POLDIP3: At the Crossroad of RNA and DNA Metabolism

Author(s)

Singh, M., Zhang, S., Perez, A. M., Lee, E. Y. C., Lee, M. Y. W. T., & Zhang, D.

Title

POLDIP3: At the Crossroad of RNA and DNA Metabolism

Date

2022

Publisher

MDPI AG

Subject

DNA damage response
DNA replication
mRNA export
POLDIP3
Pre-mRNA splicing
R-loops
Transcription
Translation

Language

English

Abstract

POLDIP3 was initially identified as a DNA polymerase delta (Pol δ) interacting protein almost twenty years ago. Intriguingly, it also interacts with proteins involved in a variety of RNA related biological processes, such as transcription, pre-mRNA splicing, mRNA export, and translation. Studies in recent years revealed that POLDIP3 also plays critical roles in disassembling genome wide R-loop formation and activating the DNA damage checkpoint in vivo. Here, we review the functions of POLDIP3 in various RNA and DNA related cellular processes. We then propose a unified model to illustrate how POLDIP3 plays such a versatile role at the crossroad of the RNA and DNA metabolism.

Source

Genes, Volume 13, Issue 11, October 2022, page 1921

Rights

© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

Format

PDF

Type

Text

Bibliographic Citation

Singh, M., Zhang, S., Perez, A. M., Lee, E. Y. C., Lee, M. Y. W. T., & Zhang, D. (2022). POLDIP3: At the Crossroad of RNA and DNA Metabolism. In Genes (Vol. 13, Issue 11, p. 1921). MDPI AG. https://doi.org/10.3390/genes13111921

Files

genes-13-01921-v3.pdf

Citation

Singh, M., Zhang, S., Perez, A. M., Lee, E. Y. C., Lee, M. Y. W. T., & Zhang, D., POLDIP3: At the Crossroad of RNA and DNA Metabolism. Genes, Volume 13, Issue 11, October 2022, page 1921, New York Tech Institutional Repository, accessed September 15, 2024, https://repository.nyitlibrary.org/items/show/3721

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