2
20
2876
-
https://repository.nyitlibrary.org/files/original/45fb0fa9261ac518b5a1a88b1977f092.pdf
43a0a1995cc615110f9b928e21f7ba63
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Title
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NYITCOM - Faculty Publications
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Book or Journal Article published by New York Tech Facility.
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ALT Positivity in Human Cancers: Prevalence and Clinical Insights
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<a href="https://repository.nyitlibrary.org/files/original/45fb0fa9261ac518b5a1a88b1977f092.pdf">https://repository.nyitlibrary.org/files/original/45fb0fa9261ac518b5a1a88b1977f092.pdf</a>
<a href="https://doi.org/10.3390/cancers13102384">https://doi.org/10.3390/cancers13102384</a>
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MacKenzie, D., Jr., Watters, A. K., To, J. T., Young, M. W., Muratori, J., Wilkoff, M. H., Abraham, R. G., Plummer, M. M., & Zhang, D.
Date
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2021
Publisher
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MDPI AG
Subject
The topic of the resource
Alternative lengthening of telomeres
Cancers
ALT biomarkers
ATRX
DAXX
Language
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English
Abstract
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<span>Many exciting advances in cancer-related telomere biology have been made in the past decade. Of these recent advances, great progress has also been made with respect to the Alternative Lengthening of Telomeres (ALT) pathway. Along with a better understanding of the molecular mechanism of this unique telomere maintenance pathway, many studies have also evaluated ALT activity in various cancer subtypes. We first briefly review and assess a variety of commonly used ALT biomarkers. Then, we provide both an update on ALT-positive (ALT+) tumor prevalence as well as a systematic clinical assessment of the presently studied ALT+ malignancies. Additionally, we discuss the pathogenetic alterations in ALT+ cancers, for example, the mutation status of </span><span class="html-italic">ATRX</span><span> and </span><span class="html-italic">DAXX</span><span>, and their correlations with the activation of the ALT pathway. Finally, we highlight important ALT+ clinical associations within each cancer subtype and subdivisions within, as well as their prognoses. We hope this alternative perspective will allow scientists, clinicians, and drug developers to have greater insight into the ALT cancers so that together, we may develop more efficacious treatments and improved management strategies to meet the urgent needs of cancer patients.</span>
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<em>Cancers</em>, Volume 13, Issue 10, May 2021, Page 2384
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<span>All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited.</span>
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Text
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<span>MacKenzie, D., Jr., Watters, A. K., To, J. T., Young, M. W., Muratori, J., Wilkoff, M. H., Abraham, R. G., Plummer, M. M., & Zhang, D. (2021). ALT Positivity in Human Cancers: Prevalence and Clinical Insights. In Cancers (Vol. 13, Issue 10, p. 2384). MDPI AG. <a href="https://doi.org/10.3390/cancers13102384">https://doi.org/10.3390/cancers13102384</a></span>
ALT biomarkers
alternative lengthening of telomeres
ATRX
cancer
DAXX
-
https://repository.nyitlibrary.org/files/original/14d9cdb896c7e10dfb1a7589eae93b7e.pdf
648a34a3fd5f8d4ba5800b55a72f5ab5
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Title
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NYITCOM - Faculty Publications
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Book or Journal Article published by New York Tech Facility.
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Computational Biology: A New Frontier in Applied Biology
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<a href="https://repository.nyitlibrary.org/files/original/45fb0fa9261ac518b5a1a88b1977f092.pdf">https://repository.nyitlibrary.org/files/original/45fb0fa9261ac518b5a1a88b1977f092.pdf</a>
<a href="https://doi.org/10.3390/biology10050374">https://doi.org/10.3390/biology10050374</a>
<a href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</a>
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<em>Biology </em>Volume 10, Issue 5, April 2021, page 374
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<div class="fm-copyright half_rhythm">
<div class="fm-copyright half_rhythm"><a href="https://www.ncbi.nlm.nih.gov/pmc/about/copyright/">Copyright</a><span> </span>© 2021 by the authors.</div>
<div class="license half_rhythm">Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (<a href="https://creativecommons.org/licenses/by/4.0/" target="_blank" rel="noreferrer noopener">https://creativecommons.org/licenses/by/4.0/</a>).</div>
</div>
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PDF
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Text
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<span>MacKenzie, D., Jr., Watters, A. K., To, J. T., Young, M. W., Muratori, J., Wilkoff, M. H., Abraham, R. G., Plummer, M. M., & Zhang, D. (2021). ALT Positivity in Human Cancers: Prevalence and Clinical Insights. In Cancers (Vol. 13, Issue 10, p. 2384). MDPI AG. <a href="https://doi.org/10.3390/cancers13102384">https://doi.org/10.3390/cancers13102384</a></span>
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Toma, M., & Concu, R.
Date
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2021
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MDPI AG
Language
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English
Subject
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Computational Biology
Computational techniques
-
https://repository.nyitlibrary.org/files/original/c06c760899d29021dba643f5f575106f.pdf
a90bb65b74f423074b144a9c7ca8dc86
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Title
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NYITCOM - Faculty Publications
Publication
Book or Journal Article published by New York Tech Facility.
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Title
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Insulin and Igf-1 Elicit Robust Transcriptional Regulation to Modulate Autophagy in Astrocytes
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<a href="https://repository.nyitlibrary.org/files/original/c06c760899d29021dba643f5f575106f.pdf">https://repository.nyitlibrary.org/files/original/c06c760899d29021dba643f5f575106f.pdf</a>
<a href="https://doi.org/10.1016/j.molmet.2022.101647">https://doi.org/10.1016/j.molmet.2022.101647</a>
Creator
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Geffken, S. J., Moon, S., Smith, C. O., Tang, S., Lee, H. H., Lewis, K., Wong, C. W., Huang, Y., Huang, Q., Zhao, Y.-T., & Cai, W.
Date
A point or period of time associated with an event in the lifecycle of the resource
2022
Publisher
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Elsevier BV
Subject
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Insuling
IGF-1
Astrocytes
Transcription
Autophagy
Proteostasis
Language
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English
Abstract
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<h4>Objective</h4>
<p>Insulin is a principal metabolic hormone. It regulates a plethora of metabolic pathways in peripheral tissues. The highly homologous insulin-like growth factor 1 (IGF-1), on the other hand, is important for development and growth. Recent studies have shown that insulin and IGF-1 signaling plays fundamental roles in the brain. Loss of insulin or IGF-1 receptors in astrocytes leads to altered glucose handling, mitochondrial metabolism, neurovascular coupling, and behavioral abnormalities in mice. Here, we aim to investigate molecular mechanisms by which insulin and IGF-1 signaling regulates astrocyte functions.</p>
<h4>Methods</h4>
<p>IR-flox and IRKO primary astrocytes were treated with 100 nM insulin or IGF-1 for 6 h, and their transcriptomes were analyzed. Astrocytes with either IR deletion, IGF1R deletion or both were used to examine receptor-dependent transcriptional regulations using qPCR. Additional immunoblotting and confocal imaging studies were performed to functionally validate pathways involved in protein homeostasis.</p>
<h4>Results</h4>
<p>Using next-generation RNA sequencing, we show that insulin significantly regulates the expression of over 1,200 genes involved in multiple functional processes in primary astrocytes. Insulin-like growth factor 1 (IGF-1) triggers a similar robust transcriptional regulation in astrocytes. Thus, over 50% of the differentially expressed genes are regulated by both ligands. As expected, these commonly regulated genes are highly enriched in pathways involved in lipid and cholesterol biosynthesis. Additionally, insulin and IGF-1 induce the expression of genes involved in ribosomal biogenesis, while suppressing the expression of genes involved in autophagy, indicating a common role of insulin and IGF-1 on protein homeostasis in astrocytes. Insulin-dependent suppression of autophagy genes, including<span> </span><i>p62</i><span> </span>,<span> </span><i>Ulk1/2</i><span> </span>, and several<span> </span><i>Atg</i><span> </span>genes, is blunted only when both IR and IGF1R are deleted.</p>
<h4>Conclusions</h4>
<p>In summary, insulin and IGF-1 potently suppress autophagy in astrocytes through transcriptional regulation. Both IR and IGF1R can elicit ligand-dependent transcriptional suppression of autophagy. These results demonstrate an important role of astrocytic insulin/IGF-1 signaling on proteostasis. Impairment of this regulation in insulin resistance and diabetes may contribute to neurological complications related to diabetes.</p>
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<em>Molecular Metabolism</em> Volume 66, December 2022, page 101647
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Copyright © 2022 The Authors
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PDF
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Text
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<span>Geffken, S. J., Moon, S., Smith, C. O., Tang, S., Lee, H. H., Lewis, K., Wong, C. W., Huang, Y., Huang, Q., Zhao, Y.-T., & Cai, W. (2022). Insulin and IGF-1 elicit robust transcriptional regulation to modulate autophagy in astrocytes. In Molecular Metabolism (Vol. 66, p. 101647). Elsevier BV. <a href="https://doi.org/10.1016/j.molmet.2022.101647">https://doi.org/10.1016/j.molmet.2022.101647</a></span>
astrocytes
autophagy
igf-1
insulin
proteostasis
transcription
-
https://repository.nyitlibrary.org/files/original/d6435b99ba57cdb5c696e6393100c27d.pdf
df74526723094e68f12d8ff5caaa913a
Dublin Core
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Title
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NYITCOM - Faculty Publications
Publication
Book or Journal Article published by New York Tech Facility.
