80 20 3290 https://repository.nyitlibrary.org/files/original/f987e9eb92974a24372265e586d9589e.pdf 7ce1608e6738be2553d9aef963120125 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Business Administration - Dissertations & Theses Thesis A long essay or dissertation involving personal research, written by a candidate for a college degree. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Influence of Corporate Environment on Innovation Creator An entity primarily responsible for making the resource Chang, Pei K Date A point or period of time associated with an event in the lifecycle of the resource 1982 Publisher An entity responsible for making the resource available New York Institute of Technology Subject The topic of the resource Research, Industrial. Technological innovations. Language A language of the resource English Format The file format, physical medium, or dimensions of the resource PDF Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context <a href="https://repository.nyitlibrary.org/files/original/f987e9eb92974a24372265e586d9589e.pdf">https://repository.nyitlibrary.org/files/original/f987e9eb92974a24372265e586d9589e.pdf</a> Business Thesis https://repository.nyitlibrary.org/files/original/6bc15f814724519525d8a2fb083504b6.pdf e410f2faa0021b3b60411ef93d146e1a Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Business Administration Thesis A long essay or dissertation involving personal research, written by a candidate for a college degree. School School of Business Department Department of Business Administration Degree Master of Business Administration Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Information Flow and Control in Public Works Management : With Focus on Improved Documentation in Utilizing a Modern Management Information System Creator An entity primarily responsible for making the resource Sweetland, W. A. Date A point or period of time associated with an event in the lifecycle of the resource 1975 Publisher An entity responsible for making the resource available Old Westbury, N.Y. : New York Institute of Technology, 1981. Subject The topic of the resource Management information systems. Language A language of the resource English Format The file format, physical medium, or dimensions of the resource PDF Type The nature or genre of the resource Thesis (Master's)--New York Institute of Technology, 1975. Identifier An unambiguous reference to the resource within a given context https://repository.nyitlibrary.org/files/original/6bc15f814724519525d8a2fb083504b6.pdf Business Thesis https://repository.nyitlibrary.org/files/original/bfb34656c916eee3bcd6902a639e1220.pdf e02de1de8ae8ee59300cbaaca538f2ee Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Business Administration - Dissertations & Theses Thesis A long essay or dissertation involving personal research, written by a candidate for a college degree. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Information management : protecting the individual's privacy. Creator An entity primarily responsible for making the resource Picarelli, Alfred F. Date A point or period of time associated with an event in the lifecycle of the resource 1979 Publisher An entity responsible for making the resource available New York Institute of Technology Subject The topic of the resource Information resources management. Privacy. Language A language of the resource English Format The file format, physical medium, or dimensions of the resource PDF Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context https://repository.nyitlibrary.org/files/original/bfb34656c916eee3bcd6902a639e1220.pdf https://repository.nyitlibrary.org/files/original/a4cce1eba821e34ffb5949f64395bc46.pdf 5747b0f5f8e8f5f61afbca2d9b681543 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Business Administration - Dissertations & Theses Thesis A long essay or dissertation involving personal research, written by a candidate for a college degree. School School of Management Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Information Resources Management : Impact on Management Science Creator An entity primarily responsible for making the resource Gudsnuk, Joseph Date A point or period of time associated with an event in the lifecycle of the resource 1986 Publisher An entity responsible for making the resource available New York Institute of Technology Subject The topic of the resource Information resources management Language A language of the resource English Format The file format, physical medium, or dimensions of the resource PDF Type The nature or genre of the resource Thesis (M.S.)