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                <text>Novel beta-blocker pretreatment prevents alcohol-induced atrial fibrillation in a rat model</text>
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                <text>Alcohol&#13;
Atrial fibrillation&#13;
Atrial fibrillation inducibility&#13;
Beta-blocker&#13;
Effective refractory period</text>
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                <text>&lt;div class="sec sec-first"&gt;
&lt;h3&gt;Background&lt;/h3&gt;
&lt;p class="p p-first-last"&gt;A case report published in 2019 described a patient who presented with difficult-to-manage atrial fibrillation (AF) that consistently was associated with alcohol consumption. After the patient did not respond to drug therapy, a novel beta-blocker (BB) pretreatment regimen initiated immediately before alcohol consumption successfully prevented AF occurrence.&lt;/p&gt;
&lt;/div&gt;
&lt;div class="sec"&gt;
&lt;h3&gt;Objective&lt;/h3&gt;
&lt;p class="p p-first-last"&gt;The purpose of this study was to test the hypothesis that a novel prophylactic BB therapy given before alcohol consumption could prevent AF in a rat model.&lt;/p&gt;
&lt;/div&gt;
&lt;div class="sec"&gt;
&lt;h3&gt;Methods&lt;/h3&gt;
&lt;p class="p p-first-last"&gt;An alcohol-induced AF model was developed in adult Sprague-Dawley rats of both sexes by administering alcohol (2 g/kg intraperitoneal [IP]) once every other day for a total of 4 times. Three groups were enrolled: alcohol (EtOH; n = 10); alcohol plus BB (metoprolol 50 mg/kg IP) pretreatment (EtOH+BB; n = 10); and control (n = 9). Cardiac function (assessed by echocardiography and left ventricular hemodynamics) and&lt;span&gt; &lt;/span&gt;&lt;em&gt;in vivo&lt;/em&gt;&lt;span&gt; &lt;/span&gt;atrial electrophysiology and AF inducibility tests were performed 24 hours after the last injection.&lt;/p&gt;
&lt;/div&gt;
&lt;div class="sec"&gt;
&lt;h3&gt;Results&lt;/h3&gt;
&lt;p class="p p-first-last"&gt;All but 1 rat completed the study. Alcohol exposure did not significantly impact cardiac function and the atrial effective refractory period. However, alcohol exposure significantly increased AF inducibility [median (first and third quartile [Q1–Q3]) 0% (0%–0%) in control vs 60% (25%–100%) in the EtOH group;&lt;span&gt; &lt;/span&gt;&lt;em&gt;P&lt;/em&gt; &amp;lt;.05] and AF duration [0 second (0–0 second) in control vs 0.81 second (0.24–3.67 seconds) in the EtOH group;&lt;span&gt; &lt;/span&gt;&lt;em&gt;P&lt;/em&gt;&lt;span&gt; &lt;/span&gt;&amp;lt;.05]. Compared to the EtOH group, the EtOH+BB group had significantly reduced AF inducibility [0% (0%–22.5%);&lt;span&gt; &lt;/span&gt;&lt;em&gt;P&lt;/em&gt;&lt;span&gt; &lt;/span&gt;&amp;lt;.05] and duration [0 second (0–0.2 second);&lt;span&gt; &lt;/span&gt;&lt;em&gt;P&lt;/em&gt;&lt;span&gt; &lt;/span&gt;&amp;lt;.05].&lt;/p&gt;
&lt;/div&gt;
&lt;div class="sec sec-last"&gt;
&lt;h3&gt;Conclusion&lt;/h3&gt;
&lt;p class="p p-first-last"&gt;Metoprolol pretreatment before alcohol administration significantly decreased AF induction in rats. These findings suggest that BB pretreatment is a promising prophylaxis regimen for alcohol-induced AF.&lt;/p&gt;
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                <text>Hassan, H., Greco, L. V., Meshoyrer, D. I., Li, Y., Zhang, Y., &amp;amp; Cohen, T. J. (2020). Novel beta-blocker pretreatment prevents alcohol-induced atrial fibrillation in a rat model. In Heart Rhythm O2 (Vol. 1, Issue 2, pp. 120–125). Elsevier BV. &lt;a href="https://doi.org/10.1016/j.hroo.2020.02.006"&gt;https://doi.org/10.1016/j.hroo.2020.02.006&lt;/a&gt;</text>
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                <text>Alligators and Crocodiles anatomy &amp; histology growth &amp; development&#13;
Animals&#13;
Biological Evolution&#13;
Brain anatomy &amp; histology growth &amp; development&#13;
Chickens anatomy &amp; histology growth &amp; development&#13;
Dryad 10.5061/dryad.qv9s4mwdk&#13;
Index Medicus&#13;
Male&#13;
Alligator&#13;
Aves&#13;
Brain evolution&#13;
Chicken&#13;
Dinosauria&#13;
Evolutionary biology&#13;
Geometric morphometrics&#13;
