Sleep and Circadian Rhythms in Parkinson’s Disease and Preclinical Models

Hunt, J., Coulson, E. J., Rajnarayanan, R., Oster, H., Videnovic, A., & Rawashdeh, O.

Sleep and Circadian Rhythms in Parkinson’s Disease and Preclinical Models

2022

BioMed Central

Animals
Circadian Rhythm
Index Medicus
Mice
Non-motor symptoms
Parkinson Disease diagnosis
Parkinson’s disease
RBD
REM Sleep Behavior Disorder diagnosis
Sleep
circadian
insomnia
rapid eye movement
research models
sleep
sleep behavior disorder

English

The use of animals as models of human physiology is, and has been for many years, an indispensable tool for understanding the mechanisms of human disease. In Parkinson’s disease, various mouse models form the cornerstone of these investigations. Early models were developed to reflect the traditional histological features and motor symptoms of Parkinson’s disease. However, it is important that models accurately encompass important facets of the disease to allow for comprehensive mechanistic understanding and translational significance. Circadian rhythm and sleep issues are tightly correlated to Parkinson’s disease, and often arise prior to the presentation of typical motor deficits. It is essential that models used to understand Parkinson’s disease reflect these dysfunctions in circadian rhythms and sleep, both to facilitate investigations into mechanistic interplay between sleep and disease, and to assist in the development of circadian rhythm-facing therapeutic treatments. This review describes the extent to which various genetically- and neurotoxically-induced murine models of Parkinson’s reflect the sleep and circadian abnormalities of Parkinson’s disease observed in the clinic.

Neurodegeneration, vol. 17, no. 1, Jan. 2022, pp. 1–21

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