--New York Institute of Technology Identifier An unambiguous reference to the resource within a given context <a href="https://repository.nyitlibrary.org/files/original/a4cce1eba821e34ffb5949f64395bc46.pdf" target="_blank" title="Information Resources Management : Impact on Management Science" rel="noreferrer noopener">https://repository.nyitlibrary.org/files/original/a4cce1eba821e34ffb5949f64395bc46.pdf</a> Business Thesis https://repository.nyitlibrary.org/files/original/f74566b1afa3e7372aaf990f39b9cd75.pdf e04c64f844e2d4012df008d3cc9958f9 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Business Administration - Dissertations & Theses Thesis A long essay or dissertation involving personal research, written by a candidate for a college degree. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Information retrieval project Creator An entity primarily responsible for making the resource Watts, Walter F. Date A point or period of time associated with an event in the lifecycle of the resource 1973 Publisher An entity responsible for making the resource available New York Institute of Technology Language A language of the resource English Format The file format, physical medium, or dimensions of the resource PDF Type The nature or genre of the resource Text Subject The topic of the resource Database management. Information storage and retrieval systems. Identifier An unambiguous reference to the resource within a given context <a href="https://repository.nyitlibrary.org/files/original/f74566b1afa3e7372aaf990f39b9cd75.pdf">https://repository.nyitlibrary.org/files/original/f74566b1afa3e7372aaf990f39b9cd75.pdf</a> https://repository.nyitlibrary.org/files/original/d6ae440d29fd1019c5bd72ce82d09d53.pdf bd7e5f460588af4e70fc46d9ad82cfe0 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Business Administration - Dissertations & Theses Thesis A long essay or dissertation involving personal research, written by a candidate for a college degree. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Information technology : the impact on the workplace. Creator An entity primarily responsible for making the resource Scheingut, Yair. Date A point or period of time associated with an event in the lifecycle of the resource 1986 Publisher An entity responsible for making the resource available New York Institute of Technology Subject The topic of the resource Information storage and retrieval systems. Microelectronics--Social aspects. Language A language of the resource English Format The file format, physical medium, or dimensions of the resource PDF Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context https://repository.nyitlibrary.org/files/original/d6ae440d29fd1019c5bd72ce82d09d53.pdf https://repository.nyitlibrary.org/files/original/d0f38ea42222375f8057c73f75c790bb.pdf a30d5a6aaed0d2ce5c8c76bfdc68939c Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Energy Management - Dissertations & Theses Thesis A long essay or dissertation involving personal research, written by a candidate for a college degree. School School of Engineering and Technology Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Information Technology Applications in the Field of Energy Management Creator An entity primarily responsible for making the resource Walawalkar, Rahul S. Date A point or period of time associated with an event in the lifecycle of the resource 2003 Publisher An entity responsible for making the resource available New York Institute of Technology Subject The topic of the resource Energy conservation -- United States. Technology -- United States. Language A language of the resource English Format The file format, physical medium, or dimensions of the resource PDF Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context <a href="https://repository.nyitlibrary.org/files/original/d0f38ea42222375f8057c73f75c790bb.pdf">https://repository.nyitlibrary.org/files/original/d0f38ea42222375f8057c73f75c790bb.pdf</a> Energy Management Thesis https://repository.nyitlibrary.org/files/original/87fc1d971e7b37c8b006b09cb79cb243.pdf 4f7d6f4a615019fd361c118d4837d512 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource NYITCOM - Faculty Publications Publication Book or Journal Article published by New York Tech Facility. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Inhibition of metastatic brain cancer in Sonic Hedgehog medulloblastoma using caged nitric oxide albumin nanoparticles Identifier An unambiguous reference to the resource within a given context <a href="https://repository.nyitlibrary.org/files/original/87fc1d971e7b37c8b006b09cb79cb243.pdf">https://repository.nyitlibrary.org/files/original/87fc1d971e7b37c8b006b09cb79cb243.pdf</a> <a href="https://doi.org/10.3389/fonc.2023.1129533">https://doi.org/10.3389/fonc.2023.1129533</a> Creator An entity primarily responsible for making the resource Soltys, B. J., Grausam, K. B., Messerli, S. M., Hsia, C. J. C., & Zhao, H. Date A point or period of time associated with an event in the lifecycle of the resource 2023 Publisher An entity responsible for making the resource available Frontiers Media SA Subject The topic of the resource Neoplasms Tumors Oncology Cancer Carcinogens Sonic Hedgehog Hematogenous dissemination Leptomeningeal dissemination Medulloblastoma Metastasis Nitroxide Language A language of the resource English Abstract A summary of the resource. Medulloblastoma is a tumor of the cerebellum that metastasizes to the leptomeninges of the central nervous system (CNS), including to forebrain and to spinal cord. The inhibitory effect of polynitroxylated albumin (PNA), a caged nitroxide nanoparticle, on leptomeningeal dissemination and metastatic tumor growth was studied in a Sonic Hedgehog transgenic mouse model. PNA treated mice showed an increased lifespan with a mean survival of 95 days (n = 6, P<0.05) compared with 71 days in controls. In primary tumors, proliferation was significantly reduced and differentiation was significantly increased (P<0.001) as shown by Ki-67+ and NeuN+ immunohistochemistry, while cells in spinal cord tumors appeared unaffected. Yet, histochemical analysis of metastatic tumor in spinal cord showed that the mean total number of cells in spinal cord was significantly reduced in mice treated with PNA compared to albumin vehicle (P<0.05). Examination of various levels of the spinal cord showed that PNA treated mice had significantly reduced metastatic cell density in the thoracic, lumbar and sacral spinal cord levels (P<0.05), while cell density in the cervical region was not significantly changed. The mechanism by which PNA may exert these effects on CNS tumors is discussed. Source A related resource from which the described resource is derived Frontiers in Oncology, Volume 13, May 2023 Rights Information about rights held in and over the resource Copyright © 2023 Soltys, Grausam, Messerli, Hsia and Zhao. This is an open-access article distributed under the terms of the <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank" rel="noreferrer noopener">Creative Commons Attribution License (CC BY)</a>. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Format The file format, physical medium, or dimensions of the resource PDF Type The nature or genre of the resource Text Bibliographic Citation A bibliographic reference for the resource. Recommended practice is to include sufficient bibliographic detail to identify the resource as unambiguously as possible. Soltys, B. J., Grausam, K. B., Messerli, S. M., Hsia, C. J. C., & Zhao, H. (2023). Inhibition of metastatic brain cancer in Sonic Hedgehog medulloblastoma using caged nitric oxide albumin nanoparticles. In Frontiers in Oncology (Vol. 13). Frontiers Media SA. <a href="https://doi.org/10.3389/fonc.2023.1129533">https://doi.org/10.3389/fonc.2023.1129533</a> https://repository.nyitlibrary.org/files/original/6a7ee466006a0a384e7f03ab96c87839.pdf d712eb308a0c80304315ef862ca86dbc Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource NYITCOM - Faculty Publications Publication Book or Journal Article published by New York Tech Facility. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Injuries in a Mysticete Skeleton from the Miocene of Virginia, With a Discussion of Buoyancy and the Primitive Feeding Mode in the Chaeomysticeti Creator An entity primarily responsible for making the resource Brian L. Beatty & Alton C. Dooley, Jr. Identifier An unambiguous reference to the resource within a given context https://repository.nyitlibrary.org/files/original/6a7ee466006a0a384e7f03ab96c87839.pdf Date A point or period of time associated with an event in the lifecycle of the resource 2009 Publisher An entity responsible for making the resource available Virginia Museum of Natural History Subject The topic of the resource Paleopathology Bone fracture Cetacea Mysticeti Miocene Calvert Formation Osteosclerosis Language A language of the resource English Format The file format, physical medium, or dimensions of the resource PDF Abstract A summary of the resource. A mostly complete skeleton of a mysticete from the Carmel Church Quarry displays some injuries, including a fractured and partially-healed left mandible, previously not reported in any fossil mysticete. The mostly healed nature of this non-union impaction fracture indicates that the animal died a significant amount of time after the injury. Additional injuries of the postglenoid process and left premaxilla, as well as the nature of the impaction fracture in the mandible suggest that the cause of this was some impact from the left anterior aspect. Possible scenarios for how this injury could have happened include intraspecific aggression and, more likely, impact with the seafloor during benthic feeding. The