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Title
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Utilizing Wearable Technology to Increase Physical Activity in Future Physicians: A Randomized Trial
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<a href="https://repository.nyitlibrary.org/files/original/d6435b99ba57cdb5c696e6393100c27d.pdf">https://repository.nyitlibrary.org/files/original/d6435b99ba57cdb5c696e6393100c27d.pdf</a>
<a href="https://doi.org/10.1016/j.pmedr.2018.09.004"><span>https://doi.org/10.1016/j.pmedr.2018.09.004</span></a>
<a href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</a>
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DiFrancisco-Donoghue, J., Jung, M.-K., Stangle, A., Werner, W. G., Zwibel, H., Happel, P., & Balentine, J.
Date
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2018
Publisher
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Elsevier BV
Subject
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Fitbit
Exercise
Medicine
Obesity
Body composition
Language
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English
Abstract
A summary of the resource.
<span>This study examined the use of activity trackers alone or combined with weekly communication through email to improve activity and body composition over one academic year in <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/medical-student" title="Learn more about medical students from ScienceDirect's AI-generated Topic Pages" class="topic-link">medical students</a>. This </span><a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/randomized-clinical-trial" title="Learn more about randomized clinical trial from ScienceDirect's AI-generated Topic Pages" class="topic-link">randomized clinical trial</a><span> conducted at the New York Institute of Technology from July 7, 2016 through June 4, 2017 enrolled 120 medical students. The first group (Fitbit-Plus) wore activity trackers and received weekly emails offering fitness challenges and lifestyle modification challenges. The second group (Fitbit-Only) received only activity trackers and did not receive weekly emails. The third group (Control) was asked not to purchase an activity tracker of any kind throughout the study. All groups had a body composition analysis prior to the start of the academic year and at the end of the first academic year. Outcome measures included step count and body composition (body fat percentage and lean body mass). The results showed the overall mean daily steps were greater in the Fitbit-Plus group than the Fitbit-Only group for the academic year (7429 ± 2833 vs. 6483 ± 2359) with only months April and May showing a significant difference between the groups (p = 0.011; p = 0.044). Body fat percentage decreased in the Fitbit-Plus overweight women (2.1 ± 1.6%) <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/lean-body-weight" title="Learn more about lean body mass from ScienceDirect's AI-generated Topic Pages" class="topic-link">lean body mass</a> increased in the Fitbit-Plus group in overweight men (2.4 ± 4.6 lbs.). A subsequent finding of this study showed improved body composition in a small sub-group of over-weight students. Weekly behavioral challenges combined with an activity tracker increased step count in medical students compared to an activity tracker alone.</span>
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<em>Preventive Medicine Reports </em>Volume 12, December 2018, pages 122-127
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<span>This is an open access article distributed under the terms of the </span><a href="http://creativecommons.org/licenses/by/4.0/" target="_blank" rel="noreferrer noopener">Creative Commons CC-BY</a><span> license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</span>
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PDF
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Text
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<span>DiFrancisco-Donoghue, J., Jung, M.-K., Stangle, A., Werner, W. G., Zwibel, H., Happel, P., & Balentine, J. (2018). Utilizing wearable technology to increase physical activity in future physicians: A randomized trial. In Preventive Medicine Reports (Vol. 12, pp. 122–127). Elsevier BV. <a href="https://doi.org/10.1016/j.pmedr.2018.09.004">https://doi.org/10.1016/j.pmedr.2018.09.004</a></span>
body composition
exercise
fitbit
medicine
obesity
-
https://repository.nyitlibrary.org/files/original/662bc0d533a7148864cc8eaaea6ed2d1.pdf
2cf8db665ba1aee6052af8ff0b9d365e
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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NYITCOM - Faculty Publications
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Book or Journal Article published by New York Tech Facility.
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Title
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Esports Players, Got Muscle? Competitive Video Game Players’ Physical Activity, Body Fat, Bone Mineral Content, and Muscle Mass in Comparison to Matched Controls
Identifier
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<a href="https://repository.nyitlibrary.org/files/original/c06c760899d29021dba643f5f575106f.pdf">https://repository.nyitlibrary.org/files/original/c06c760899d29021dba643f5f575106f.pdf</a>
<a href="https://doi.org/10.1016/j.jshs.2020.07.006">https://doi.org/10.1016/j.jshs.2020.07.006</a>
<a href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</a>
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DiFrancisco-Donoghue, J., Werner, W. G., Douris, P. C., & Zwibel, H.
Date
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2020
Publisher
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Elsevier BV
Subject
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Body composition
Body mass index
Gaming
Language
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English
Abstract
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<p><strong class="sub-title">Background:<span> </span></strong>Esports players, like traditional athletes, practice for long hours and, thus, are vulnerable to the negative health effects of prolonged sitting. There is a lack of research on the physical activity and the health ramifications of prolonged sitting by competitive players. The purpose of this study was to investigate activity levels, body mass index (BMI), and body composition in collegiate esports players as compared to age-matched controls.</p>
<p><strong class="sub-title">Methods:<span> </span></strong>Twenty-four male collegiate esports players and non-esports players between 18 and 25 years of age signed a written consent to participate. Physical activity was examined using daily activity (step count) with a wrist-worn activity tracker. A questionnaire assessing physical activity was also administered. Secondary outcomes included body-fat percentage, lean-body mass, BMI, and bone mineral content measured using dual X-ray absorptiometry.</p>
<p><strong class="sub-title">Results:<span> </span></strong>The step count in the esports players was significantly lower than the age-matched controls (6040.2 ± 3028.6 vs. 12843.8 ± 5661.1; p = 0.004). Esports players exhibited greater body-fat percentage (p = 0.05), less lean body mass (p = 0.003), and less bone mineral content (p = 0.03), despite no difference in BMI between the esports and non-esports players.</p>
<p><strong class="sub-title">Conclusion:<span> </span></strong>As compared to non-esports players, collegiate esports players were significantly less active and had a higher body-fat percentage, with lower lean body mass and bone mineral content. The BMIs showed no difference between the 2 groups. Esports athletes displayed significantly less activity and poor body composition, which are all correlated with potential health issues and risk of injury. BMI did not capture this difference and should not be considered as an accurate measure of health in competitive esports players.</p>
Source
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<em>Journal of Sport and Health Science </em>Volume 11, Issue 6, November 2022, pages 725-730
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<span>This article is available under the </span><a target="_blank" href="https://creativecommons.org/licenses/" rel="noreferrer noopener">Creative Commons CC-BY-NC-ND</a><span> license and permits non-commercial use of the work as published, without adaptation or alteration provided the work is fully attributed.</span>
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PDF
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Text
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<span>DiFrancisco-Donoghue, J., Werner, W. G., Douris, P. C., & Zwibel, H. (2022). Esports players, got muscle? Competitive video game players’ physical activity, body fat, bone mineral content, and muscle mass in comparison to matched controls. In Journal of Sport and Health Science (Vol. 11, Issue 6, pp. 725–730). Elsevier BV. <a href="https://doi.org/10.1016/j.jshs.2020.07.006">https://doi.org/10.1016/j.jshs.2020.07.006</a></span>
body composition
body mass index
gaming
-
https://repository.nyitlibrary.org/files/original/f7057fd6ee58739b43e0eb1fc5fe61b2.pdf
249c4eecc3d4b31feb66420d572b33ee
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Title
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NYITCOM - Faculty Publications
Publication
Book or Journal Article published by New York Tech Facility.
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Adaptations for Bipedal Walking: Musculoskeletal Structure and Three-Dimensional Joint Mechanics of Humans and Bipedal Chimpanzees (Pan troglodytes)
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<a href="https://repository.nyitlibrary.org/files/original/f7057fd6ee58739b43e0eb1fc5fe61b2.pdf">https://repository.nyitlibrary.org/files/original/f7057fd6ee58739b43e0eb1fc5fe61b2.pdf</a><br /><br /><a href="https://doi.org/10.1016/j.jhevol.2022.103195">https://doi.org/10.1016/j.jhevol.2022.103195</a>
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O’Neill, M. C., Demes, B., Thompson, N. E., Larson, S. G., Stern, J. T., Jr., & Umberger, B. R.
Date
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2022
Publisher
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Elsevier BV
Subject
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Bipedalism
Elastic energy
Force
Locomotion
Power
Work
Language
A language of the resource
English
Abstract
A summary of the resource.
