatment normalized BNP by day 14, showing a significant inverse relationship between serum BNP and free or total T3 concentrations. Myocardial BNP mRNA was increased 2.5-fold in Hypo rats and its expression was decreased to normal values by 14 days of T3 treatment. Measurements of hemodynamic function showed significant dysfunction in MI rats after 16 weeks, with serum BNP increased by 4.5-fold and serum free and total T3 decreased significantly. Treatment with T3 decreased serum BNP while increasing total T3 indicating an inverse correlation between these two biologic factors (&lt;i&gt;r&lt;/i&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;span&gt; &lt;/span&gt;= 0.676,&lt;span&gt; &lt;/span&gt;&lt;i&gt;p&lt;/i&gt;&lt;span&gt; &lt;/span&gt;&amp;lt; 0.001). Myocardial BNP mRNA was increased 5-fold in MI rats which was significantly decreased by T3 over 8 to 16 week treatment periods.&lt;/p&gt;
&lt;p class="mb0"&gt;&lt;b&gt;Conclusions:&lt;/b&gt;&lt;span&gt; &lt;/span&gt;Results from the two models of TH dysfunction confirmed an inverse relationship between tissue and serum T3 and BNP, such that the reduction in serum BNP could potentially be utilized to monitor efficacy and dosing of T3 treatment. Thus, serum BNP may serve as a reliable biomarker for cardiac TH function.&lt;/p&gt;</text>
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&lt;p&gt;&lt;strong&gt;Objective&lt;/strong&gt;&lt;span&gt; &lt;/span&gt;The effect of prolonged sitting on executive function and performance in competitive esports players are unknown. This study aimed to evaluate executive function following a 6 min bout of walking or rest during prolonged gaming in competitive esports players.&lt;/p&gt;
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&lt;p&gt;&lt;strong&gt;Methods&lt;/strong&gt;&lt;span&gt; &lt;/span&gt;12 men and 9 women completed three separate 2-hour gaming session days assigned in randomised order consisting of a 6 min walk break, 6 min rest break and continuous before and after each session. Postintervention participant exit survey data were also collected.&lt;/p&gt;
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&lt;p&gt;&lt;strong&gt;Results&lt;/strong&gt;&lt;span&gt; &lt;/span&gt;The walk condition produced a significantly faster mean solution time (7613.6±3060.5 min, p=0.02) and planning time (5369.0±2802.09, p=0.04) compared with the resting condition (9477±3547.4; 6924±3247.7) and continuous play (8200.0±3031.6; 5862.7±2860.7). The rest condition resulted in the slowest mean solution time (9477.0±3547.4) and planning time (6924.0±3247.7), with the continuous play resulting in a faster mean solution time (8200.1±3031.6) and planning time (5862.7±2860.7) than the rest condition. There was no impact on game performance in any of the conditions. However, over 70% of participants felt that the walk break improved esports performance.&lt;/p&gt;
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&lt;p&gt;&lt;strong&gt;Conclusions&lt;/strong&gt;&lt;span&gt; &lt;/span&gt;Reducing sit time and breaking up prolonged sitting have acute and chronic health benefits. This study provides evidence that a 6 min walking break in the middle of 2 hours of gameplay allows gamers to have these health benefits while improving processing speed and executive function.&lt;/p&gt;
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&lt;p&gt;&lt;strong&gt;Trial registration number&lt;/strong&gt;&lt;span&gt; &lt;/span&gt;&lt;a class="external-ref external-ref-type-clintrialgov" href="https://bmjopensem.bmj.com/lookup/external-ref?link_type=CLINTRIALGOV&amp;amp;access_num=NCT04674436&amp;amp;atom=%2Fbmjosem%2F7%2F3%2Fe001118.atom"&gt;NCT04674436&lt;/a&gt;.&lt;/p&gt;
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>School of Engineering &amp; Computing Sciences</text>
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      <name>Thesis</name>
      <description>A long essay or dissertation involving personal research, written by a candidate for a college degree.</description>
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        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Bringing Power to the Rural Areas of Bangladesh Using Renewable Energy Technology</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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                <text>Hossain, Mohammed.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2012</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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                <text>New York Institute of Technology</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>Renewable energy sources--Bangladesh.&#13;
Energy development--Bangladesh.&#13;
Energy consumption--Bangladesh.</text>
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          <element elementId="44">
            <name>Language</name>
            <description>A language of the resource</description>
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                <text>English</text>
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            <name>Format</name>
            <description>The file format, physical medium, or dimensions of the resource</description>
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                <text>PDF</text>
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          <element elementId="51">
            <name>Type</name>
            <description>The nature or genre of the resource</description>
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                <text>Text</text>
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          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="23823">
                <text>&lt;a href="https://repository.nyitlibrary.org/files/original/f5baa63d6ff592721cc08b0b54fde650.pdf"&gt;https://repository.nyitlibrary.org/files/original/f5baa63d6ff592721cc08b0b54fde650.pdf&lt;/a&gt;</text>
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        <name>computer science</name>
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      <tag tagId="7">
        <name>Energy</name>
      </tag>
      <tag tagId="1">
        <name>Thesis</name>
      </tag>
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</itemContainer>