ribs of this individual are heavily osteosclerotic from dorsal to ventral ends, which would suggest that this taxon was a benthic feeder. In comparison with a sample of ribs from fossil mysticetes, it appears that Diorocetus may have been one of the last mysticetes with rib osteosclerosis, a feature possibly primitive to Mysticeti. Although this remains speculative, the presence of osteosclerotic ribs in primitive mysticetes suggests that the feeding mode employed by the earliest Chaeomysticeti was one of benthic feeding. Source A related resource from which the described resource is derived Jeffersoniana Number 20, August 2009 Rights Information about rights held in and over the resource <a title="The Virginia Freedom of Information Act (FOIA), § 2.2-3700 et seq. of the Code of Virginia" href="https://law.lis.virginia.gov/vacode/title2.2/chapter37/section2.2-3704.1/">The Virginia Freedom of Information Act (FOIA), § 2.2-3700 et seq. of the Code of Virginia</a>, guarantees citizens of the Commonwealth and representatives of the media access to public records held by public bodies, public officials, and public employees. Type The nature or genre of the resource Text Bibliographic Citation A bibliographic reference for the resource. Recommended practice is to include sufficient bibliographic detail to identify the resource as unambiguously as possible. Beatty, B.L. & Dooley, A.C. (2009). Injuries in a Mysticete Skeleton from the Miocene of Virginia , With a Discussion of Buoyancy and the Primitive Feeding Mode in the Chaeomysticeti. bone fracture Calvert Formation Cetacea Miocene Mysticeti osteosclerosis paleopathology https://repository.nyitlibrary.org/files/original/1c52382896ad52c9a2edb9a86c867f6d.pdf 3e3565ad883dd42552de8c8414174bb5 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Training & Learning Technology - Dissertations & Theses Thesis A long essay or dissertation involving personal research, written by a candidate for a college degree. School School of Media and Arts Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Inland Waters Night Lighting Configurations : A Navigation Rules Course for Coast Guard Auxiliarists Creator An entity primarily responsible for making the resource Griffiths, Gregory Peter Date A point or period of time associated with an event in the lifecycle of the resource [1990] Publisher An entity responsible for making the resource available New York Institute of Technology Subject The topic of the resource Navigation--Safety measures--Study and teaching Ships--Lighting--Study and teaching Language A language of the resource English Format The file format, physical medium, or dimensions of the resource PDF Type The nature or genre of the resource Thesis (M.S.)--New York Institute of Technology Identifier An unambiguous reference to the resource within a given context <a href="https://repository.nyitlibrary.org/files/original/1c52382896ad52c9a2edb9a86c867f6d.pdf">https://repository.nyitlibrary.org/files/original/1c52382896ad52c9a2edb9a86c867f6d.pdf</a> Thesis Training https://repository.nyitlibrary.org/files/original/69b133aadc070e47a5da0ca9412414a8.pdf 95a87d743cb48158b793a012a9302361 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Architecture & Design - Dissertations & Theses Thesis A long essay or dissertation involving personal research, written by a candidate for a college degree. School School of Architecture & Design Department Department of Architecture Degree Bachelor of Architecture B.Arch. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Innovation and Building Materials Creator An entity primarily responsible for making the resource Vishesh Patel Date A point or period of time associated with an event in the lifecycle of the resource 2023 Identifier An unambiguous reference to the resource within a given context https://repository.nyitlibrary.org/files/original/69b133aadc070e47a5da0ca9412414a8.pdf Subject The topic of the resource Architecture and technology. Architecture--Technological innovations. Building materials industry--Appropriate technology. Source A related resource from which the described resource is derived New York Institute of Technology, 2023 Publisher An entity responsible for making the resource available Old Westbury, N.Y. : New York Institute of Technology, 2023. Language A language of the resource English Format The file format, physical medium, or dimensions of the resource PDF Type The nature or genre of the resource Thesis (Master of Architecture)--New York Institute of Technology, 2023 ISBN: 9798211216266 https://repository.nyitlibrary.org/files/original/957a50a92f87e90af6f9a5afd1bb180c.pdf ef5605fb013375df98be702fda9adaba Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Business Administration - Dissertations & Theses Thesis A long essay or dissertation involving personal research, written by a candidate for a college degree. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Innovation in financing : foreign firms' financing of research and development through American tax shelters. Creator An entity primarily responsible for making the resource Peretz, Samuel. Date A point or period of time associated with an event in the lifecycle of the resource 1982 Publisher An entity responsible for making the resource available New York Institute of Technology Subject The topic of the resource Research and development tax credit. Language A language of the resource English Format The file format, physical medium, or dimensions of the resource PDF Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context https://repository.nyitlibrary.org/files/original/957a50a92f87e90af6f9a5afd1bb180c.pdf https://repository.nyitlibrary.org/files/original/85585287e233067bde70aeadc4181cb4.pdf 44b7621d6329bce83ce6278b95bbab77 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Environmental Technology & Sustainability - Dissertations & Theses Thesis A long essay or dissertation involving personal research, written by a candidate for a college degree. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Inside Air Quality : A Problem for the Millen[n]ium Creator An entity primarily responsible for making the resource Gaglio, John T. Date A point or period of time associated with an event in the lifecycle of the resource 1999 Publisher An entity responsible for making the resource available New York Institute of Technology. Subject The topic of the resource Air quality management--Standards--United States. Indoor air pollution--Standards--United States. Language A language of the resource English. Format The file format, physical medium, or dimensions of the resource PDF. Type The nature or genre of the resource Thesis (M.S.)--New York Institute of Technology. Identifier An unambiguous reference to the resource within a given context <a href="https://repository.nyitlibrary.org/files/original/85585287e233067bde70aeadc4181cb4.pdf">https://repository.nyitlibrary.org/files/original/85585287e233067bde70aeadc4181cb4.pdf</a> Environment Thesis https://repository.nyitlibrary.org/files/original/22778967a88e42463b4269f7ff388f00.pdf 9446c328ed7496056e1ae43c701fc7f4 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource School of Engineering & Computing Sciences Thesis A long essay or dissertation involving personal research, written by a candidate for a college degree. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Installing a Solar Pathway in the East Village : Feasibility of Solar Street Lamps Creator An entity primarily responsible for making the resource Griffin, Mary C. Date A point or period of time associated with an event in the lifecycle of the resource 2011 Publisher An entity responsible for making the resource available New York Institute of Technology Subject The topic of the resource Street lighting--East Village (New York, N.Y.) Solar cells. Photovoltaic power generation. Language A language of the resource English Format The file format, physical medium, or dimensions of the resource PDF Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context <a href="https://repository.nyitlibrary.org/files/original/22778967a88e42463b4269f7ff388f00.pdf">https://repository.nyitlibrary.org/files/original/22778967a88e42463b4269f7ff388f00.pdf</a> computer science Energy Thesis https://repository.nyitlibrary.org/files/original/d8dda55614ad54f6f8b5f1a9ed936167.pdf 6a8c13bcc79a30272c32d7601a9759fc Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Training & Learning Technology - Dissertations & Theses Thesis A long essay or dissertation involving personal research, written by a candidate for a college degree. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Instructing Students in Writing the Composition Section of the Regents Competency Test Creator An entity primarily responsible for making the resource Behrens, Doris Date A point or period of time associated with an event in the lifecycle of the resource 1990 Publisher An entity responsible for making the resource available New York Institute of Technology Subject The topic of the resource Composition (Language arts)--Study and teaching (Secondary) Language A language of the resource English Format The file format, physical medium, or dimensions of the resource PDF Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context <a href="https://repository.nyitlibrary.org/files/original/d8dda55614ad54f6f8b5f1a9ed936167.pdf">https://repository.nyitlibrary.org/files/original/d8dda55614ad54f6f8b5f1a9ed936167.pdf</a> https://repository.nyitlibrary.org/files/original/8d704024e5374be33c27b56f6d1fab45.pdf b35381d287d9fefe1e03b7d3c0629a05 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Training & Learning Technology - Dissertations & Theses Thesis A long essay or dissertation involving personal research, written by a candidate for a college degree. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Instructional Program for Developing Novice Proofreading Skills in the Computerized Typography Industry Publisher An entity responsible for making the resource available New York Institute of Technology Language A language of the resource English Format The file format, physical medium, or dimensions of the resource PDF Type The nature or genre of the resource Text Creator An entity primarily responsible for making the resource Kelleher, Daniel J. Date A point or period of time associated with an event in the lifecycle of the resource 1988 Subject The topic of the resource Employees--Training of. Proofreading. Identifier An unambiguous reference to the resource within a given context <a href="https://repository.nyitlibrary.org/files/original/8d704024e5374be33c27b56f6d1fab45.pdf">https://repository.nyitlibrary.org/files/original/8d704024e5374be33c27b56f6d1fab45.pdf</a> Thesis Training https://repository.nyitlibrary.org/files/original/c06c760899d29021dba643f5f575106f.pdf a90bb65b74f423074b144a9c7ca8dc86 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource NYITCOM - Faculty Publications Publication Book or Journal Article published by New York Tech Facility. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Insulin and Igf-1 Elicit Robust Transcriptional Regulation to Modulate Autophagy in Astrocytes Identifier An unambiguous reference to the resource within a given context <a href="https://repository.nyitlibrary.org/files/original/c06c760899d29021dba643f5f575106f.pdf">https://repository.nyitlibrary.org/files/original/c06c760899d29021dba643f5f575106f.pdf</a> <a href="https://doi.org/10.1016/j.molmet.2022.101647">https://doi.org/10.1016/j.molmet.2022.101647</a> Creator An entity primarily responsible for making the resource Geffken, S. J., Moon, S., Smith, C. O., Tang, S., Lee, H. H., Lewis, K., Wong, C. W., Huang, Y., Huang, Q., Zhao, Y.-T., & Cai, W. Date A point or period of time associated with an event in the lifecycle of the resource 2022 Publisher An entity responsible for making the resource available Elsevier BV Subject The topic of the resource Insuling IGF-1 Astrocytes Transcription Autophagy Proteostasis Language A language of the resource English Abstract A summary of the resource. <h4>Objective</h4> Insulin is a principal metabolic hormone. It regulates a plethora of metabolic pathways in peripheral tissues. The highly homologous insulin-like growth factor 1 (IGF-1), on the other hand, is important for development and growth. Recent studies have shown that insulin and IGF-1 signaling plays fundamental roles in the brain. Loss of insulin or IGF-1 receptors in astrocytes leads to altered glucose handling, mitochondrial metabolism, neurovascular coupling, and behavioral abnormalities in mice. Here, we aim to investigate molecular mechanisms by which insulin and IGF-1 signaling regulates astrocyte functions. <h4>Methods</h4> IR-flox and IRKO primary astrocytes were treated with 100 nM insulin or IGF-1 for 6 h, and their transcriptomes were analyzed. Astrocytes with either IR deletion, IGF1R deletion or both were used to examine receptor-dependent transcriptional regulations using qPCR. Additional immunoblotting and confocal imaging studies were performed to functionally validate pathways involved in protein homeostasis. <h4>Results</h4> Using next-generation RNA sequencing, we show that insulin significantly regulates the expression of over 1,200 genes involved in multiple functional processes in primary astrocytes. Insulin-like growth factor 1 (IGF-1) triggers a similar robust transcriptional regulation in astrocytes. Thus, over 50% of the differentially expressed genes are regulated by both ligands. As expected, these commonly regulated genes are highly enriched in pathways involved in lipid and cholesterol biosynthesis. Additionally, insulin and IGF-1 induce the expression of genes involved in ribosomal biogenesis, while suppressing the expression of genes involved in autophagy, indicating a common role of insulin and IGF-1 on protein homeostasis in astrocytes. Insulin-dependent suppression of autophagy genes, including p62 , Ulk1/2 , and several Atg genes, is blunted only when both IR and IGF1R are deleted. <h4>Conclusions</h4> In summary, insulin and IGF-1 potently suppress autophagy in astrocytes through transcriptional regulation. Both IR and IGF1R can elicit ligand-dependent transcriptional suppression of autophagy. These results demonstrate an important role of astrocytic