Humans are unique among apes and other primates in the musculoskeletal design of their lower back, pelvis, and lower limbs. Here, we describe the three-dimensional ground reaction forces and lower/hindlimb joint mechanics of human and bipedal chimpanzees walking over a full stride and test whether: 1) the estimated limb joint work and power during the stance phase, especially the single-support period, is lower in humans than bipedal chimpanzees, 2) the limb joint work and power required for limb swing is lower in humans than in bipedal chimpanzees, and 3) the estimated total mechanical power during walking, accounting for the storage of passive elastic strain energy in humans, is lower in humans than in bipedal chimpanzees. Humans and bipedal chimpanzees were compared at matched dimensionless and dimensional velocities. Our results indicate that humans walk with significantly less work and power output in the first double-support period and the single-support period of stance, but markedly exceed chimpanzees in the second double-support period (i.e., push-off). Humans generate less work and power in limb swing, although the species difference in limb swing power was not statistically significant. We estimated that total mechanical positive 'muscle fiber' work and power were 46.9% and 35.8% lower, respectively, in humans than in bipedal chimpanzees at matched dimensionless speeds. This is due in part to mechanisms for the storage and release of elastic energy at the ankle and hip in humans. Furthermore, these results indicate distinct 'heel strike' and 'lateral balance' mechanics in humans and bipedal chimpanzees and suggest a greater dissipation of mechanical energy through soft tissue deformations in humans. Together, our results document important differences between human and bipedal chimpanzee walking mechanics over a full stride, permitting a more comprehensive understanding of the mechanics and energetics of chimpanzee bipedalism and the evolution of hominin walking.
Source
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<em>Journal of Human Evolution </em>Volune 168, July 2022, page 103195
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<span>This article is available under the </span><a target="_blank" href="https://creativecommons.org/licenses/" rel="noreferrer noopener">Creative Commons CC-BY-NC-ND</a><span> license and permits non-commercial use of the work as published, without adaptation or alteration provided the work is fully attributed.</span>
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<span>O’Neill, M. C., Demes, B., Thompson, N. E., Larson, S. G., Stern, J. T., Jr., & Umberger, B. R. (2022). Adaptations for bipedal walking: Musculoskeletal structure and three-dimensional joint mechanics of humans and bipedal chimpanzees (Pan troglodytes). In Journal of Human Evolution (Vol. 168, p. 103195). Elsevier BV. <a href="https://doi.org/10.1016/j.jhevol.2022.103195">https://doi.org/10.1016/j.jhevol.2022.103195</a></span>
bipedalism
elastic energy
force
locomotion
power
work
-
https://repository.nyitlibrary.org/files/original/667c55996f468c6e5304c4e1655510f0.pdf
2730525895d9909e5736cc7c9bb37af9
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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NYITCOM - Faculty Publications
Publication
Book or Journal Article published by New York Tech Facility.
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Caffeine and Dobutamine Challenge Induces Bidirectional Ventricular Tachycardia in Normal Rats
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<a href="https://repository.nyitlibrary.org/files/original/667c55996f468c6e5304c4e1655510f0.pdf">https://repository.nyitlibrary.org/files/original/667c55996f468c6e5304c4e1655510f0.pdf</a>
<a href="https://doi.org/10.1016/j.hroo.2020.08.005">https://doi.org/10.1016/j.hroo.2020.08.005</a>
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Zhang, C., & Zhang, Y.
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
Subject
The topic of the resource
Bidirectional ventricular tachycardia
Caffeine
Dantrolene
Dobutamine
Ventricular arrhythmia
Language
A language of the resource
English
Rights
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<h3>Copyright</h3>
<div class="copyright">© 2020 Heart Rhythm Society. Published by Elsevier Inc.</div>
<h3>User license</h3>
<a href="http://creativecommons.org/licenses/by-nc-nd/4.0/" class="userLicLnk">Creative Commons Attribution – NonCommercial – NoDerivs (CC BY-NC-ND 4.0)</a><span> </span>|<span> </span>
<div class="dropBlock reference-citations"><a href="https://www.heartrhythmopen.com/article/S2666-5018(20)30114-8/fulltext#" class="reference-citations__ctrl">How you can reuse</a><span> </span></div>
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PDF
Abstract
A summary of the resource.
<div>
<h4 class="u-h4 u-margin-m-top u-margin-xs-bottom">Background</h4>
<p>Bidirectional<span> </span><a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/ventricular-tachycardia" title="Learn more about ventricular tachycardia from ScienceDirect's AI-generated Topic Pages" class="topic-link">ventricular tachycardia</a><span> </span>(BD-VT) is an intriguing arrhythmia, characterized by a beat-to-beat alternation of the QRS polarity on electrocardiogram. Currently there is no simple BD-VT animal model.</p>
</div>
<div>
<h4 class="u-h4 u-margin-m-top u-margin-xs-bottom">Objective</h4>
<p><span>We report a simple animal model of BD-VT induced by caffeine and <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/dobutamine" title="Learn more about dobutamine from ScienceDirect's AI-generated Topic Pages" class="topic-link">dobutamine</a> (C+D) challenge in normal rats in which the arrhythmia can be attenuated by </span><a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/dantrolene" title="Learn more about dantrolene from ScienceDirect's AI-generated Topic Pages" class="topic-link">dantrolene</a><span> (a <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/ryanodine-receptor" title="Learn more about ryanodine receptor from ScienceDirect's AI-generated Topic Pages" class="topic-link">ryanodine receptor</a> stabilizer) <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/therapeutic-procedure" title="Learn more about treatment from ScienceDirect's AI-generated Topic Pages" class="topic-link">treatment</a>, but not by the pacemaker <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/channel-blocker" title="Learn more about channel blocker from ScienceDirect's AI-generated Topic Pages" class="topic-link">channel blocker</a> <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/ivabradine" title="Learn more about ivabradine from ScienceDirect's AI-generated Topic Pages" class="topic-link">ivabradine</a> treatment.</span></p>
</div>
<div>
<h4 class="u-h4 u-margin-m-top u-margin-xs-bottom">Methods</h4>
<p>Adult (4–5 months old) Sprague-Dawley rats (both sexes) were randomized into C+D (n = 8, received caffeine 120 mg/kg intraperitoneally [IP] and dobutamine 60 μg/kg IP, sequentially) and control (n = 8) groups. In addition, a group of 7 rats were pretreated with dantrolene (10 mg/kg, IP) 30 minutes before the C+D challenge and another group of 8 rats were pretreated with ivabradine (5 mg/kg, IP) 30 minutes before the C+D challenge.</p>
</div>
<div>
<h4 class="u-h4 u-margin-m-top u-margin-xs-bottom">Results</h4>
<p><span>C+D challenge induced spontaneous <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/premature-ventricular-contraction" title="Learn more about premature ventricular contractions from ScienceDirect's AI-generated Topic Pages" class="topic-link">premature ventricular contractions</a> (PVCs) in 7 of 8 rats and BD-VT (lasted 4.3 ± 2.9 minutes, terminated spontaneously) in 6 of 8 (75%) rats. No <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/heart-ventricle-arrhythmia" title="Learn more about ventricular arrhythmia from ScienceDirect's AI-generated Topic Pages" class="topic-link">ventricular arrhythmia</a> was induced in the control group (</span><em>P</em><span> </span>< .05 vs C+D group). Dantrolene treatment significantly decreased BD-VT (1 of 7 rats in the Dantrolene+C+D group vs 6 of 8 rats in C+D group,<span> </span><em>P</em><span> </span>< .05). Ivabradine treatment did not affect C+D-induced BD-VT (7 of 8 rats in the Ivabradine+C+D group vs 6 of 8 in the C+D group,<span> </span><em>P</em><span> </span>> .05).</p>
</div>
<div>
<h4 class="u-h4 u-margin-m-top u-margin-xs-bottom">Conclusion</h4>
<p>Caffeine and dobutamine challenge induces BD-VT in a majority of normal rats. Stabilizing<span> </span><a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/ryanodine-receptor-2" title="Learn more about cardiac ryanodine receptors from ScienceDirect's AI-generated Topic Pages" class="topic-link">cardiac ryanodine receptors</a><span> </span>with dantrolene treatment can significantly decrease the occurrence of BD-VT, but pacemaker channel blocker ivabradine treatment does not have effect in this animal model.</p>
</div>
Source
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<em>Heart Rhythm O2</em>, Volume 1, Issue 5, December 2020, pages 359-367
Type
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Text
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<span>Zhang, C., & Zhang, Y. (2020). Caffeine and dobutamine challenge induces bidirectional ventricular tachycardia in normal rats. In Heart Rhythm O2 (Vol. 1, Issue 5, pp. 359–367). Elsevier BV. <a href="https://doi.org/10.1016/j.hroo.2020.08.005">https://doi.org/10.1016/j.hroo.2020.08.005</a></span>
Publisher
An entity responsible for making the resource available
Elsevier BV
Bidirectional ventricular tachycardia
Caffeine
Dantrolene
Dobutamine
Ventricular arrhythmia
-
https://repository.nyitlibrary.org/files/original/09a4bcbf409ddd13afe0348f2f4a2b4c.pdf
12011a6730f217556dc05429fdd12087
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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NYITCOM - Faculty Publications
Publication
Book or Journal Article published by New York Tech Facility.