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                <text>How do large and unique brains evolve? Historically, comparative neuroanatomical studies have attributed the evolutionary genesis of highly encephalized brains to deviations along, as well as from, conserved scaling relationships among brain regions. However, the relative contributions of these concerted (integrated) and mosaic (modular) processes as drivers of brain evolution remain unclear, especially in non-mammalian groups. While proportional brain sizes have been the predominant metric used to characterize brain morphology to date, we perform a high-density geometric morphometric analysis on the encephalized brains of crown birds (Neornithes or Aves) compared to their stem taxa—the non-avialan coelurosaurian dinosaurs and Archaeopteryx. When analyzed together with developmental neuroanatomical data of model archosaurs (Gallus, Alligator), crown birds exhibit a distinct allometric relationship that dictates their brain evolution and development. Furthermore, analyses by neuroanatomical regions reveal that the acquisition of this derived shape-to-size scaling relationship occurred in a mosaic pattern, where the avian-grade optic lobe and cerebellum evolved first among non-avialan dinosaurs, followed by major changes to the evolutionary and developmental dynamics of cerebrum shape after the origin of Avialae. Notably, the brain of crown birds is a more integrated structure than non-avialan archosaurs, implying that diversification of brain morphologies within Neornithes proceeded in a more coordinated manner, perhaps due to spatial constraints and abbreviated growth period. Collectively, these patterns demonstrate a plurality in evolutionary processes that generate encephalized brains in archosaurs and across vertebrates.</text>
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                <text>&lt;em&gt;eLife&lt;/em&gt;, Volume 10, July 2021</text>
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                <text>&lt;span&gt;Watanabe, A., Balanoff, A. M., Gignac, P. M., Gold, M. E. L., &amp;amp; Norell, M. A. (2021). Novel neuroanatomical integration and scaling define avian brain shape evolution and development. In eLife (Vol. 10). eLife Sciences Publications, Ltd. &lt;a href="https://doi.org/10.7554/elife.68809"&gt;https://doi.org/10.7554/elife.68809&lt;/a&gt;&lt;/span&gt;</text>
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                <text>Rajagopalan, V., Chakraborty, S., &amp; Lin, R.</text>
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                <text>Cancer&#13;
Heart&#13;
Interactome&#13;
Noncoding RNAs&#13;
Thyroid hormones&#13;
Transcriptome</text>
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                <text>Noncoding RNAs are emerging as vital players in cardiovascular diseases. Thyroid hormones (THs) are crucial for cardiovascular survival; however, correction of systemic hypothyroidism (low serum THs) may not improve cardiac tissue-level hypothyroidism or cardiac function. Mechanistically, the understanding of noncoding transcriptomic interactions influencing TH-mediated cardiac effects is unclear. Adult C57BL/6J mixed-sex mice were randomized into Control, Hypothyroid (HypoTH), Hyperthyroid (HyperTH), and HypoTH-Triiodothyronine restoration groups. Physiological, morphological, biochemical, molecular, and whole transcriptomic studies and appropriate statistical analyses were performed. HypoTH showed significant atrophy, depressed cardiac function, and decreased serum THs versus controls, and Triiodothyronine supplementation restored them. HyperTH significantly increased serum THs with hypertrophy. Real-time PCR showed significantly altered inflammatory and immune lncRNAs. The transcriptomic sequencing revealed significant differential expressions of lncRNAs, miRNAs, and mRNAs. Eleven novel circRNAs significantly decreased with increased THs. Multiple pathways were GO-/KEGG-enriched, including cardiac, thyroid, cancer, mitochondrial, inflammatory, adrenergic, metabolic, immune-mediated, vesicular, etc. We also uncovered significant novel co-expression and interactions of lncRNA-miRNA, lncRNA-miRNA-mRNA, lncRNA-mRNA, circRNA-miRNA, and miRNA-mRNA, and splicing events. This includes a novel pathway by which the predominant cardiac TH receptor alpha may interact with specific lncRNAs and miRNAs. This is the first study reporting a comprehensive transcriptome-wide interactome in the cardiac-thyroid axis.</text>
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                <text>&lt;em&gt;International Journal of Molecular Sciences&lt;/em&gt;, Volume 24, Issue 7, March 2023, page 6560</text>
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                <text>&lt;span&gt;© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (&lt;/span&gt;&lt;a href="https://creativecommons.org/licenses/by/4.0/" target="_blank" rel="noreferrer noopener"&gt;https://creativecommons.org/licenses/by/4.0/&lt;/a&gt;&lt;span&gt;).&lt;/span&gt;</text>
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