insulin/IGF-1 signaling on proteostasis. Impairment of this regulation in insulin resistance and diabetes may contribute to neurological complications related to diabetes. Source A related resource from which the described resource is derived Molecular Metabolism Volume 66, December 2022, page 101647 Rights Information about rights held in and over the resource Copyright © 2022 The Authors Format The file format, physical medium, or dimensions of the resource PDF Type The nature or genre of the resource Text Bibliographic Citation A bibliographic reference for the resource. Recommended practice is to include sufficient bibliographic detail to identify the resource as unambiguously as possible. Geffken, S. J., Moon, S., Smith, C. O., Tang, S., Lee, H. H., Lewis, K., Wong, C. W., Huang, Y., Huang, Q., Zhao, Y.-T., & Cai, W. (2022). Insulin and IGF-1 elicit robust transcriptional regulation to modulate autophagy in astrocytes. In Molecular Metabolism (Vol. 66, p. 101647). Elsevier BV. <a href="https://doi.org/10.1016/j.molmet.2022.101647">https://doi.org/10.1016/j.molmet.2022.101647</a> astrocytes autophagy igf-1 insulin proteostasis transcription https://repository.nyitlibrary.org/files/original/f75c36cbee64286a7ac9d628c5b3ce37.pdf 8f7cb56b711c4219529606d12db88024 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Energy Management - Dissertations & Theses Thesis A long essay or dissertation involving personal research, written by a candidate for a college degree. School School of Management Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Integrated Coal Gasification Combined Cycle Creator An entity primarily responsible for making the resource Yuktasevi, Siriwong Date A point or period of time associated with an event in the lifecycle of the resource 1990 Publisher An entity responsible for making the resource available New York Institute of Technology Subject The topic of the resource Coal gasification plants. Coal gasification. Language A language of the resource English Format The file format, physical medium, or dimensions of the resource PDF Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context <a href="https://repository.nyitlibrary.org/files/original/f75c36cbee64286a7ac9d628c5b3ce37.pdf">https://repository.nyitlibrary.org/files/original/f75c36cbee64286a7ac9d628c5b3ce37.pdf</a> Energy Management Thesis https://repository.nyitlibrary.org/files/original/a1832883059cc0123cad097003bd9943.pdf a46a583cf7b660097366ec7809b039b9 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource School of Engineering & Computing Sciences Thesis A long essay or dissertation involving personal research, written by a candidate for a college degree. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Integrated Waste Management for New York City Creator An entity primarily responsible for making the resource Coleman, Joseph Date A point or period of time associated with an event in the lifecycle of the resource 1996 Publisher An entity responsible for making the resource available New York Institute of Technology Subject The topic of the resource Infectious wastes--New York (State)--New York Integrated solid waste management--New York (State)--New York Language A language of the resource English Format The file format, physical medium, or dimensions of the resource PDF Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context <a href="https://repository.nyitlibrary.org/files/original/a1832883059cc0123cad097003bd9943.pdf">https://repository.nyitlibrary.org/files/original/a1832883059cc0123cad097003bd9943.pdf</a> computer science Energy Thesis https://repository.nyitlibrary.org/files/original/d50423bee2f911f8f708351c3b2cf2ee.pdf 44b5e6aa2b06ccf1c6167b6af006778c Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Energy Management - Dissertations & Theses Thesis A long essay or dissertation involving personal research, written by a candidate for a college degree. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Integrating power transmission providers into the transparent competitive market. Creator An entity primarily responsible for making the resource McLean, Dewey Q. Date A point or period of time associated with an event in the lifecycle of the resource 2003 Publisher An entity responsible for making the resource available New York Institute of Technology Subject The topic of the resource Electric power distribution--United States. Electric power production--United States. Electric utilities--Deregulation--United States. Language A language of the resource English Format The file format, physical medium, or dimensions of the resource PDF Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context https://repository.nyitlibrary.org/files/original/d50423bee2f911f8f708351c3b2cf2ee.pdf Energy Management Thesis