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Triiodothyronine Maintains Cardiac Transverse-Tubule Structure and Function
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<a href="https://repository.nyitlibrary.org/files/original/09a4bcbf409ddd13afe0348f2f4a2b4c.pdf">https://repository.nyitlibrary.org/files/original/09a4bcbf409ddd13afe0348f2f4a2b4c.pdf</a>
<a href="https://doi.org/10.1016/j.yjmcc.2021.06.010">https://doi.org/10.1016/j.yjmcc.2021.06.010</a>
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PDF
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Gilani, N., Wang, K., Muncan, A., Peter, J., An, S., Bhatti, S., Pandya, K., Zhang, Y., Tang, Y.-D., Gerdes, A. M., Stout, R. F., & Ojamaa, K.
Date
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2021
Language
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English
Abstract
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Subclinical hypothyroidism and low T3 syndrome are commonly associated with an increased risk of cardiovascular disease (CVD) and mortality. We examined effects of T3 on T-tubule (TT) structures, Ca 2+ mobilization and contractility, and clustering of dyadic proteins.
Thyroid hormone (TH) deficiency was induced in adult female rats by propyl-thiouracil (PTU; 0.025%) treatment for 8 weeks. Rats were then randomized to continued PTU or triiodo-L-thyronine (T3; 10 μg/kg/d) treatment for 2 weeks (PTU + T3). After in vivo echocardiographic and hemodynamic recordings, cardiomyocytes (CM) were isolated to record Ca 2+ transients and contractility. TT organization was assessed by confocal microscopy, and STORM images were captured to measure ryanodine receptor (RyR2) cluster number and size, and L-type Ca 2+ channel (LTCC, Ca v 1.2) co-localization. Expressed genes including two integral TT proteins, junctophilin-2 (Jph-2) and bridging integrator-1 (BIN1), were analyzed in left ventricular (LV) tissues and cultured CM using qPCR and RNA sequencing.
The T3 dosage used normalized serum T3, and reversed adverse effects of TH deficiency on in vivo measures of cardiac function. Recordings of isolated CM indicated that T3 increased rates of Ca 2+ release and re-uptake, resulting in increased velocities of sarcomere shortening and re-lengthening. TT periodicity was significantly decreased, with reduced transverse tubules but increased longitudinal tubules in TH-deficient CMs and LV tissue, and these structures were normalized by T3 treatment. Analysis of STORM data of PTU myocytes showed decreased RyR2 cluster numbers and RyR localizations within each cluster without significant changes in Ca v 1.2 localizations within RyR clusters. T3 treatment normalized RyR2 cluster size and number. qPCR and RNAseq analyses of LV and cultured CM showed that Jph2 expression was T3-responsive, and its increase with treatment may explain improved TT organization and RyR-LTCC coupling.
Subject
The topic of the resource
Animals
Ca(2+)
Calcium Channels, L-Type metabolism
Calcium Signaling drug effects
Calcium metabolism
Cells, Cultured
Disease Models, Animal
Female
Gene Expression
Heart Ventricles drug effects metabolism
Hypothyroidism blood chemically induced drug therapy
Index Medicus
Junctophilin-2
Membrane Proteins genetics metabolism
Myocytes, Cardiac metabolism
Rats
Ryanodine Receptor Calcium Release Channel metabolism
Ryanodine receptors
STORM
SY7Q814VUP
Sarcolemma metabolism
Sarcomeres metabolism
Thyroid hormone
Transverse-tubules
Treatment Outcome
Triiodothyronine administration & dosage blood
Ventricular Function drug effects
Source
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<em>Journal of Molecular and Cellular Cardiology</em>, Volume 160, November 2021, pages 1-14
Publisher
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Elsevier BV
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Copyright © 2021 The Authors
Type
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Text
Bibliographic Citation
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<span>Gilani, N., Wang, K., Muncan, A., Peter, J., An, S., Bhatti, S., Pandya, K., Zhang, Y., Tang, Y.-D., Gerdes, A. M., Stout, R. F., & Ojamaa, K. (2021). Triiodothyronine maintains cardiac transverse-tubule structure and function. In Journal of Molecular and Cellular Cardiology (Vol. 160, pp. 1–14). Elsevier BV. <a href="https://doi.org/10.1016/j.yjmcc.2021.06.010">https://doi.org/10.1016/j.yjmcc.2021.06.010</a></span>
-
https://repository.nyitlibrary.org/files/original/6cf271c0c7cc2bfcfe261ec3fbe66313.pdf
428d47b8c9183247e73f11b8858ea1fc
Dublin Core
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Title
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NYITCOM - Faculty Publications
Publication
Book or Journal Article published by New York Tech Facility.
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Are endocasts good proxies for brain size and shape in archosaurs throughout ontogeny?
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An unambiguous reference to the resource within a given context
<a href="https://repository.nyitlibrary.org/files/original/6cf271c0c7cc2bfcfe261ec3fbe66313.pdf">https://repository.nyitlibrary.org/files/original/6cf271c0c7cc2bfcfe261ec3fbe66313.pdf</a>
<a href="https://doi.org/10.1111/joa.12918">https://doi.org/10.1111/joa.12918</a>
Creator
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Watanabe, A., Gignac, P. M., Balanoff, A. M., Green, T. L., Kley, N. J., & Norell, M. A.
Publisher
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Wiley
Subject
The topic of the resource
Alligator
Gallus
Diffusible iodine-based contrast-enhanced computed tomography
Geometric morphometrics
Micro-computed tomography
Neuroanatomy
Language
A language of the resource
English
Abstract
A summary of the resource.
Cranial endocasts, or the internal molds of the braincase, are a crucial correlate for investigating the neuroanatomy of extinct vertebrates and tracking brain evolution through deep time. Nevertheless, the validity of such studies pivots on the reliability of endocasts as a proxy for brain morphology. Here, we employ micro-computed tomography imaging, including diffusible iodine-based contrast-enhanced CT, and a three-dimensional geometric morphometric framework to examine both size and shape differences between brains and endocasts of two exemplar archosaur taxa – the American alligator (Alligator mississippiensis) and the domestic chicken (Gallus gallus). With ontogenetic sampling, we quantitatively evaluate how endocasts differ from brains and whether this deviation changes during development. We find strong size and shape correlations between brains and endocasts, divergent ontogenetic trends in the brain-to-endocast correspondence between alligators and chickens, and a comparable magnitude between brain–endocast shape differences and intraspecific neuroanatomical variation. The results have important implications for paleoneurological studies in archosaurs. Notably, we demonstrate that the pattern of endocranial shape variation closely reflects brain shape variation. Therefore, analyses of endocranial morphology are unlikely to generate spurious conclusions about large-scale trends in brain size and shape. To mitigate any artifacts, however, paleoneurological studies should consider the lower brain–endocast correspondence in the hindbrain relative to the forebrain; higher size and shape correspondences in chickens than alligators throughout postnatal ontogeny; artificially ‘pedomorphic’ shape of endocasts relative to their corresponding brains; and potential biases in both size and shape data due to the lack of control for ontogenetic stages in endocranial sampling.
Format
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PDF
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
Source
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<em>Journal of Anatomy</em>, Volume 234, Issue 3, December 2018, pages 291-305
Rights
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Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
Type
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Text
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<span>Watanabe, A., Gignac, P. M., Balanoff, A. M., Green, T. L., Kley, N. J., & Norell, M. A. (2018). Are endocasts good proxies for brain size and shape in archosaurs throughout ontogeny? In Journal of Anatomy (Vol. 234, Issue 3, pp. 291–305). Wiley. <a href="https://doi.org/10.1111/joa.12918">https://doi.org/10.1111/joa.12918</a></span>
Alligator
Alligators and Crocodiles
anatomy and histology
animal
animal experiment
animal model
Animals
article
artifact
Biological Evolution
brain size
chicken
Computer-Assisted
contrast enhancement
controlled study
crocodilian
diffusible iodine-based contrast-enhanced computed tomography
evolution
forebrain
Gallus
geometric morphometrics
Image Processing
micro-computed tomography
morphology
morphometry
neuroanatomy
nonhuman
ontogeny
procedures
quantitative analysis
rhombencephalon
sampling
skull
Tomography
writing
X-Ray Computed
x-ray computed tomography
X-Ray Microtomography
-
https://repository.nyitlibrary.org/files/original/1b7fdd8807458f5f84407113bf7f73ff.pdf
d844e5593cafe534aac42d9264e8b400
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
NYITCOM - Faculty Publications
Publication
Book or Journal Article published by New York Tech Facility.
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Thresholding Segmentation Errors and Uncertainty with Patient-Specific Geometries
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<a href="https://repository.nyitlibrary.org/files/original/1b7fdd8807458f5f84407113bf7f73ff.pdf">https://repository.nyitlibrary.org/files/original/1b7fdd8807458f5f84407113bf7f73ff.pdf</a>
<a href="https://doi.org/10.31661%2Fjbpe.v0i0.2001-1062">https://doi.org/10.31661%2Fjbpe.v0i0.2001-1062</a>
<a href="https://doaj.org/article/4b222bc346244da8bc0d3a4e795f4471">https://doaj.org/article/4b222bc346244da8bc0d3a4e795f4471</a>
Creator
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Toma, M., Lu, Y., Zhou, H., & Garcia, J.D.
Date
A point or period of time associated with an event in the lifecycle of the resource
2021
Subject
The topic of the resource
Medical physics
Medical radiology
Nuclear medicine
Image processing, computer-assisted, errors
Patient-specific modeling
Thresholding
Uncertainty
Language
A language of the resource
English
Abstract
A summary of the resource.
Computer simulations provide virtual hands-on experience when actual hands-on experience is not possible. To use these simulations in medical science, they need to be able to predict the behavior of actual processes with actual patient-specific geometries. Many uncertainties enter in the process of developing these simulations, starting with creating the geometry. The actual patient-specific geometry is often complex and hard to process. Usually, simplifications to the geometry are introduced in exchange for faster results. However, when simplified, these simulations can no longer be considered patient-specific as they do not represent the actual patient they come from. The ultimate goal is to keep the geometries truly patient-specific without any simplification. However, even without simplifications, the patient-specific geometries are based on medical imaging modalities and consequent use of numerical algorithms to create and process the 3D surface. Multiple users are asked to process medical images of a complex geometry. Their resulting geometries are used to assess how the user’s choices determine the resulting dimensions of the 3D model. It is shown that the resulting geometry heavily depends on user’s choices.
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<em>Journal of Biomedical Physics and Engineering</em>, Volume 11, Issue 1, February 2021, pages 115-122
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PDF
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Salvia Medical Sciences Ltd.
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Copyright: © Journal of Biomedical Physics and Engineering.
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Text
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<span>Toma, M. (2021). Thresholding Segmentation Errors and Uncertainty with Patient-Specific Geometries. In Journal of Biomedical Physics and Engineering (Vol. 11, Issue 1). Salvia Medical Sciences Ltd. <a href="https://doi.org/10.31661/jbpe.v0i0.2001-1062">https://doi.org/10.31661/jbpe.v0i0.2001-1062</a></span>
Computer-Assisted
Errors
Image Processing
Patient-Specific Modeling
Thresholding
Uncertainty
-
https://repository.nyitlibrary.org/files/original/b6dba06505452c0b27144634e6c9c02b.pdf
e42d9eee30301c38cd88a93b1b29225f
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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NYITCOM - Faculty Publications
Publication
Book or Journal Article published by New York Tech Facility.
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
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Pulsatile Flow Investigation in Development of Thoracic Aortic Aneurysm: An In-Vitro Validated Fluid Structure Interaction Analysis
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<a href="https://repository.nyitlibrary.org/files/original/1b7fdd8807458f5f84407113bf7f73ff.pdf">https://repository.nyitlibrary.org/files/original/1b7fdd8807458f5f84407113bf7f73ff.pdf</a>
<a href="https://doi.org/10.29252/jafm.12.06.29769">https://doi.org/10.29252/jafm.12.06.29769</a>
Creator
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Ong, C. W., Kabinejadian, F., Xiong, F., Wong, Y. R., Toma, M., Nguyen, Y. N., Chua, K. J., Cui, F. S., Ho, P., & Leo, H.
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
Subject
The topic of the resource
Mechanical engineering and machinery
Thoracic aortic aneurysm
Particle image velocimetry
Thrombus
Fluid structure interaction (FSI)
Hemodynamics
Language
A language of the resource
English
Abstract
A summary of the resource.
Thoracic aortic aneurysm (TAA) is a severe cardiovascular disease with a high mortality rate, if left untreated. Clinical observations show that aneurysm growth can be linked to undesirable hemodynamic conditions of the aortic aneurysm. In order to gain more insight on TAA formation, we developed a computational framework in vitro to investigate and compare the flow patterns between pre-aneurismal and post-aneurismal aorta using a deformable wall model. This numerical framework was validated by an in vitro experiment accounting for the patient-specific geometrical features and the physiological conditions. The complex flow behaviors in the pre-aneurismal and post-aneurismal aorta were evaluated experimentally by particle image velocimetry (PIV). Our experimental results demonstrated flow behaviors similar to those observed in the fluid-structure interaction (FSI) numerical study. We observed a small vortex induced by the non-planarity of pre-aneurismal aorta near the aortic arch in pre-aneurysmal aorta may explain the aneurysm formation at the aortic arch. We found that high endothelial cell action potential (ECAP) correlates with the recirculation regions, which might indicate possible thrombus development. The promising image-based fluid-structure interaction model, accompanied with an in vitro experimental study, has the potential to be used for performing virtual implantation of newly developed stent graft for treatment of TAA.
Source
A related resource from which the described resource is derived
<em>Journal of Applied Fluid Mechanics</em>, Volume 12, Issue 6, January 2019, pages 1855–1872
Rights
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<span>This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.</span>
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PDF
Type
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Text
Bibliographic Citation
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<span>Ong, C. W., Kabinejadian, F., Xiong, F., Wong, Y. R., Toma, M., Nguyen, Y. N., Chua, K. J., Cui, F. S., Ho, P., & Leo, H. (2019). Pulsatile Flow Investigation in Development of Thoracic Aortic Aneurysm: An In-Vitro Validated Fluid Structure Interaction Analysis. In Journal of Applied Fluid Mechanics (Vol. 12, Issue 6, pp. 1855–1872). Academic World Research. <a href="https://doi.org/10.29252/jafm.12.06.29769">https://doi.org/10.29252/jafm.12.06.29769</a></span>
Publisher
An entity responsible for making the resource available
Academic World Research
Fluid structure interaction (FSI)
Hemodynamics
Particle image velocimetry
Thoracic aortic aneurysm
Thrombus
-
https://repository.nyitlibrary.org/files/original/b29c848cdee5d8414366c1fb5b907a0f.pdf
aa5312bb540f3ace0b327eab3f3f14d0
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
NYITCOM - Faculty Publications
Publication
Book or Journal Article published by New York Tech Facility.
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Long genes linked to autism spectrum disorders harbor broad enhancer-like chromatin domains
Identifier
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<a href="https://repository.nyitlibrary.org/files/original/1b7fdd8807458f5f84407113bf7f73ff.pdf">https://repository.nyitlibrary.org/files/original/1b7fdd8807458f5f84407113bf7f73ff.pdf</a>
<a href="https://doi.org/10.1101/gr.233775.117">https://doi.org/10.1101/gr.233775.117</a>
Creator
An entity primarily responsible for making the resource
Zhao, Y.-T., Kwon, D. Y., Johnson, B. S., Fasolino, M., Lamonica, J. M., Kim, Y. J., Zhao, B. S., He, C., Vahedi, G., Kim, T. H., & Zhou, Z.
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
Subject
The topic of the resource
Animals
Autism Spectrum Disorder genetics
Autistic Disorder genetics
Chromatin genetics
Humans
Index Medicus
Male
Mice
Mice, Inbred C57BL
Mutation genetics
Neurogenesis genetics
RNA Polymerase II genetics
Regulatory Sequences, Nucleic Acid genetics
Transcription, Genetic genetics
Language
A language of the resource
English
Abstract
A summary of the resource.
Genetic variants associated with autism spectrum disorders (ASDs) are enriched in genes encoding synaptic proteins and chromatin regulators. Although the role of synaptic proteins in ASDs is widely studied, the mechanism by which chromatin regulators contribute to ASD risk remains poorly understood. Upon profiling and analyzing the transcriptional and epigenomic features of genes expressed in the cortex, we uncovered a unique set of long genes that contain broad enhancer-like chromatin domains (BELDs) spanning across their entire gene bodies. Analyses of these BELD genes show that they are highly transcribed with frequent RNA polymerase II (Pol II) initiation and low Pol II pausing, and they exhibit frequent chromatin–chromatin interactions within their gene bodies. These BELD features are conserved from rodents to humans, are enriched in genes involved in synaptic function, and appear post-natally concomitant with synapse development. Importantly, we find that BELD genes are highly implicated in neurodevelopmental disorders, particularly ASDs, and that their expression is preferentially down-regulated in individuals with idiopathic autism. Finally, we find that the transcription of BELD genes is particularly sensitive to alternations in ASD-associated chromatin regulators. These findings suggest that the epigenomic regulation of BELD genes is important for post-natal cortical development and lend support to a model by which mutations in chromatin regulators causally contribute to ASDs by preferentially impairing BELD gene transcription.
Source
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<em>Genome Research</em>, Volume 28, Issue 7, May 2018, pages 933-942
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PDF
Publisher
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Cold Spring Harbor Laboratory
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© 2018 Zhao et al.; Published by Cold Spring Harbor Laboratory Press
Type
The nature or genre of the resource
Text
Bibliographic Citation
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<span>Zhao, Y.-T., Kwon, D. Y., Johnson, B. S., Fasolino, M., Lamonica, J. M., Kim, Y. J., Zhao, B. S., He, C., Vahedi, G., Kim, T. H., & Zhou, Z. (2018). Long genes linked to autism spectrum disorders harbor broad enhancer-like chromatin domains. In Genome Research (Vol. 28, Issue 7, pp. 933–942). Cold Spring Harbor Laboratory. <a href="https://doi.org/10.1101/gr.233775.117">https://doi.org/10.1101/gr.233775.117</a></span>
animal
animal experiment
animal model
Animals
article
attention deficit disorder
autism
Autism Spectrum Disorder
Autistic Disorder
brain cell
C57BL mouse
chromatin
comparative study
controlled study
DNA isolation
down regulation
enhancer like chromatin domain
enhancer region
epigenetics
gene control
gene frequency
gene identification
Genetic
genetic analysis
genetic association
genetic code
genetic linkage
genetic risk
genetic transcription
genetic variability
genetics
histone modification
human
Humans
immunoprecipitation
Inbred C57BL
intellectual impairment
loss of function mutation
male
Mice
mouse
mutation
nervous system development
Neuro-2a cell line
Neurogenesis
nonhuman
Nucleic Acid
priority journal
promoter region
real time polymerase chain reaction
regulatory sequence
Regulatory Sequences
reverse transcription polymerase chain reaction
risk factor
RNA polymerase II
RNA sequence
small interfering RNA
transcription
transcription initiation
transcription initiation site
-
https://repository.nyitlibrary.org/files/original/c6ed436027cdd74f6ada2d4de3f634a0.pdf
f37339d0afa5a16e18f8dc284627a1c7
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NYITCOM - Faculty Publications
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Book or Journal Article published by New York Tech Facility.
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Fossil Apes and Human Evolution
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<a href="https://repository.nyitlibrary.org/files/original/c6ed436027cdd74f6ada2d4de3f634a0.pdf">https://repository.nyitlibrary.org/files/original/c6ed436027cdd74f6ada2d4de3f634a0.pdf</a>
<a href="https://doi.org/10.1126/science.abb4363">https://doi.org/10.1126/science.abb4363</a>
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Almécija, S., Hammond, A. S., Thompson, N. E., Pugh, K. D., Moyà-Solà, S., & Alba, D. M.
Subject
The topic of the resource
Animals
Biological Evolution
Fossils
Hominidae anatomy & histology classification
Humans
Index Medicus
Phylogeny
Language
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English
Abstract
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Humans diverged from apes (chimpanzees, specifically) toward the end of the Miocene ~9.3 million to 6.5 million years ago. Understanding the origins of the human lineage (hominins) requires reconstructing the morphology, behavior, and environment of the chimpanzee-human last common ancestor. Modern hominoids (that is, humans and apes) share multiple features (for example, an orthograde body plan facilitating upright positional behaviors). However, the fossil record indicates that living hominoids constitute narrow representatives of an ancient radiation of more widely distributed, diverse species, none of which exhibit the entire suite of locomotor adaptations present in the extant relatives. Hence, some modern ape similarities might have evolved in parallel in response to similar selection pressures. Current evidence suggests that hominins originated in Africa from Miocene ape ancestors unlike any living species.
Source
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<em>Science</em>, Volume 372, Issue 6542, May 2021
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2021
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PDF
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American Association for the Advancement of Science (AAAS)
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<div>Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.</div>
<div><a href="https://www.sciencemag.org/about/science-licenses-journal-article-reuse?adobe_mc=MCMID%3D49365048756730316000997922049602443404%7CMCORGID%3D242B6472541199F70A4C98A6%2540AdobeOrg%7CTS%3D1698439059">https://www.sciencemag.org/about/science-licenses-journal-article-reuse</a></div>
<div>This is an article distributed under the terms of the<span> </span><a href="http://www.sciencemag.org/about/science-licenses-journal-article-reuse?adobe_mc=MCMID%3D49365048756730316000997922049602443404%7CMCORGID%3D242B6472541199F70A4C98A6%2540AdobeOrg%7CTS%3D1698439059">Science Journals Default License</a>.</div>
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<span>Almécija, S., Hammond, A. S., Thompson, N. E., Pugh, K. D., Moyà-Solà, S., & Alba, D. M. (2021). Fossil apes and human evolution. In Science (Vol. 372, Issue 6542). American Association for the Advancement of Science (AAAS). <a href="https://doi.org/10.1126/science.abb4363">https://doi.org/10.1126/science.abb4363</a></span>
adaptation
Africa
anatomy and histology
animal
Animals
Biological Evolution
chimpanzee
classification
evolution
fossil
fossil hominoid
fossil record
Fossils
hominid
Hominidae
human
human evolution
Humans
last common ancestor
Miocene
morphology
natural selection
nonhuman
Phylogeny
primate
relative
Review
-
https://repository.nyitlibrary.org/files/original/1acd23bae6fa651e239ba264789c5200.pdf
5a83396f650a782c6e280f1c1798045a
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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NYITCOM - Faculty Publications
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Book or Journal Article published by New York Tech Facility.
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Fluid-Structure Interaction Analyses of Amniotic Fluid with a Comprehensive Fetus Model Exposed to External Loading
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<a href="https://repository.nyitlibrary.org/files/original/1acd23bae6fa651e239ba264789c5200.pdf">https://repository.nyitlibrary.org/files/original/1acd23bae6fa651e239ba264789c5200.pdf</a>
<a href="https://doi.org/10.1016/j.injury.2023.110843">https://doi.org/10.1016/j.injury.2023.110843</a>
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Arias, J., Kurgansky, G., Wei, O. C., Chan-Akeley, R., & Toma, M
Date
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2022
Publisher
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Elsevier BV
Subject
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Fluid-Structure Interaction
Amniotic Fluid
Fetus
Smoothed-Particle Hydrodynamics
Language
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English
Abstract
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<div class="abstract-content selected">
<p><strong class="sub-title">Introduction:<span> </span></strong>Pregnancy-related trauma is one of the leading causes of morbidity and mortality in pregnant women and fetuses. The fetal response to injury is largely dependent on the timing of fetal presentation and the underlying pathophysiology of the trauma. The optimal management of pregnant patients who have suffered an obstetric emergency depends on clinical assessment and understanding of the placental implantation process, which can be difficult to perform during an emergency. Understanding the mechanisms of traumatic injuries to the fetus is crucial for developing next-generation protective devices.</p>
<p><strong class="sub-title">Methods:<span> </span></strong>This study aimed to investigate the effect of amniotic fluid on mine blast on the uterus, fetus, and placenta via computational analysis. Finite element models were developed to analyze the effects of explosion forces on the uterus, fetus, and placenta, based on cadaveric data obtained from the literature. This study uses computational fluid-structure interaction simulations to study the effect of external loading on the fetus submerged in amniotic fluid inside of the uterus.</p>
<p><strong class="sub-title">Results:<span> </span></strong>Computational fluid-structure interaction simulations are used to study the effect of external loading on the fetus/placenta submerged in amniotic fluid inside the uterus. Cushioning function of the amniotic fluid on the fetus and placenta is demonstrated. The mechanism of traumatic injuries to the fetus/placenta is shown.</p>
<p><strong class="sub-title">Discussion:<span> </span></strong>The intention of this research is to understand the cushioning function of the amniotic fluid on the fetus. Further, it is important to make use of this knowledge in order to ensure the safety of pregnant women and their fetuses.</p>
</div>
<p><strong class="sub-title">Keywords:<span> </span></strong>Amniotic fluid; FSI; Fetus; Fluid-structure interaction; Placenta.</p>
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<em>Injury</em>, Volume 54, Issue 8, August 2023, page 110843
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Copyright © 2023 Elsevier Ltd. All rights reserved.
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PDF
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Text
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<span>Arias, J., Kurgansky, G., Wei, O. C., Chan-Akeley, R., & Toma, M. (2023). Fluid-structure interaction analysis of amniotic fluid with fetus and placenta inside uterus exposed to military blasts. In Injury (Vol. 54, Issue 8, p. 110843). Elsevier BV. <a href="https://doi.org/10.1016/j.injury.2023.110843">https://doi.org/10.1016/j.injury.2023.110843</a></span>
Amniotic Fluid
Fetus
fluid-structure interaction
smoothed-particle hydrodynamics
-
https://repository.nyitlibrary.org/files/original/247fa735fc0f1dbe794c4196fae1a8d1.pdf
45a6d410531e066067aba0bcb34ee7c5
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
NYITCOM - Faculty Publications
Publication
Book or Journal Article published by New York Tech Facility.
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Title
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Cannabidiol (CBD) as a Promising Anti-Cancer Drug
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<a href="https://repository.nyitlibrary.org/files/original/247fa735fc0f1dbe794c4196fae1a8d1.pdf">https://repository.nyitlibrary.org/files/original/247fa735fc0f1dbe794c4196fae1a8d1.pdf</a>
<a href="https://doi.org/10.3390/cancers12113203">https://doi.org/10.3390/cancers12113203</a>
Creator
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Seltzer, E. S., Watters, A. K., MacKenzie, D., Jr., Granat, L. M., & Zhang, D.
Date
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2020
Subject
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CBD
Cannabidiol
Cannbinoids
Anti-cancer drug
Language
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English
Abstract
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Recently, cannabinoids, such as cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC), have been the subject of intensive research and heavy scrutiny. Cannabinoids encompass a wide array of organic molecules, including those that are physiologically produced in humans, synthesized in laboratories, and extracted primarily from the Cannabis sativa plant. These organic molecules share similarities in their chemical structures as well as in their protein binding profiles. However, pronounced differences do exist in their mechanisms of action and clinical applications, which will be briefly compared and contrasted in this review. The mechanism of action of CBD and its potential applications in cancer therapy will be the major focus of this review article.
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<em>Cancers</em>, Volume 12, Issue 11, October 2020, page 3203
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PDF
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<span>© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (</span><a href="http://creativecommons.org/licenses/by/4.0/" target="_blank" rel="noreferrer noopener">http://creativecommons.org/licenses/by/4.0/</a><span>).</span>
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Text
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<span>Seltzer, E. S., Watters, A. K., MacKenzie, D., Jr., Granat, L. M., & Zhang, D. (2020). Cannabidiol (CBD) as a Promising Anti-Cancer Drug. In Cancers (Vol. 12, Issue 11, p. 3203). MDPI AG. <a href="https://doi.org/10.3390/cancers12113203">https://doi.org/10.3390/cancers12113203</a></span>
Publisher
An entity responsible for making the resource available
MDPI AG
anti-cancer drug
cannabidiol
cannabinoids; cannabidiol; CBD; anti-cancer drucannabinoids
CBD
-
https://repository.nyitlibrary.org/files/original/5f4d0a05b468fb97ccfa623ce3e3a322.pdf
508f2f7d92c7faa6920bacc605436e5a
Dublin Core
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Title
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NYITCOM - Faculty Publications
Publication
Book or Journal Article published by New York Tech Facility.
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Title
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Addressing Discrepancies between Experimental and Computational Procedures
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<a href="https://repository.nyitlibrary.org/files/original/5f4d0a05b468fb97ccfa623ce3e3a322.pdf">https://repository.nyitlibrary.org/files/original/5f4d0a05b468fb97ccfa623ce3e3a322.pdf</a>
<a href="https://doi.org/10.3390/biology10060536">https://doi.org/10.3390/biology10060536</a>
Creator
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Toma, M., Guru, S. K., Wu, W., Ali, M., & Ong, C. W.
Date
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2021
Subject
The topic of the resource
Chordae Tendineae
Chordal Structure
Comprehensive Computational Model
Fluid-Structure Interaction
Heart Valve
Smooth Particle Hydrodynamics
Language
A language of the resource
English
Abstract
A summary of the resource.
Imaging subject-specific heart valve, a crucial step to its design, has experimental variables that if unaccounted for, may lead to erroneous computational analysis and geometric errors of the resulting model. Preparation methods are developed to mitigate some sources of the geometric error. However, the resulting 3D geometry often does not retain the original dimensions before excision. Inverse fluid–structure interaction analysis is used to analyze the resulting geometry and to assess the valve’s closure. Based on the resulting closure, it is determined if the geometry used can yield realistic results. If full closure is not reached, the geometry is adjusted adequately until closure is observed.
Source
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<em>Biology</em>, Volume 10, Issue 6, June 2021, page 536
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<span>© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (</span><a href="https://creativecommons.org/licenses/by/4.0/" target="_blank" rel="noreferrer noopener">https://creativecommons.org/licenses/by/4.0/</a><span>).</span>
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PDF
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Text
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<span>Toma, M., Guru, S. K., Wu, W., Ali, M., & Ong, C. W. (2021). Addressing Discrepancies between Experimental and Computational Procedures. In Biology (Vol. 10, Issue 6, p. 536). MDPI AG. <a href="https://doi.org/10.3390/biology10060536">https://doi.org/10.3390/biology10060536</a></span>
Publisher
An entity responsible for making the resource available
MDPI AG
chordae tendineae
chordal structure
comprehensive computational model
fixation
fluid–structure interaction
heart valve
inverse finite element
smooth particle hydrodynamics
-
https://repository.nyitlibrary.org/files/original/9fe4b328d3fbbaf0d0c53708bb221980.pdf
4e9b54a564916fe332bb603213a26218
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
NYITCOM - Faculty Publications
Publication
Book or Journal Article published by New York Tech Facility.
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Fluid–Structure Interaction Analyses of Biological Systems Using Smoothed-Particle Hydrodynamics
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<a href="https://repository.nyitlibrary.org/files/original/9fe4b328d3fbbaf0d0c53708bb221980.pdf">https://repository.nyitlibrary.org/files/original/9fe4b328d3fbbaf0d0c53708bb221980.pdf</a>
<a href="https://doi.org/10.3390/biology10030185">https://doi.org/10.3390/biology10030185</a>
Creator
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Toma, M., Chan-Akeley, R., Arias, J., Kurgansky, G. D., & Mao, W.
Date
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2021
Subject
The topic of the resource
Biological Systems
Fluid–Structure Interaction
Numerical Analyses
Simulation
Smoothed-Particle Hydrodynamics
Language
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English
Abstract
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Due to the inherent complexity of biological applications that more often than not include fluids and structures interacting together, the development of computational fluid–structure interaction models is necessary to achieve a quantitative understanding of their structure and function in both health and disease. The functions of biological structures usually include their interactions with the surrounding fluids. Hence, we contend that the use of fluid–structure interaction models in computational studies of biological systems is practical, if not necessary. The ultimate goal is to develop computational models to predict human biological processes. These models are meant to guide us through the multitude of possible diseases affecting our organs and lead to more effective methods for disease diagnosis, risk stratification, and therapy. This review paper summarizes computational models that use smoothed-particle hydrodynamics to simulate the fluid–structure interactions in complex biological systems.
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<em>Biology</em>, Volume 10, Issue 3, March 2021, page 185
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PDF
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MDPI AG
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<div class="fm-copyright half_rhythm"><a href="https://www.ncbi.nlm.nih.gov/pmc/about/copyright/">Copyright</a><span> </span>© 2021 by the authors.</div>
<div class="license half_rhythm">Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (<a href="https://creativecommons.org/licenses/by/4.0/" target="_blank" rel="noreferrer noopener">http://creativecommons.org/licenses/by/4.0/</a>).</div>
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Text
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<span>Toma, M., Chan-Akeley, R., Arias, J., Kurgansky, G. D., & Mao, W. (2021). Fluid–Structure Interaction Analyses of Biological Systems Using Smoothed-Particle Hydrodynamics. In Biology (Vol. 10, Issue 3, p. 185). MDPI AG. <a href="https://doi.org/10.3390/biology10030185">https://doi.org/10.3390/biology10030185</a></span>
biological systems
fluid–structure interaction
numerical analyses
simulation
smoothed-particle hydrodynamics
-
https://repository.nyitlibrary.org/files/original/a78119b80c74d27c18d21fd494fdfe2e.pdf
4084abe6721ff90e0325bf36c4c0cfb9
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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NYITCOM - Faculty Publications
Publication
Book or Journal Article published by New York Tech Facility.
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
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Effect of Edge-to-Edge Mitral Valve Repair on Chordal Strain: Fluid-Structure Interaction Simulations
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<a href="https://repository.nyitlibrary.org/files/original/a78119b80c74d27c18d21fd494fdfe2e.pdf">https://repository.nyitlibrary.org/files/original/a78119b80c74d27c18d21fd494fdfe2e.pdf</a>
<a href="https://doi.org/10.3390/biology9070173">https://doi.org/10.3390/biology9070173</a>
Creator
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Toma, M., Einstein, D. R., Kohli, K., Caroll, S. L., Bloodworth, C. H., IV, Cochran, R. P., Kunzelman, K. S., & Yoganathan, A. P.
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
Abstract
A summary of the resource.
Edge-to-edge repair for mitral valve regurgitation is being increasingly performed in high-surgical risk patients using minimally invasive mitral clipping devices. Known procedural complications include chordal rupture and mitral leaflet perforation. Hence, it is important to quantitatively evaluate the effect of edge-to-edge repair on chordal integrity. in this study, we employ a computational mitral valve model to simulate functional mitral regurgitation (FMR) by creating papillary muscle displacement. Edge-to-edge repair is then modeled by simulated coaptation of the mid portion of the mitral leaflets. in the setting of simulated FMR, edge-to-edge repair was shown to sustain low regurgitant orifice area, until a two fold increase in the inter-papillary muscle distance as compared to the normal mitral valve. Strain in the chordae was evaluated near the papillary muscles and the leaflets. Following edge-to-edge repair, strain near the papillary muscles did not significantly change relative to the unrepaired valve, while strain near the leaflets increased significantly relative to the unrepaired valve. These data demonstrate the potential for computational simulations to aid in the pre-procedural evaluation of possible complications such as chordal rupture and leaflet perforation following percutaneous edge-to-edge repair.
Source
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<em>Biology</em>, Volume 9, Issue 7, July 2020, page 173
Format
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PDF
Subject
The topic of the resource
Chordae tendineae
Chordal strain
Comprehensive model
Computer simulation
Edge-to-edge repair
Fluid-structure interaction
Mitral valve
Publisher
An entity responsible for making the resource available
MDPI AG
Language
A language of the resource
English
Rights
Information about rights held in and over the resource
<span>© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (</span><a href="http://creativecommons.org/licenses/by/4.0/" target="_blank" rel="noreferrer noopener">http://creativecommons.org/licenses/by/4.0/</a><span>).</span>
Type
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Text
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<span>Toma, M., Einstein, D. R., Kohli, K., Caroll, S. L., Bloodworth, C. H., IV, Cochran, R. P., Kunzelman, K. S., & Yoganathan, A. P. (2020). Effect of Edge-to-Edge Mitral Valve Repair on Chordal Strain: Fluid-Structure Interaction Simulations. In Biology (Vol. 9, Issue 7, p. 173). MDPI AG. <a href="https://doi.org/10.3390/biology9070173">https://doi.org/10.3390/biology9070173</a></span>
Biomarker
MicroRNA
Mild traumatic brain injury
Saliva
Sports-related concussion
-
https://repository.nyitlibrary.org/files/original/e9b15442736432b2304a1d23eaac5f32.pdf
e7573e7b0b812416d1a2aee80ae6ef02
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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NYITCOM - Faculty Publications
Publication
Book or Journal Article published by New York Tech Facility.
Dublin Core
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Title
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Attenuated evolution of mammals through the Cenozoic
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<a href="https://repository.nyitlibrary.org/files/original/e9b15442736432b2304a1d23eaac5f32.pdf">https://repository.nyitlibrary.org/files/original/e9b15442736432b2304a1d23eaac5f32.pdf</a>
<br /><a href="https://doi.org/10.1126/science.abm7525">https://doi.org/10.1126/science.abm7525</a>
Creator
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Goswami, A., Noirault, E., Coombs, E. J., Clavel, J., Fabre, A.-C., Halliday, T. J. D., Churchill, M., Curtis, A., Watanabe, A., Simmons, N. B., Beatty, B. L., Geisler, J. H., Fox, D. L., & Felice, R. N.
Date
A point or period of time associated with an event in the lifecycle of the resource
2022
Subject
The topic of the resource
Animals
Biological Evolution
Eutheria anatomy & histology
Female
Fossils
Index Medicus
Phylogeny
Rodentia
Skull anatomy & histology
Language
A language of the resource
English
Abstract
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The Cenozoic diversification of placental mammals is the archetypal adaptive radiation. Yet, discrepancies between molecular divergence estimates and the fossil record fuel ongoing debate around the timing, tempo, and drivers of this radiation. Analysis of a three-dimensional skull dataset for living and extinct placental mammals demonstrates that evolutionary rates peak early and attenuate quickly. This long-term decline in tempo is punctuated by bursts of innovation that decreased in amplitude over the past 66 million years. Social, precocial, aquatic, and herbivorous species evolve fastest, especially whales, elephants, sirenians, and extinct ungulates. Slow rates in rodents and bats indicate dissociation of taxonomic and morphological diversification. Frustratingly, highly similar ancestral shape estimates for placental mammal superorders suggest that their earliest representatives may continue to elude unequivocal identification.
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<em>Science</em>, Volume 378, Issue 6618, October 2022, pages 377-383
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PDF
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American Association for the Advancement of Science (AAAS)
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<span>Copyright © 2022 the authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original US government works. </span><a href="https://www.science.org/content/page/science-licenses-journal-article-reuse?adobe_mc=MCMID%3D20966568074372452772299603847900596611%7CMCORGID%3D242B6472541199F70A4C98A6%2540AdobeOrg%7CTS%3D1700174153">https://www.science.org/about/science-licenses-journal-article-reuse</a>
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Text
Bibliographic Citation
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<span>Goswami, A., Noirault, E., Coombs, E. J., Clavel, J., Fabre, A.-C., Halliday, T. J. D., Churchill, M., Curtis, A., Watanabe, A., Simmons, N. B., Beatty, B. L., Geisler, J. H., Fox, D. L., & Felice, R. N. (2022). Attenuated evolution of mammals through the Cenozoic. In Science (Vol. 378, Issue 6618, pp. 377–383). American Association for the Advancement of Science (AAAS). <a href="https://doi.org/10.1126/science.abm7525">https://doi.org/10.1126/science.abm7525</a></span>
adaptive radiation
anatomy and histology
animal
animal experiment
Animals
article
Biological Evolution
Cenozoic
Cetacea
dissociation
divergence
elephant
Eutheria
evolution
evolutionary rate
female
fossil
fossil record
Fossils
herbivore
innovation
mammal
Mammals
nonhuman
Phylogeny
placenta
placental mammal
precocial species
pregnancy
rodent
Rodentia
skull
ungulate
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https://repository.nyitlibrary.org/files/original/e7c1d7fa21cd93963587bdf5cd3aa8b3.pdf
4f3d0dde9318021ae04aacb84c8f1e28
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NYITCOM - Faculty Publications
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Book or Journal Article published by New York Tech Facility.
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DNA polymerase delta interacting protein 3 facilitates the activation and maintenance of DNA damage checkpoint in response to replication stress
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<a href="https://repository.nyitlibrary.org/files/original/e9b15442736432b2304a1d23eaac5f32.pdf">https://repository.nyitlibrary.org/files/original/e9b15442736432b2304a1d23eaac5f32.pdf</a>
<a href="https://doi.org/10.1002/ame2.12274">https://doi.org/10.1002/ame2.12274</a>
Abstract
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<h4 class="article-section__sub-title section1">Background</h4>
<p>Replication stress response is crucial for the maintenance of a stable genome. POLDIP3 (DNA polymerase delta interacting protein 3) was initially identified as one of the DNA polymerase δ (Pol δ) interacting proteins almost 20 years ago. Using a variety of in vitro biochemical assays, we previously established that POLDIP3 is a key regulator of the enzymatic activity of Pol δ. However, the in vivo function of POLDIP3 in DNA replication and DNA damage response has been elusive.</p>
<h4 class="article-section__sub-title section1">Methods</h4>
<p>We first generated POLDIP3 knockout (KO) cells using the CRISPR/Cas9 technology. We then investigated its biological functions in vivo using a variety of biochemical and cell biology assays.</p>
<h4 class="article-section__sub-title section1">Results</h4>
<p>We showed that although the POLDIP3-KO cells manifest no pronounced defect in global DNA synthesis under nonstress conditions, they are sensitive to a variety of replication fork blockers. Intriguingly, we found that POLDIP3 plays a crucial role in the activation and maintenance of the DNA damage checkpoint in response to exogenous as well as endogenous replication stress.</p>
<h4 class="article-section__sub-title section1">Conclusion</h4>
<p>Our results indicate that when the DNA replication fork is blocked, POLDIP3 can be recruited to the stalled replication fork and functions to bridge the early DNA damage checkpoint response and the later replication fork repair/restart.</p>
Creator
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Zhang, S., Lee, E. Y. C., Lee, M. Y. W. T., & Zhang, D.
Date
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2022
Subject
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DNA Damage
DNA Polymerase III metabolism
DNA Replication
DNA damage checkpoint
DNA polymerase delta
Index Medicus
POLDIP3
Replication stress
Language
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English
Source
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<em>Animal Models and Experimental Medicine</em>, Volume 5, Issue 5, September 2022, pages 461-469
Publisher
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Wiley
Rights
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<p class="copyright">© 2022 The Authors.<span> </span><i>Animal Models and Experimental Medicine</i><span> </span>published by John Wiley & Sons Australia, Ltd on behalf of The Chinese Association for Laboratory Animal Sciences.</p>
<p>This is an open access article under the terms of the<span> </span><a target="_blank" title="Link to external resource" href="http://creativecommons.org/licenses/by-nc-nd/4.0/" rel="noreferrer noopener">Creative Commons Attribution-NonCommercial-NoDerivs</a><span> </span>License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.</p>
Bibliographic Citation
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<span>Zhang, S., Lee, E. Y. C., Lee, M. Y. W. T., & Zhang, D. (2022). <scp>DNA</scp> polymerase delta interacting protein 3 facilitates the activation and maintenance of <scp>DNA</scp> damage checkpoint in response to replication stress. In Animal Models and Experimental Medicine (Vol. 5, Issue 5, pp. 461–469). Wiley. <a href="https://doi.org/10.1002/ame2.12274">https://doi.org/10.1002/ame2.12274</a></span>
DNA damage checkpoint
DNA polymerase delta
POLDIP3
replication stress